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Welcome EvoMuse to the Muscle Research store!
At Muscle Research, we want to bring you the best supplements available. We are constantly developing new products, as well as adding those from other top notch companies. Most recently, we have added Evolutionary Muse to the store. I have been using EvoMuse products since they have been released and let me tell you, I am so stoked to see these over here! They’re all great in their own ways, but let me just highlight some things for you:
Abliderate AMMO
Abliderate Advanced is one of the topical fat burners and is a favorite of those who still have a bit more fat to lose (around the 18-20% mark). AMMO is a pill form with a few tweaks. This is a great one to help out with cortisol control, as well and is a solid non-stim addition.
CardioTryx
This is a unique product. You take it about an hour before your cardio activity. I’ve been using this since its release and love it. My cardio isn’t your typical LISS/HIIT/etc.; rather, I use it before pick-up basketball games or flag football games. It does have caffeine in it, but a serving only has 80mg, so it’s very minimal. I rock this an hour out and then slightly before I’ll take my Pump Juice (for the beta alanine, caffeine, betaine, etc.) and a Bronkaid cap (to help with my narrow nasal passage). It’s great.
Defuse
Have I used the word unique much? Defuse is a product that you take about half an hour out from your largest meal of the day. Or you can just rock it before cheat meals if you’re cutting or just keeping your meal sizes small in general. I’ll pop some Defuse, wait about 10-15 minutes and take my GDA/nutrient partitioner of choice (fav. combo is SlinTensity + NaRALA) and then eat at that 30 min mark (and I personally take 500mg Metformin ahead of time, too). This is an excellent one to have on hand to keep fat storage down while eating more or rocking those cheat meals.
Eviscerate Smolder
There are 3 versions of Eviscerate: the OG version, Smolder, and Burn Free Forumla (BFF). Smolder is probably the most popular because there’s still a bit of a burning sensation, but not as strong as the OG (be careful where you apply it!). This is the topical that’s great as you’re already leaner and down to the last bit. It’s also great for localized application (e.g. on your delts for a shoulder lift day).
Gut Health
This is a probiotic that’s been around for a long time. Great option for you. I like to switch between this and Eupepsia from time to time.
MyoSynergy
I don’t know what to say about this one other than WOW. I was among the first to try it and it’s just phenomenal. Stacking this with X Factor (ArA) results in an incredible natty muscle-gaining, fat-burning stack. You will experience some of the worst/most intense DOMS (delayed onset muscle soreness) ever with either of these products, but especially with the combo. I actually joked and called it ROMS because it’s not even delayed; it’s rapid. This an X-Factor are hands down my favorite natty products out there. Great to bridge into PCT with, use during a natty run, or even add alongside your cycle (though I’d take advantage outside of cycling because it’s so awesome).
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At Muscle Research, we want to bring you the best supplements available. We are constantly developing new products, as well as adding those from other top notch companies. Most recently, we have added Evolutionary Muse to the store. I have been using EvoMuse products since they have been released and let me tell you, I am so stoked to see these over here! They’re all great in their own ways, but let me just highlight some things for you:
Abliderate AMMO
Abliderate Advanced is one of the topical fat burners and is a favorite of those who still have a bit more fat to lose (around the 18-20% mark). AMMO is a pill form with a few tweaks. This is a great one to help out with cortisol control, as well and is a solid non-stim addition.
CardioTryx
An Innovative & Cutting-Edge Cardio and Endurance Amplifier: CardioTryx by EvoMuse! We are thrilled to announce the release of CardioTryx, a supplement that is truly the first of its kind. We like to call it a "Cardio Amplifier". If you are into endurance sports, MMA, are prepping for a contest or special life event and you want to maximize your cardiovascular training without spending hours on end, this is your product. CardioTryx has been designed to do three main things: Increase endurance Reduce perception of work and pain Shift the body''s fuel substrate usage from carbohydrate to fat These three things are accomplished by some very novel mechanisms; which are thoroughly explained in this write-up backed by 86 published studies. We plan on this being an immediate must-have supplement for MMA fighters, Crossfitters, and really anyone that wants to squeeze dramatically more out of each minute they spend doing cardio or metabolic training. CardioTryx is so potent, that we recommend you only use it once per day about 45 minutes before cardio or metabolic conditioning (a lot of this has to do with the significant boost to AMPk, explained below). Those of you doing two-a-day workouts might be able to get away with 1.5x the normal dose split up before each session, but this will require self-experimentation, as everyone will respond differently. Each ingredient has been broken down for you, detailing what it is and why it was included in the formula. A ton of research went into this product, and we encourage you to spend some time reading through this so you can truly understand why we are so excited about bringing you this product. As you read this description you will see that we have spent an immense amount of effort perfecting this product. CardioTryx will assist you in reaching your training goals in less time, and with less effort, than ever before. You will lose more fat per minute of cardio, continue burning fat after training is over, reduce the tedium of cardio training, and amplify your body's ability to adapt. You will be able to break through plateaus and reach performance levels you had previously only dream of. CardioTryx – Reach Deep and Achieve! CardioTryx ingredient: Platycodin D Where does it come from? Platycodin D. is isolated from the roots of the Platycodon grandiflorum plant, found in East Asia. Performance or Fat Loss? Fat Loss What are the Primary Effects of this ingredient? AMPk Activation: Fat loss and fat gain are moderated by numerous complex mechanisms, and AMPk is a key player in this flux. Generally speaking, bolstering AMPk activation is great for fat loss, in the right amount. Platycodin d. has been shown in multiple studies to significantly inhibit fat gain and increase fat burning through AMPk activation. Downstream, this AMPk activation attenuates activation of SREBP-1 and fatty acid synthase (FAS), two hormones responsible for fat storage. This is done in a novel way by triggering SIRT1 and CaMMK-b. Crank up AMPk too high for too long, and we run the risk of losing muscle. We want to get a nice warm crackling fire burning in the fireplace without setting the furniture ablaze. This is one of the reasons it is generally advised to stick to once per day dosing of CardioTryx, before exercise to get the maximum benefits without risking muscle loss from chronic AMPk activation. PPAR-y and C/EBPa Modulation Platycon D. has been shown to reduce abdominal and whole body fat accumulation in mice fed an obesogenic diet by targeting two important cellular fat storage proteins, PPAR-y and C/EBPa . Basically they gave mice Platycodon D., tried to make them fat, and couldn''t do it. Adipokine and Glucose Management Another recent study trying to fatten up mice found that Platycodon D. was able to kick-start adiponectin (a fat burning adipokine) locally in fat cells while keeping it stable in serum compared to the placebo group. It was also able to suppress TNFa (an inflammatory cytokine) locally in fat cells. This resulted in reduced food intake and reduced fat accumulation while increasing glucose uptake in skeletal muscle . With regards to glucose, another study showed it was able to reduce blood sugar without stimulating insulin release, which is great for enhancing fat burning as well as long term health. CardioTryx ingredient: Methyl Cinnamate Where does it come from? Methyl Cinnimate (MC) is an ester of cinnamic acid found in several plants and spices. Performance or Fat Loss? Fat Loss What are the Primary Effects? Like Platycodin D., MC interacts favorably with PPAR-y, SREBP-1, and