Mega dosing test (2+ grams a week)

[Sven]

Re: Mega dosing test (2+ grams a week)

The excess testosterone that does not bind to the AR converting to estrogen.

isnt this possible with other compounds, such as tren for example?

[Sven]

Re: Mega dosing test (2+ grams a week)

I am just wondering... If this is the only place some of you have heard of androgen receptors, how did you think AAS was used by the body. I am not trying to be a smart ass. I really am curious though.

This isnt the first time these guys have heard of AR's, I think they are trying to better understand how they work, and find proof of this saturation theory. I too want to know these things.

[HungarianBeast]

Re: Mega dosing test (2+ grams a week)

Androgen-
From Wikipedia, the free encyclopedia.
Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates. This includes the activity of the accessory male sex organs and development of male secondary sex characteristics. Androgens, which were first discovered in 1936, are also called androgenic hormones or testoids. Androgens are also the original anabolic steroids. The primary, and most well-known, androgen is testosterone. All natural androgens are steroid derivatives of androstane (19-carbon tetracyclic hydrocarbon nucleus, C19H32). They are also the precursor of all estrogens, the female sex hormones.

A subset of androgens, adrenal androgens, includes any of the 19-carbon steroids synthesized by the adrenal cortex, an adrenal gland, that function as weak steroids or steroid precursors, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione.

Besides testosterone, other androgens include:

Dehydroepiandrosterone (DHEA): a steroid hormone produced from cholesterol in the adrenal cortex, which is the primary precursor of natural estrogens. DHEA is also called dehydroisoandrosterone or dehydroandrosterone.
Androstenedione (Andro): an androgenic steroid, which is produced by the testes, adrenal cortex, and ovaries. While androstenediones are converted metabolically to testosterone and other androgens, they are also the parent structure of estrone. Its use as an athletic or body building supplement has been banned by the International Olympic Committee.
Androstanediol: the steroid metabolite that is thought to act as the main regulator of gonadotropin secretion.
Androsterone: a chemical by-product created during the breakdown of androgens, or derived from progesterone, that also exerts minor masculinising effects, but with one-seventh the intensity of testosterone. It is found in approximately equal amounts in the plasma and urine of both males and females.
Androstenolone: an androgenic steroid secreted by the adrenal cortex and testes, which is a major precursor of testosterone, but is even weaker than androsterone.
Dihydrotestosterone (DHT): a metabolite of testosterone that is actually a more potent androgen in that it binds more strongly to androgen receptors.
Reduced ability of a XY karyotype fetus to respond to androgens can result in one of several problems, including infertility and several forms of intersex conditions. See androgen insensitivity syndrome (AIS).

See also: andrology, antiandrogen

[Sven]

Re: Mega dosing test (2+ grams a week)

Every chemical that runs through your body is taken up by a "receptor" and then delivered to it's appropriate place. Every chemical's given receptor has a very specific shape that will ONLY allow that specific chemical in. Unfortunately, or sometimes fortunately, there are chemicals that may almost identically resemble another in composition and "clog" a receptor keeping out the good stuff you want and uptaking the crap you don't. Another scenario are (synapsis problems) overactive or underactive receptors that may let too much or too little of a chemical in. Of course this is overly simplified and there are different processes involved that can make it even more complicated and change the way a person "responds" to gear. But how you "respond" to ANY drug, AAS or not, is a biochemical process with specific mathematical properties.

thank you GP.

[HungarianBeast]

Re: Mega dosing test (2+ grams a week)

Hormone receptor-
From Wikipedia, the free encyclopedia.
A hormone receptor is a receptor protein on the surface of a cell or in its interior that binds to a specific hormone. The hormone causes many changes to take place in the cell.

Hormone receptors are often transmembrane proteins.

Binding of hormones to hormone receptors often trigger the start of signal transduction pathways, or trigger the activation of inhibition of genes.

[HungarianBeast]

Re: Mega dosing test (2+ grams a week)

there are many receptors in the body:

GABA receptor
Histamine receptor
Metabotropic receptor
Dopamine receptor
Tonic receptor
Adenosine receptor
Color receptors
Olfactory receptor
Acetylcholine receptor
Hormone receptor
Sensory receptor
Phasic receptor

[HungarianBeast]

Re: Mega dosing test (2+ grams a week)

So if you mega dose on test or ANY other drug there are consequences involved regarding the unused portion of your dose. Something has to be done with it and since your test receptors are "full" then the androgens then have to sit around and wait their turn. Well, while they are waiting their turn they are being circulated through your blood stream, damaging your organs, shutting down your testes. AND since your estrogen receptors are not full that patiently waiting androgen has plenty of time to convert into estrogen to be used by the estrogen receptors which is obviously not good lol

There is also some conversion of testosterone to DHT. DHT has bad side effects that include augmentation of male pattern baldnes and increased chances of prostate cancer. DHT is the prime "fuel" for prostate cancer in it's beginning stages.

[Equalizer]

Re: Mega dosing test (2+ grams a week)

the women in that article claims steroids increase testosterone production
then a sentence later says it can shut down production, which as we all know is correct.....just thought that was odd.

[HungarianBeast]

Re: Mega dosing test (2+ grams a week)

It's kind of like megadosing protein. Sure you can eat 800g a day, but your body will not use it all. Unfortunately with hormones, there are undesireable side effects associated with it.

[Equalizer]

Re: Mega dosing test (2+ grams a week)

the women in that article claims steroids increase testosterone production
then a sentence later says it can shut down production, which as we all know is correct.....just thought that was odd. Oh and GP is that u in your avatar?

[Skarhead]

Re: Mega dosing test (2+ grams a week)

HB, u tend to minintrepet things. obviously we heard of receptors. what im trying to get is the "saturation" theory . where ur receptors become less receptive ... since ive never read any scientific artiel on it

[HungarianBeast]

Re: Mega dosing test (2+ grams a week)

the women in that article claims steroids increase testosterone production
then a sentence later says it can shut down production, which as we all know is correct.....just thought that was odd.

ummm...that IS strange... and wrong.

[Sven]

Re: Mega dosing test (2+ grams a week)

So are you saying if the receptors are full or completely saturated at 500mgs test/week (for example) if after say 12 weeks you bump your dose to 750mgs/week test, the extra 250 is wasted and the AR's cant use it ?

[Equalizer]

Re: Mega dosing test (2+ grams a week)

saturation and less receptive are 2 different things....im interested in if there is actually proof they become less receptive over time IF you give yourself time off, not if say u are on like a 10 month cycle cuzz personal experience would tell me not to do that again for alot of reasons and using higher dosages/more sides is the main one unless i was going to make some kind of a career out of it.

[Sven]

Re: Mega dosing test (2+ grams a week)

HB, u tend to minintrepet things. obviously we heard of receptors. what im trying to get is the "saturation" theory . where ur receptors become less receptive ... since ive never read any scientific artiel on it

yes, I also want to know if a receptor can be damaged if it is "abused" or "flooded" with hormones, be it too much hormones or adequate hormones for extended periods of time.