C/EBPa, CaMMK2, and AMPk. However, MC targets pre-adipocytes, preventing potential fat cells from going down that pathway, thereby reducing the ability of the body to accumulate fat storage. CardioTryx ingredient: Rhodiola crenulata/rosea (Standardized for 6% Salidroside content) Where does it come from? Rhodiola is a plant in the Crassulaceae family; various forms of it grow in cold regions all over the world. Performance or Fat Loss? Both What are the Primary Effects? The published beneficial effects of Rhodiola are nothing short of daunting in volume, the focus here will be on just the most exciting, primary reasons for inclusion in this formula. Performance: EPO/Hematopoiesis Stimulation: Erythropoietin, or EPO, is a hormone responsible for stimulating blood cell production (a process known as hematopoiesis). Exogenous EPO has become infamous in recent years as a doping agent used in professional cycling due to its profound benefits on boosting cardiovascular performance. One of the star players in Rhodiola is a compound called Salidroside, which has been shown in multiple studies to boost EPO. Lactate control, ROS scavenging, Muscle damage reduction, Anti-inflammation: A recent study out of Italy looked at the effect of Rhodiola supplementation in trained athletes, and found, among other things, that the supplemented group showed significantly lower levels of blood lactate and creatine kinase (a marker of muscle damage) after exhaustive exercise compared to placebo. Rhodiola also cranks up superoxide dismutase (SOD), which is a crucial antioxidant in almost all cells of the body exposed to oxygen . The reduced damage from ROS allows the body to optimally recover from exercise and reduces muscle damage. Supporting the body''s natural antioxidant system is the only way to go around exercise, as adding in most exogenous antioxidants can overload the already up-regulated system and actually delay recovery . Along these lines, salidroside has also been shown to be cardioprotective against oxidative stress and elevated homocysteine levels, even when subjects were given a potent cardiotoxic antitumor pharmaceutical drug. One of the biggest obstacles to hurdle in hard training athletes is inflammation control. Some inflammation after exercise is necessary for proper adaptation, but those who tend to train hard and often will typically battle with controlling the balance between just enough inflammation, and chronic, performance crushing inflammation. Rhodiola/salidroside has been shown in multiple studies to help reduce excessive inflammation by targeting NF-kB, COX2, TNF-a, and the inflammatory interleukins. Finally on the performance front, Salidroside potentially has another cool effect, it could turn out to be a great tool to help power through those rough cold weather workouts. A very recent study out of China showed Salidroside supplementation reduced mucus overproduction induced by cold stimulation. Fat Loss: Appetite.....Losing fat is tough to do when you get stressed out and fire down an entire bag of Oreos. Salidroside has been shown to modulate a stress response that can trigger binge eating. A recent study out of Italy basically mimicked what physique athletes often do, reduce calories and deprive themselves; then inevitably end up facing temptation. The Salidroside treated group was able to resist "highly palatable foods" and avoid binge eating. Insulin Sensitivity, Fat Oxidation, AMPk Activation, & More: Salidroside has been shown to activate AMPk, thereby enhancing glucose uptake and insulin sensitivity at the muscle cell, as well as the other previously mentioned benefits of turning up AMPk on fat loss. In a 30-day study published in the Journal of Sports Medicine and Physical Fitness, researchers took 14 male athletes, made them do exhaustive cardio, and measured several blood markers with and without Rhodiola supplementation. They found that the same athletes exhibited significantly higher levels of fat oxidation after Rhodiola supplementation. Not only can Rhodiola help you burn more fat during exercise, it has also been shown to reduce fat accumulation when you''re not exercising. CardioTryx ingredient: Acacia Catechu Where does it come from? Found growing in various parts of China and India, Acacia Catechu is a tall thorny tree. It was selected for inclusion in CardioTryx as a source of epicatechin and EGCG. Performance or Fat Loss? Both. What are the Primary Effects? Performance: Triggers building of new blood vessels and mitochondria, improves blood flow. Epicatechin does a bunch of cool things to improve performance. A 2013 study found supplementation for 30 days increased something called vascular endothelial growth factor (VEGF), which is a protein responsible for initiating the building of new blood vessels, particularly after exercise . The same study also demonstrated epicatechin''s ability to improve skeletal muscle capillarity (simply put, improved blood flow due to less friction from the vessel walls). The authors also suggested it may stimulate mitochondrial proliferation, which is a wonderful thing for improving performance. Interestingly enough, the positive benefits were maintained a full 15 days after cessation of the supplement. Other studies have also demonstrated increased angiogenesis (at rest and during exercise, by 30% and 50% respectively) and reduced mean arterial pressure with epicatechin supplementation. Another recent paper published in the Journal of Physiology also demonstrated the same beneficial effect on capillarity and mitochondrial volume. An interesting finding in this study was that epicatechin was able to do this in the absence of exercise, but even more so when combined with exercise, well above what exercise can do on its own . What did that relate to, with regards to exercise performance? Quite a bit. The supplemental group improved treadmill performance by 50%, and reduced fatigue by 30%. The more capillaries you have per muscle fiber equates to more blood flow to the area doing work, faster clearance of metabolic byproducts, and plenty of beneficial downstream effects on performance and body composition. Cardio training (and metabolic training like Crossfit) has a profound effect on increasing the capillary:muscle (C:M) fiber ratio. Researchers at Wayne State University put 32 mice through intense exercise 5 times per week for 5 weeks, and measured the C:M ratio, which increased significantly from baseline. They then gave one group epicatechin, and another group just water. After 14 days, the epicatechin group was able to maintain the heightened C:M ratio. Reduces inflammation, muscle damage, perception of work, and age related performance loss. Researchers know that if you want to induce muscle damage for testing purposes, one of the best ways to do that is with downhill running. Haramizu, et. al., tested this out on mice and found that the supplemented group had significantly lower muscle damage and they actually had an increased level of voluntary wheel running following the testing . This is highly relevant to those that train hard and want to get back at it the next day, I''m assuming these mice weren''t training for any competitions, but they still wanted to go for another run after getting their butts kicked. Another study looking at downhill running found that eight weeks of catechin ingestion "…attenuates the aging-associated loss of force production, oxidative stress, and inflammation in muscle after exercise". Fat Loss: Numerous studies have looked at the fat loss effects of epicatechin and EGCG, and it appears to be effective for this purpose by again attacking the C/EBP and PPAR-y angle, and even suppressing adipocyte differentiation (keeping preadipocytes from becoming fat cells). CardioTryx ingredient: Baicalin Where does it come from? Baicalin is a flavone found in the herb blue skullcap. Fat Loss or Performance? Both, with an emphasis on fat loss What are the Primary Effects? Performance: Only one published paper to date has looked at the beneficial effects of Baicalin on exercise performance parameters. Researchers out of Taiwan aimed to find the root of the hypothalamic signaling melee leading to heatstroke during exercise, and suggested that baicalin might be effective at mitigating this process. Fat Loss: Modulates AKt, CaMKKb, AMPk, ACC, C/EBP, FAS, KLF-2 & KLF-15. What does that alphabet soup mean for fat loss? Lots, actually. If you''ve been following along, several of those acronyms should already make sense. Baicalin is again going to downregulate PPAR-y and C/EBPs, which does so by suppressing Akt phosphorylation through inhibition of PDK1 . The net result of this, among other things, is going to be inhibiting fat accumulation by attenuating preadipocyte differentiation. Baicalin is another AMPk activator, which does so through the favorable CaMMK pathway like Platycodin d. . Researchers in Shanghai conducted a profound study in mice fed a high fat diet (HFD) with or without baicalin supplementation . Keep in mind that mice don''t normally eat a high fat diet, and their metabolic machinery is ill adapted to do so. After 16 weeks, the bicalin group saw the following effects: Suppression of body weight gain normally caused by the HFD Reduced visceral fat Decreased cholesterol Decreased circulating FFA''s (a sign of increased fat oxidation) Decreased circulating insulin Reduced TNF-a (a potent inflammatory cytokine) Reduced liver fat gain Stimulation of AMPk and ACC Decreased SREBP-1c and FAS This is a perfect storm for fat loss, which makes baicalin a potentially potent weapon in the fat loss game. Another study out of Korea supported the previously seen fat loss potential and concluded that baicalin upregulates anti-fat storage regulators (KLF-2) and downregulates pro-fat storing regulators (KLF-15) which results in an inhibition of cellular fat accumulation. CardioTryx ingredient: Antrodia Camphorata Where does it come from? Antrodia camphorata is a mushroom found growing in Taiwan. Performance or Fat Loss? Performance What are the Primary Effects? Little published data is available yet on the use of this compound for physical performance, but we hope to see more in the future as it appears to hold promise. In a recent university study, the researchers found some pretty impressive results. Increased exercise endurance Increased glycogen storage Decreased plasma lactate Decreased plasma ammonia Decreased creatine kinase (muscle breakdown byproduct) Increased grip strength CardioTryx ingredient: Chitooligosaccharide Where does it come from? This is an oligosaccharide (a combination of several saccharides) derived from chitosan, which comes from treating crustacean shells with a special hydroxide. Performance or Fat Loss? Both, with an emphasis on performance What are the Primary Effects? Recent research has shown chitooligosaccharide can induce mitochondrial biogenesis, increase exercise endurance capacity, and act as an "exercise mimetic". It appears to do these things through activation of Sirt1 and AMPk (which also make it a potentially viable fat burning compound), making it a great support nutrient to the other ingredients in CardioTryx targeting that also modulate these areas. CardioTryx ingredient: Galangin Where does it come from? Galangin is a flavonol found in several places including Alpinia officinarum, Alpinia galanga (Zingiberaceae), and Helichrysum aureonitens. Performance or Fat Loss? Both, with some solid general health effects as well. What are the Primary Effects? Performance: First, let''s talk brain function, starting with a brief primer acetylcholine, as this will come up again with regards to other CardioTryx ingredients. Acetylcholine is a neurotransmitter that interacts centrally and peripherally. In the brain it is an excitatory neurotransmitter that can contribute to better exercise performance, quicker speed of thought and better memory when it remains at optimal levels. In cardiac muscle, it can help control heart rate from getting too high during exercise. Endurance exercise has been shown to deplete acetylcholine, which could affect performance. Galangin is one of several ingredients in the formula that posess an inhibitory effect on acetylcholinesterase, the enzyme responsible for breaking down acetylcholine. Fat Loss: Galangin targets fat loss through several distinct angles. In a recent study published in the journal Pharmaceutical Biology, the researchers wanted to find out what six weeks of feeding mice a crappy diet with and without galangin supplementation would do. Here''s The Impressive Results From The Supplemental Group Compared to The Non-Supplemented Group: Fat and weight gain were inhibited Increased calorie intake was inhibited (they voluntarily ate less) Decreased serum lipids Decreased liver weight and liver triglycerides Decreased lipid peroxidation (decreased cellular oxidative damage) In a couple of other recent papers, researchers gave rats a bunch of fructose to induce metabolic damage, with and without galangin. Here''s what Galangin did: Improved insulin sensitivity (fructose feeding initiates insulin resistance) Acted as an anti-inflammatory/hepatoprotective agent in the liver (lowered TNF-a, NF-kB and IL-6) Acted as an antioxidant, reducing oxidative damage from the diet CardioTryx ingredient: Phosphatidylcholine Where does it come from? Choline is found in a variety of food sources, usually in the form of phosphatidylcholine (red meat, egg yolks). Performance or Fat Loss? Performance What are the Primary Effects? As discussed previously, endurance exercise has the potential to deplete choline levels. PC is a precursor to acetylcholine, and multiple studies have shown that supplementation can improve exercise performance. A study published in the Journal of the International Society of Sports Nutrition found that "acute oral supplementation with PC has been demonstrated to improve performance in a variety of sporting activities where exercise has depleted circulatory choline concentrations". Another study out of Germany looked at choline levels in trained athletes during exercise and measured the effect of PC supplementation . The researchers found that exercise alone dropped choline levels by 17%, and the addition of PC prevented choline levels from dropping at all. They also looked at PC supplementation without exercise and found that it raised choline levels by 27%. CardioTryx ingredient: Artemisia Princeps Where does it come from? Artemisia is a plant found growing in China and Japan. Performance or Fat Loss? Mainly fat loss with some potential benefits on performance and general health What are the Primary Effects? Performance: The potential performance enhancing effect of AP once again targets the choline route. A 2012 study published in the Journal of Medicinal Food found that AP acted as an acetylcholinesterase inhibitor, and could act to enhance the cholinergic neurotransmitter system. Fat Loss: Inhibition of fat storage, AMPk activatior, Anti-inflammatory. AP has quite a bit of research highlighting its potential as an anti-obesity agent. In mice fed a high fat diet for 14 weeks, AP was able to reverse all of the measured negative effects, including inhibition of the fat storing enzyme FAS, suppression of elevated leptin, and reducing body weight, glucose and insulin back to previous levels before initiation of the high fat diet. In another study looking at diabetic animals, AP suppressed several enzymes responsible for fat storage including FAS, and it lowered triglyceride and cholesterol synthesis as well as brown adipose tissue (BAT). In vitro, AP has been shown to increase the translocation of skeletal muscle GLUT4 (where insulin docks to drive glucose into the cell) and inhibit AMPk. General Health Benefits: Peroxynitrate scavenger Immunomodulatory Anti-inflammatory Reduces oxidized LDL''s CardioTryx ingredient: Schisandra Chinensis Where does it come from? Schisandra chinensis is a woody vine found in China, Russia and Finland. Performance or Fat Loss? Performance, with some general health bonuses What are the Primary Effects? Performance: Nitric Oxide, anti-inflammation, heat stress protection, immunostimulation. Nitric Oxide (NO) boosting supplements have seen a rise and subsequent (well-deserved) fall in popularity over recent years. One is unlikely to gain any beneficial effects out of most NO boosting supplements with regards to muscle gain, strength, or body composition. They do tend to crank up vascularity though, which makes them addictive to meatheads everywhere. However, for metabolic and/or endurance style training, when coupled with hematopoietic agents (discussed in the Rhodiola section), an increase in NO production, or a reduction in NO breakdown does hold promise for improving performance. Two recent studies have demonstrated the ability of Schisandra to boost NO levels. Schisandra is also the second ingredient with potential to have a protective effect against heat stress during exercise in addition to baicalin. As previously discussed, inflammation control is crucial for recovery in hard training athletes. Multiple studies have demonstrated a beneficial effect from Schisandra on muting inflammatory cytokines like TNF-a, NF-kB, and COX2. General Health Benefits: Support for hepatic triglyceride & cholesterol levels (on par with fenofibrate) Immunostimulation Prevents lipid peroxidation CardioTryx ingredient: Cynomorium Songaricum Where does it come from? Cynomorium songaricum comes from the plant family Cynomoriaceae. Performance or Fat Loss? Performance What are the Primary Effects? This unique ingredient holds quite a bit of promise for performance enhancement, and has demonstrated some interesting anti-aging effects. A recent study out of China found that supplemental CS significantly elevated free radical scavenging enzymes in swimming rats thereby reducing oxidative damage, and was able to reduce muscle fatigue, which improved their endurance by 61% . While often used to improve sexual function and treat kidney dysfunction in traditional Chinese medicine, researchers have also found that CS creates an environment with a heightened resistance to oxidative stress and starvation, lower lipid hydroperoxide levels, suppressed age related learning impairments, and an extension of mean and maximum lifespan in flies. CardioTryx ingredient: Grifola Frondosa Where does it come from? Grifola Frondosa is a mushroom that can be commonly found growing around the base of oak trees, and is considered a "medicinal mushroom" in Japanese and Chinese herbology. Performance or Fat Loss? Both, with an emphasis on fat loss What are the Primary Effects? Performance: Grifola is another ingredient in the CardioTryx formula that should provide NO support, this time by increasing inducible nitric oxide synthase (iNOS) levels . It has also been shown to help control inflammatory cytokines and boost the immune system. Fat Loss: Numerous studies have demonstrated some pretty cool effects on Grifola''s ability to enhance fat loss. At least three separate papers have highlighted its ability to lower fasting blood glucose. Researchers out of Tokyo found it was able to inhibit conversion of pre-adipocytes in white adipose tissue (WAT), as well as reduce triglyceride accumulation and upregulate uncoupling proteins (UCP1) in brown fat (BAT) . Another study out of Tokyo re-affirmed the ability to inhibit adipocyte differentiation as well as reduce the expression of the aforementioned C/EBPs. Finally, a great study published in the Journal of Pharmacy and Pharmacology demonstrated a slew of benefits in diabetic mice: Reduced body weight Reduced insulin Reduced triglycerides and total cholesterol Reduced circulating FFA''s (meaning more fat is being oxidized) Reduced malondialdehyde (MDA) Increased hepatic glycogen Increased activity of SOD Increased insulin sensitivity and amelioration of insulin resistance in peripheral tissues CardioTryx ingredient: Angelica Polysaccharides Where does it come from? Angelica polysaccharides come from the plant Angelica sinensis, also known as dong quai. It has been used in traditional Chinese medicine to combat fatigue and anemia. Performance or Fat Loss? Performance What are the Primary Effects? This is the third ingredient in CardioTryx included for it''s ability to boost hematopoiesis, which it has been shown to do in vitro as well as in vivo in multiple studies. AP has also demonstrated anti-inflammatory effects. CardioTryx ingredient: Guanidinopropionic Acid (GPA) Where does it come from? GPA is a creatine analogue, that has a vastly different effect than creatine itself. It is beneficial for fat loss as it tells the body it has low cellular energy concentrations, and therefore you should avoid taking creatine along with it as they will be working against each other. For a great, in-depth review of how it works in the body, see this article. Performance or Fat Loss? Both, with an emphasis on fat loss What are the Primary Effects? Performance: A review of GPA data shows it has a unique ability to increase tolerance to fatigue, likely because it shifts the body into a fat burning metabolism which provides a much greater pool of energy over glucose burning with less accumulation of fatigue inducing ROS. Fat Loss: GPA is a potent, well-studied fat loss tool that exerts its effect through multiple mechanisms. Two different studies have demonstrated its ability to increase GLUT4 concentration at the muscle cell membrane by 60% which will lead to better insulin sensitivity and glucose management. A PLoS One review in 2013 looked at 131 studies on GPA and found that it demonstrated a significant ability to shift the skeletal muscle metabolism from glycolitic to oxidative (better for burning fat), as well as increasing cellular glucose uptake . GPA also targets fat loss by providing another trigger for AMPk boosting. CardioTryx ingredient: Caffeine Where does it come from? Caffeine is naturally found in a variety of sources including coffee beans, tea leaves and cocoa nuts. Performance or Fat Loss? Both What are the Primary Effects? Caffeine is probably one of the most studied ergogenic aids next to creaine; here''s the key points extrapolated from the volumes of research. Performance: Increased cellular oxygen uptake during exercise Allows ability to perform more exercise with no increased sensation of effort Moderate doses improve performance just as much as high doses Blunts perceived exertion and pain perception, provides a more positive subjective experience while training Shown to be ergogenic in intense exercise ranging from 4-180 seconds, and improves performance in single and multiple sprint intervals Redosing caffeine six hours later not necessary to maintain increased performance in two-a-day workouts Significantly improves time to exhaustion during exercise, even when taken four hours prior to workout Fat Loss: Increased rates of thermogenesis, fat oxidation, and lean mass sparing. CardioTryx ingredient: Aminolevulinic Acid Where does it come from? Aminolevulinic acid is found in the body, produced by the enzyme ALA synthase from glycine and succinyl CoA. It is included in the CardioTryx formula as a heme precursor. Performance or Fat Loss? Both, primarily performance What are the Primary Effects? Performance: As stated Aminolevulinic acid is utilized here as a heme precursor, a major component of hemoglobin. Fat Loss: Aminolevulinic acid has also been shown in a new study published in the Journal Nutrition to modestly drop fasting blood glucose in adult humans who are mildly hyperglycemic. CardioTryx ingredient: Ferric Bis-Glycinate Where does it come from? Ferric bis-glycinate is a highly absorbable form of iron. It has been shown to have a 91% bioavailability compared to the 27% achieved with the common form of iron in multi-vitamins, ferrous sulfate. Performance or Fat Loss? Performance What are the Primary Effects? One of the potential side effects of boosting NO is depletion in iron levels, which can then negatively affect performance . We''ve got your bases covered. Even minor iron depletion that does not register as clinical anemia can negatively affect performance. In one study, subjects with mild iron deficiency exercised for four weeks and their performance decreased throughout, while the 86% of the iron supplemented group showed improved performance times. Recommended Dosage As a dietary supplement, take 6 capsules an hour before your workout with plenty of water. WARNING Consult your physician before using this or any dietary supplement. Do not take if you are pregnant or breast feeding, elderly or under the age of 18, chronically ill, or taking any prescription or over-the-counter medicine, including but not limited to antidepressants (such as MAO inhibitors), stimulants, allege medications, and medications for high blood pressure or other cardiovascular conditions. Discontinue use if you experience dizziness, headache, nausea, or heart palpitations. If you have trouble sleeping, do not take within 6 hours of bedtime. Keep out of reach of children. Before beginning any program of weight loss, consult your healthcare practitioner. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
This is a unique product. You take it about an hour before your cardio activity. I’ve been using this since its release and love it. My cardio isn’t your typical LISS/HIIT/etc.; rather, I use it before pick-up basketball games or flag football games. It does have caffeine in it, but a serving only has 80mg, so it’s very minimal. I rock this an hour out and then slightly before I’ll take my Pump Juice (for the beta alanine, caffeine, betaine, etc.) and a Bronkaid cap (to help with my narrow nasal passage). It’s great.
Defuse
Defuse by EvoMuse: An Innovative & Cutting-Edge Fat Gain Inhibitor! We can't always be completely strict on diet. Sometimes Holidays come up...sometimes we are looking to increase muscle gain. Either way, the goal is to maintain physique and prevent fat gain. NEW Defuse by EvoMuse was designed for just that purpose. There are multiple biological pathways that calories can travel through to cause fat storage. The more you are able to block those pathways, the more your body will change preference to burn that fat off as energy rather than store it. Using a comprehensive and dynamic formula, Defuse helps to prevent fat gain normally caused by short periods of extra calories. Thermodynamics and Biochemistry.... A couple of mouthfuls that don't have the potential to make you fat. Calories, on the other hand, do. The feeding of Calories into the system known as the Human Body, and where those Calories finally end up, is a highly complex process. A number of sensing and processing pathways are put into play, each dealing with different nutrients (fat, carbs, etc), that either direct nutrients to be used as fuel, or stored as fat. The fat storage pathways are numerous but, lucky for us, can be manipulated, or inhibited, leaving potential jiggly ugliness circulating in the body to be burned for metabolic fuel. We can't always remain perfectly strict on our diets (and let's be honest who wants to?) so for those times (muscle gaining cycles, holidays, vacations) we need a new approach to keeping lean. With Defuse, we have done just that. The Defuse formula helps to prevent fat gain by preventing the mechanisms for fat storage from working optimally, leaving the body with no choice but to burn that fat away. Defuse fat gain inhibitor pre-glossary The science behind Defuse is thick, but very digestible if you understand some key physiological terms. Give this pre-glossary a quick read, then as you go through the write up and come across one of these terms you may want to revisit the definition to get a better grasp. Or if you're already a super science nerd, feel free to skip over this section and get right to the meat. Pre-Adipocytes & Pre-Adipocyte Differentiation Pre-adipocytes are immature fat cells that have not yet developed distinguishing characteristics. Basically like the Army Reserve, they're called upon when needed, but instead of going into battle they are transformed into full-fledged fat cells through a process called differentiation. At this point they can start storing lipid droplets containing fats, cholesterol, and various metabolic machinery. Peroxisome Proliferator-Activated Receptor Gamma (PPARy) Of the three known PPAR subtypes (alpha, delta, gamma), PPARy is the only one that encourages nutrient storage upon activation. It is intricately involved in the uptake of carbohydrate and fat into adipose tissue, as well as being a key signal to trigger adipocyte differentiation. CCAAT-Enhancer Bbinding Proteins (C/EBP's) C/EBP's include a family of six transcription factors, for our purposes we are just concerned with C/EBPa and C/EBPb. Both of these are directly involved in pre-adipocyte differentiation and work in conjunction with PPARy. AMP-Activated Protein Kinase (AMPk) AMPk is a major regulator of cellular energy signaling. Upregulation triggers skeletal muscle fatty acid oxidation (fat burning), increased insulin sensitivity, and glucose uptake. Normally, AMPk is triggered during conditions of low cellular energy (low glycogen storage, energy depletion during exercise, calorie restriction, etc). During times of caloric excess (which is exactly when you'll be using Defuse), AMPk is significantly downregulated, which is quite detrimental for fat loss; hence the inclusion of AMPk activators in the formula. Transient Receptor Potential Vanilloid Receptor 1 (TrpV1) A few years ago some groundbreaking research came out implicating this receptor as a major player in obesity. This is the receptor that capsaicin from chili peppers interacts with, and quite a bit of research has demonstrated that triggering TrpV1 has a significant effect on fat burning. Hormone Sensitive Lipase (HSL) HSL is crucial for the initial phase of fat loss. It is imperative for breaking down the stored triglyceride in a fat cell into free fatty acids (FFA's) so they can be transported for oxidation (burning). The breakdown of stored triglyceride into FFA's (before transport and oxidation of the fat even occur) is a three-step process, and HSL governs the first step, and is also the rate-limiting step. Boosting HSL allows the other two steps to do more work, which allows for more fat to be burned. Fatty Acid Synthase (FAS) Think of FAS as the anti-HSL, basically performing the opposite function, encouraging the storage of fat. It is comprised of a group of enzymes regulated upstream by SREBP-1c, which is triggered by insulin. Research shows a significant upregulation of FAS in obesity, coupled with suppressed HSL. Brown Adipose Tissue (BAT) BAT is structurally and functionally different from white adipose tissue (WAT). BAT contains several, small lipid droplets surrounding the large nuclear machinery in the middle, whereas WAT contains one huge lipid droplet with a small nucleus near the cell wall. That right there gives some indication of the function of the BAT cell, along with its high mitochondria density and UCP1 expression. BAT's main function is generating heat by burning calories; the numerous small lipid droplets release their fat in response to cold in order to elevate body temperature. People with higher BAT levels (or better BAT signaling) take longer to start shivering in the cold, as their bodies are able to maintain better homeostatic thermoregulation. Defuse ingredient: Acacia Catechins Where does it come from? Found growing in various parts of China and India, Acacia Catechu is a tall thorny tree. It was selected for inclusion in Defuse as a source of epicatechin and EGCG. What are the Primary Effects? PPARy and C/EBP: Acacia Catechins have been shown to suppress pre-adipocyte differentiation through the blockade of two important fat storage proteins, C/EBP and PPARy, which has a downstream inhibition on the master fat storing gatekeeper. Defuse ingredient: Platycodon saponins Where does it come from? Platycodin d. is isolated from the roots of the Platycodon grandiflorum plant, found in East Asia. What are the Primary Effects? AMPk Activation: Fat loss and fat gain are moderated by numerous complex mechanisms, and AMPk is a key player in this flux. Generally speaking, bolstering AMPk activation is great for fat loss, in the right amount. Platycodin d. has been shown in multiple studies to significantly inhibit fat gain and increase fat burning through AMPk activation. Downstream, this AMPk activation attenuates activation of SREBP-1 and fatty acid synthase (FAS), two hormones responsible for fat storage. This is done in a novel way by triggering SIRT1 and CaMMK-b. PPAR-y and C/EBPa Modulation Platycon d. has been shown to reduce abdominal and whole body fat accumulation in mice fed an obesogenic diet by PPAR-y and C/EBPa Error: Reference source not found. Basically they gave mice Platycodon d., tried to make them fat, and couldn't do it. Adipokine and Glucose Management Another recent study trying to fatten up mice found that Platycodon d. was able to kick-start adiponectin (a fat burning adipokine) locally in fat cells while keeping it stable in serum compared to the placebo group. It was also able to suppress TNFa (an inflammatory cytokine) locally in fat cells. This resulted in reduced food intake and reduced fat accumulation while increasing glucose uptake in skeletal muscle. With regards to glucose, another study showed it was able to reduce blood sugar without stimulating insulin release, which is great for enhancing fat burning as well as long term health. Defuse ingredient: Baicalin Where does it come from? Baicalin is a flavone found in the herb blue skullcap. What are the Primary Effects? AKt, CaMKKb, AMPk, ACC, PPARy, C/EBP, FAS, KLF-2 & KLF-15: Baicalin has been shown to downregulate PPAR-y and C/EBPs; it does this by suppressing Akt phosphorylation through inhibition of PDK1. The net result of this, among other things, is going to be inhibiting fat accumulation by attenuating preadipocyte differentiation. Baicalin is another AMPk activator, which does so through the favorable CaMMK pathway like Platycodin d. Error: Reference source not found. Researchers in Shanghai conducted a profound study in mice fed a high fat diet (HFD) with or without baicalin supplementation. Keep in mind that mice don't normally eat a high fat diet, and their metabolic machinery is ill adapted to do so. After 16 weeks, the bicalin group saw the following effects: Suppression of body weight gain normally caused by the HFD Reduced visceral fat Decreased cholesterol Decreased circulating FFA's (a sign of increased fat oxidation) Decreased circulating insulin Reduced TNF-a (a potent inflammatory cytokine) Reduced liver fat gain Stimulation of AMPk and ACC Decreased SREBP-1c and FAS Another study out of Korea supported the previously seen fat loss potential and concluded that baicalin upregulates anti-fat storage regulators (KLF-2) and downregulates pro-fat storing regulators (KLF-15) which results in an inhibition of cellular fat accumulation.This is a perfect storm for prevention of fat gain. Defuse ingredient: Methyl Cinnamate Where does it come from? Methyl Cinnimate (MC) is an ester of cinnamic acid found in several plants and spices. What are the Primary Effects? MC again targets pre-adipocytes through modulation of PPAR-y, SREBP-1, and C/EBPa, CaMMK2, and AMPk, thereby reducing the ability of the body to accumulate fat storage. Defuse ingredient: Salvia miltiorrhiza Where does it come from? Salvia miltiorrhiza is an Asian perennial plant from the Salvia genus. What are the Primary Effects? DGAT, Glucose Sensitivity, Hepatic Lipid Metabolism: Diglyceride acetyltransferase (DGAT) is the enzyme responsible for the third and final step in producing a triglyceride from glycerol and fatty acids. Inhibit DGAT, which Salvia m. has been shown to do, and you reduce fat accumulation and increase leptin sensitivity significantly. If your body wants to store more fat; it cranks up DGAT activity. Salvia m. has also been shown in research to improve uptake of glucose in skeletal muscle, thereby reducing fat storage through a 2nd angle. When feeding two groups of rats a fattening diet for six weeks, the control group showed increased body fat accumulation, hyperinsulinemia, hyperlipidemia, and increased liver enzymes. The group fed the same diet in conjunction with Salvia m. did not show any of these negative effects from the high fat diet. Defuse ingredient: Raspberry Ketone Where does it come from? Raspberry Ketone (RK) is a natural phenolic, aromatic compound found in raspberries, cranberries and blackberries. What are the Primary Effects? TRPV1, NE, HSL: Activating the Transient Receptor Potential Vanilloid Type 1 protein (TRPV1) offers numerous benefits for fat loss and general health, including prevention of adipogenesis and obesity. Through modulation of norepinephrine (NE) and hormone sensitive lipase (HSL), RK appears to be a powerhouse for encouraging fat loss and prevention of fat gain. When mice were fed fattening diet, RK prevented visceral and liver fat accumulation as well as reversing the fat gain in previously obese mice. Recently liver fat has been implicated in metabolic disturbances to an even greater degree than the previous villain, visceral fat, so this is a benefit of great magnitude for overall health. Defuse ingredient: 18b-glycyrrhetinic acid Where does it come from? 18b-glycyrrhetinic acid (18b-GA) is a metabolite of glycyrrhetinic acid with very unique properties found in the licorice herb. What are the Primary Effects? While high doses of licorice/glycyrrhetinic acid have been shown to inhibit the enzyme 11b-HSD, which is responsible for converting cortisol to the inactive form cortisone, the low dose of this specific 18b metabolite have some important yet unrelated effects. PPARy, C/EBPa, HSL, HbA1c, Inflammation 18b-GA is another ingredient in DeFuse selected for its potent inhibitory effect on the likely now familiar PPARy and C/EBPa pathway. A recent university study out of South Korea found that 18b-GA was able to decrease lipid accumulation by downregulation of PPARy and C/EBPa in maturing pre-adipocytes. In addition to this effect on pre-adipocytes, it was also able to increase fat release, upregulate HSL, adipose TG lipase and perilipin in mature fat cells. So basically 18b-GA is going to prevent immature fat cells from becoming fat cells, and increase lipolysis in mature fat cells, a perfect two pronged attack. Another study out of India showed that 18b-GA was able to control blood glucose and HbA1c in diabetic rats on par with the potent pharmaceutical glibenclamide. It also appears to have a significant effect on preventing free fatty acid induced lipid accumulation and lipotoxicity by stabilizing mitochondrial lysosomes and improving liver function. Finally, 18b-GA has also been shown to be anti-inflammatory by reducing IL-8. Current research shows that inflammation is likely a major contributing factor to fat gain, so by reducing inflammatory interleukins we can help create a more optimal hormonal environment. Defuse ingredient: 6-gingerol Where does it come from? Gingerol, found in ginger, is chemically similar to capsaicin and piperine. Once cooked, gingerol becomes zingerone. What are the Primary Effects? PPARy, C/EBPa, FAS, SREBP-1c, Acetyl-CoA, Akt, AP2/4, ROS, Inflammation: In a university study out of Tokyo, researchers looked at the effect of gingerol on rats fed a fattening diet to see if it could alleviate any of the damage. They found it was able to reduce plasma insulin, SREBP-1c, and liver acetyl-CoA carboxylase, which attenuated both body weight gain and fat accumulation. 6-gingerol is also an effective player in our main theme of targeting pre-adipocyte differentiation. Both in vitro and in vivo, we see anti-adipogenic properties through reduction in PPARy, C/EBPa and FAS. The researchers performing these studies also found that it was able to reduce levels of something called adipocyte-specific fatty acid binding protein (aP2, also called FABP4), which is a carrier protein for fatty acids and has become an emerging target protein for treating diabetes and obesity. In addition to the direct anti-adipogenic effects, gingerol can also control oxidative damage by reducing intracellular ROS and boosting glutathione, as well as reduce inflammation by blocking TNF-a, NF-kB and PKC signaling. Defuse ingredient: Cinchonine Where does it come from? Cinchonine is a natural compound found in Cinchona bark, indigenous to the Western Andes. What are the Primary Effects? During overfeeding, cinchonine supplemented subjects gained 40% less weight, 25% less visceral fat, and had lower levels of triglycerides, glucose, serum cholesterol and free fatty acids. It also inhibited the diet induced upregulation of inflammatory cytokines by inhibiting Toll Like Receptor 2 (TLR2). In summary, it was shown to reduce fat gain and inflammation compared to control groups when given a fattening diet. Defuse ingredient: (-)Hydroxycitric acid Where does it come from? Hydroxycitric Acid (HCA) is found in the tropical plant Garcinia cambogia. What are the Primary Effects? HCA has been shown to favorably alter the expression of genes that regulate adipogenesis and lipolysis, which makes it a great addition to the Defuse formula. New research shows that it appears to do so by blocking a key enzyme called atp-citratelyase. In a previous study, HCA was also shown to reduce fatty acid synthesis from glucose. Defuse ingredient: Anthocyanins/betalains Where does it come from? Anthocyanins and betalains are a class of pigmentations found in various plants, fruits and flowers, with numerous health-promoting effects. What are the Primary Effects? PPARy, Adiponectin, NPY, Glucose, Leptin, Resistin: Once again, we're targeting inhibition of PPARy to suppress fat storage. Anthocyanins have been shown to do just this, causing suppressed pre-adipocyte differentiation and lipid accumulation. A brand new university study out of Korea looked at rats on a normal diet vs. rats on a normal diet plus anthyocyanins for 40 days. Here's what they found in the supplemented group: Significantly lower body weight Reduced fat cell size Reduced expression of neuropeptide Y (a neurotransmitter that signals increased food intake and fat storage) and of protein kinase A (a regulator of cellular energy storage). Another study looked at the effects of anthocyanin supplementation over 10 weeks and found that it lowered total cholesterol, triglycerides, serum leptin and resistin. The researchers concluded that anthocyanins "…posess a preventative potential for obesity-associated diseases". Other studies have shown an anti-obesity effect as well, demonstrating resistance to fat gain with supplementation. Betalains specificaly have been shown to boost adiponectin, act as an antioxidant, and prevent LDL oxidation. Defuse ingredient: Loranthus Where does it come from? Loranthus is a parasitic plant found growing on branches of woody trees, from the Loranthaceae family. What are the Primary Effects? FAS inhibition, glucose: Loranthus has several studies supporting its ability to potently inhibit FAS, making it a perfect choice to prevent fat gain, and a key ingredient in the formula. Initially, Tian et. al, discovered that loranthus potently inhibits FAS to a greater extent than cerulenin and C75 (currently used to inhibit FAS in a laboratory setting), and also reduced body weight in tested subjects. Next, they established an IC50 value (a measurement used to determine the inhibitory potency of a compound) and found that loranthus has both a fast acting and long acting effect on FAS inhibition. Finally, they determined that the FAS inhibitory activity of loranthus comes from a specific family (Loranthaceae), so it is important to use this form, which we have done in Defuse. At least two other studies have shown the ability of loranthus to favorably regulate blood glucose levels, in diabetic and non-diabetic subjects. Defuse ingredient: Citrus aurantium Where does it come from? Citrus aurantium (CA) refers to a citrus tree and its fruit, which contains N-methyltyramine, octopamine and synephrine. What are the Primary Effects? PPARy, C/EBP (a&b), FAS, aP2: Quite a bit of research has been done on CA, for now we just want to focus on a couple of studies that make it highly relevant for its inclusion in the Defuse formula. The first noteworthy study looked at CA's effect on pre-adipocyte differentiation, and it turned out to do pretty much everything we want in an anti-fat gain compound. It was shown to downregulate PPARy, C/EBPb and C/EBPa (expression of C/EBPa makes fat cells more sensitive to insulin). In addition to this, it also dramatically decreased FAS and aP2, as well as other fat signaling pathways. This demonstrates CA's ability to positively manipulate the fat storage vs. fat burning pathway and inhibit adipocyte differentiation. Finally, a recent meta-analysis looking at a combination of 20 published and unpublished studies including 360 human subjects concluded that supplemental CA increases resting metabolic rate and energy expenditure. Defuse ingredient: Lotus leaf Where does it come from? Lotus leaf comes from the aquatic lotus plant in the Nelumbonaceae family. What are the Primary Effects? SREBP-1c, REE, a-glucosidase, GLUT4, AGEs: Keeping with the recurring theme of attacking pre-adipocyte differentiation, lotus leaf could be a potentially big player in this assault. Research has demonstrated the ability of lotus to decrease SREBP-1c and triglyceride accumulation during adipogenesis, increase lipolysis, and decrease adipocyte differentiation capacity. In a study out of Japan, researchers took the now hopefully familiar route of trying to fatten up mice and rats with and without lotus supplementation and measured various obesity related parameters. They found that the supplemented group was able to prevent fat gain as well as hepatic triglycerides, coupled with an inhibited ability to absorb lipids and an accelerated rate of fat oxidation and resting energy expenditure. A 2013 study out of Korea looked at the effect of lotus supplementation for 7 weeks in animals with diabetes. They found that lotus was an extremely potent inhibitor of an enzyme called a-glucosidase, which lowers the rate of glucose absorption and extends digestion time, leading to a lower post-prandial glucose response. The same study also demonstrated the ability of lotus to lower plasma triglycerides and total cholesterol. Inhibition of a-glucosidase has been shown to reduce triglyceride uptake into fat cells, decrease hepatic lipogenesis, favorably effect skeletal muscle GLUT4 receptor density density, and diminish the production of Advanced Glycation End products (AGEs). Defuse ingredient: Olive Leaf extract Where does it come from? Olive leaf extract (OLE) is derived from the leaves of the olive plant; we have selected an extract with a high potency of oleuropein, a phenolic compound with some interesting properties relating to prevention of fat gain. What are the Primary Effects? PPARy, C/EBPa, RQ, AGEs, Insulin, Glucose: We'll kick this one off with the current theme, OLE is yet another ingredient in the Defuse formula that prevents adipocyte differentiation through inhibition/downregulation of PPARy and C/EBPa. A study published in the Journal of Nutrition found that OLE supplementation increased V02, reduced myocardial oxidative stress, and lowered respiratory quotient (RQ- lower levels indicate more fat oxidation vs. carbohydrate oxidation). In another study published in Nutrition, researchers overfed two groups of rats for eight weeks, then gave one group OLE and continued to overfeed both groups for another eight weeks. The non-supplemented group developed metabolic syndrome, including elevated abdominal and liver fat, collagen accumulation in the heart and liver, elevated oxidative stress markers, abnormal cholesterol and impaired glucose tolerance. The group supplemented with OLE either improved or normalized all of those parameters, demonstrating a potent protective effect against overfeeding. In a brand new human study out of The University of Aukland, overweight men at risk for metabolic syndrome were given supplementation with OLE for 12 weeks; researchers noted a 15% improvement in insulin sensitivity along with an almost 30% improvement in pancreatic beta cell responsiveness (the cells that produce insulin). An improvement in fasting insulin and HbA1c was also noted in a previous human study with 79 diabetic adults. Finally, OLE is another ingredient in the formula that acts as an anti-glycation agent, reducing production of AGEs. Defuse ingredient: Galega officionalis Where does it come from? Galega officinalis is an herbaceous plant in the Faboideae family native to the Middle East, containing a potent compound called guanidine. Primary Effects AMPK, FAS, Acetyl-CoA, GLUT4, Glucose: Galega is going to contribute to fat gain inhibition through some familiar mechanisms, and looks to be quite a promising compound. It has been shown to activate AMPk, increase GLUT4 translocation, and increase skeletal muscle glucose uptake in vitro and in vivo. An animal study out of Glasgow again demonstrated AMPk activation, as well as inhibition of Acetyl-CoA carboxylase and FAS, increased fat oxidation, and a reduction in body weight. The most impressive research on galega looked at the effect of supplementation for 28 days on normal and obese mice and measured several parameters. In normal mice, supplementation caused weight loss and a voluntary reduction of food intake. Interestingly, after cessation of the supplement, food intake increased back to normal but the weight loss was maintained. The obese mice supplementing with galega also showed reduced food intake, and the researchers noted a "striking absence of body fat" during post-mortem examinations. Both groups showed a reduction in fasting blood glucose, and the obese group also showed a reduction in serum insulin. Defuse ingredient: Panax Ginseng Berry Extract Where does it come from? Panax ginseng berry extract (GBE) comes from Ginseng; a perennial plant from the Araliaceae family. What are the Primary Effects? AMPk, FAS, glucose, SREBP-1c: GBE has been shown to inhibit lipogenesis during overfeeding by suppressing FAS and SREBP-1c, while upregulating AMPk. Supplementation was also shown to reverse diet-induced blood sugar cholesterol elevations, while reducing hepatic glucose output. Several studies in obese and/or diabetic animals have demonstrated a favorable modulation of blood glucose, loss of body weight, and even pancreatic beta cell regeneration. Defuse ingredient: Forskolin 60% Where does it come from? Forskolin is a diterpene from the Coleus forskohlii plant. What are the Primary Effects? Forskolin is well known to effectively target cAMP in adipose tissue, which, among other things, mimics exercise and caloric restriction. A 12 week randomized, double-blind placebo study out of the University of Kansas found that forskolin supplementation caused a decrease in body fat and an increase in lean body mass compared to the placebo group Error: Reference source not found. The even better news is that this study only used a 10% extract; we have obtained a far more potent 60% extract for Defuse. It has also been suggested to help mitigate weight gain in overweight human subjects Error: Reference source not found. Defuse ingredient: Silibinin Where does it come from? Silibinin comes from milk thistle seeds, and is the main active component of silymarin. What are the Primary Effects? Most people are well aware of Milk Thistle's profound effect on liver health, but silibinin is included in Defuse for a different reason. ATGL, Insulin, FFA's, Resistin, TNFa, oxLDL: Silibinin is the first ingredient in the formula to upregulate something called adipose triglyceride lipase (ATGL), which is an enzyme responsible for initiating the breakdown of stored fat (triglyceride) inside the adipocyte. Silibinin has also been shown to reduce serum fatty acids, improve skeletal muscle insulin resistance, reduce visceral fat, downregulate resistin, and improve glucose metabolism by downregulating gluconeogenesis genes and supporting the Akt pathway. And for some bonus points, silibinin also inhibits oxidation of LDL particles, decreases lipid peroxidation and lowers TNFa. Defuse ingredient: Rosemary Leaf Extract (carnosic acid) Where does it come from? Rosemary is a Mediterranean perennial herb; the leaf extract is a source of a natural diterpene called carnosic acid. What are the Primary Effects? PPARy, C/EBP, Glucose, Gastric Lipase, Hepatic Lipase: Carnosic acid (CA) does pretty much everything you could ask from an anti-adipogenic compound. Again we're going after PPARy and C/EBPa inhibition, and CA has a unique effect on restructuring the ratios of different forms of C/EBPb, the combined result being inhibition of adipogenesis. A recent study out of Switzerland boasted some impressive results in overfed mice supplemented with Rosemary leaf extract for 50 days, showing almost a 60% reduction in fat gain and 40% reduction in hepatic triglyceride levels. The researchers determined this effect was likely due to an inhibition of pancreatic lipase activity, and concluded Rosemary extract "…can limit weight gain induced by a high-fat diet and protect against obesity-related liver steatosis". CA has been shown in several other studies to significantly reduce body weight and body fat in lean and obese individuals, lower triglycerides, total cholesterol and insulin, reduce visceral fat, improve liver enzymes, favorably modulate glucose and glucose tolerance, inhibit gastric lipase (thereby reducing fat absorption), and inhibit pre-adipocyte differentiation. Defuse ingredient: Stearoyl Vanillylamide (capsaicin analogue) Where does it come from? Stearoyl Vanillylamide (SV) is a non-pungent analogue of capsaicin, the active component of chili peppers. What are the Primary Effects? TrpV1, BAT, REE: If you've been paying attention to obesity research the past few years, you've likely heard of the transient receptor potential vanilloid (TrpV1). See the description in the intro of the article if you need a quick explanation. Multiple studies have demonstrated SV/capsaicin's ability to act as a potent TrpV1 agonist leading to decreases in body fat and increases in energy expenditure. Brown Adipose Tissue (BAT) has taken an interesting journey in the research over the years, and for a long time was suspected to be negligible in adult humans, and therefore an unfruitful target for obesity and weight loss. However, new research is showing we were likely wrong all along, and that BAT is indeed a "…regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders". SV has been shown to have a profound effect in several studies on BAT upregulation through TrpV1 binding Error: Reference source not found. The net effect of this BAT activation is a significant increase in fat oxidation and energy expenditure. Two recent meta-analyses looking at the summation of the data determined that capsaicin supplementation increases VO2, energy expenditure and fat loss in humans. Defuse supplement summary Psychologically and emotionally we need time off, and often that time off involves eating and drinking large meals with friends and family. While we want, and need, to participate we can often find our other, fitness-related, goals compromised. Defuse gives us a much-needed tool for physique enhancement. Defuse helps prevent fat gain that happens with occasional caloric surplus (vacation and Holidays), and short burst muscle gaining cycles. Incorporating Defuse strategically as directed will minimize fat gain and help to maintain your much-desired leanness. Recommended dosage As a dietary supplement, take 4 capsules 30 minutes prior to the largest meals of the day. WARNING Consult your physician before using this or any dietary supplement. Do not take if you are pregnant or breast feeding, elderly, chronically ill, have difficulty urinating due to prostate enlargement, or taking any prescription or over-the-counter medicine, including but not limited to antidepressants (such as MAO inhibitors), allergy medications, and medications for high blood pressure or other cardiovascular conditions. Discontinue use and contact your doctor if you experience dizziness, headache, nausea, or heart palpitations. KEEP OUT OF REACH OF CHILDREN. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Have I used the word unique much? Defuse is a product that you take about half an hour out from your largest meal of the day. Or you can just rock it before cheat meals if you’re cutting or just keeping your meal sizes small in general. I’ll pop some Defuse, wait about 10-15 minutes and take my GDA/nutrient partitioner of choice (fav. combo is SlinTensity + NaRALA) and then eat at that 30 min mark (and I personally take 500mg Metformin ahead of time, too). This is an excellent one to have on hand to keep fat storage down while eating more or rocking those cheat meals.
Eviscerate Smolder
There are 3 versions of Eviscerate: the OG version, Smolder, and Burn Free Forumla (BFF). Smolder is probably the most popular because there’s still a bit of a burning sensation, but not as strong as the OG (be careful where you apply it!). This is the topical that’s great as you’re already leaner and down to the last bit. It’s also great for localized application (e.g. on your delts for a shoulder lift day).
Gut Health
This is a probiotic that’s been around for a long time. Great option for you. I like to switch between this and Eupepsia from time to time.
MyoSynergy
I don’t know what to say about this one other than WOW. I was among the first to try it and it’s just phenomenal. Stacking this with X Factor (ArA) results in an incredible natty muscle-gaining, fat-burning stack. You will experience some of the worst/most intense DOMS (delayed onset muscle soreness) ever with either of these products, but especially with the combo. I actually joked and called it ROMS because it’s not even delayed; it’s rapid. This an X-Factor are hands down my favorite natty products out there. Great to bridge into PCT with, use during a natty run, or even add alongside your cycle (though I’d take advantage outside of cycling because it’s so awesome).
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