over the counter meds (asprin, tylenol)

[Solo]

Hey bros I just want to post this to kind of warn you about over the counter meds like NSAIDS (non steroidal anti-inflammatory drugs) such as asprin, ibuprofen, aleive, tylenol ect.

I don't know how many ppl know about the stuff they take so if you do, don't flame me I'm just trying to help you. I know alot of ppl take tylenol, asprin, ibuprofen ect. for aches and pains from lifting and especially when coming off cycle. This is fine and doctors suggest taking low doses of asprin for heart therapy and what not but this is whats happening when you take them.

NSAIDS (asprin, ibupro, etc) inhibit prostaglandin synthesis by inhibiting cyclooxygenase (COX 1, COX 2), an enzyme needed for prostaglandin synthesis from arachodonic acid. Prostaglandins are involved in inflammation as well as platlelet formation. COX 2 is the enzyme that lends itself to prostaglandin synthesis whereas COX 1 is involved in maintaining the gastric mucosa (stomach lining) NSAIDS like asprin and ibupro block both COX 1 and 2 so although the inflammation is being reduced the stomach is being damaged. Constant use of these drugs causes intestinal bleeding and ulceration of the stomach. Also, inflammation is a means for the body to heal itself. With no inflammation you get no or extremely slowed healing.

This is kind of the quick and dirty but I hope people are aware of this because it can be a huge problem. Also i'll clear up a myth. Spicey foods don't cause ulcers, they only aggravate them.

hope someone reads this

[IntensityX]

Re: over the counter meds (asprin, tylenol)

Originally posted by Solo
Hey bros I just want to post this to kind of warn you about over the counter meds like NSAIDS (non steroidal anti-inflammatory drugs) such as asprin, ibuprofen, aleive, tylenol ect.

I don't know how many ppl know about the stuff they take so if you do, don't flame me I'm just trying to help you. I know alot of ppl take tylenol, asprin, ibuprofen ect. for aches and pains from lifting and especially when coming off cycle. This is fine and doctors suggest taking low doses of asprin for heart therapy and what not but this is whats happening when you take them.

NSAIDS (asprin, ibupro, etc) inhibit prostaglandin synthesis by inhibiting cyclooxygenase (COX 1, COX 2), an enzyme needed for prostaglandin synthesis from arachodonic acid. Prostaglandins are involved in inflammation as well as platlelet formation. COX 2 is the enzyme that lends itself to prostaglandin synthesis whereas COX 1 is involved in maintaining the gastric mucosa (stomach lining) NSAIDS like asprin and ibupro block both COX 1 and 2 so although the inflammation is being reduced the stomach is being damaged. Constant use of these drugs causes intestinal bleeding and ulceration of the stomach. Also, inflammation is a means for the body to heal itself. With no inflammation you get no or extremely slowed healing.

This is kind of the quick and dirty but I hope people are aware of this because it can be a huge problem. Also i'll clear up a myth. Spicey foods don't cause ulcers, they only aggravate them.

hope someone reads this

I've also read that NSAIDS inhibits protein synthesis which would make that double trouble especially if you are trying to build muscle.

[cbr929]

Good post bro

[Solo]

they can also increase your blood pressure. Prostaglandins promote vasodilation which lowers blood pressure and NSAIDS block them. So if you're "on" and taking these meds be extra careful since water retention will increase your blood pressure as well.

[BossMann]

Re: over the counter meds (asprin, tylenol)

Originally posted by Solo
Hey bros I just want to post this to kind of warn you about over the counter meds like NSAIDS (non steroidal anti-inflammatory drugs) such as asprin, ibuprofen, aleive, tylenol ect.

I don't know how many ppl know about the stuff they take so if you do, don't flame me I'm just trying to help you. I know alot of ppl take tylenol, asprin, ibuprofen ect. for aches and pains from lifting and especially when coming off cycle. This is fine and doctors suggest taking low doses of asprin for heart therapy and what not but this is whats happening when you take them.

NSAIDS (asprin, ibupro, etc) inhibit prostaglandin synthesis by inhibiting cyclooxygenase (COX 1, COX 2), an enzyme needed for prostaglandin synthesis from arachodonic acid. Prostaglandins are involved in inflammation as well as platlelet formation. COX 2 is the enzyme that lends itself to prostaglandin synthesis whereas COX 1 is involved in maintaining the gastric mucosa (stomach lining) NSAIDS like asprin and ibupro block both COX 1 and 2 so although the inflammation is being reduced the stomach is being damaged. Constant use of these drugs causes intestinal bleeding and ulceration of the stomach. Also, inflammation is a means for the body to heal itself. With no inflammation you get no or extremely slowed healing.

This is kind of the quick and dirty but I hope people are aware of this because it can be a huge problem. Also i'll clear up a myth. Spicey foods don't cause ulcers, they only aggravate them.

hope someone reads this

Good post (subject), but this is/isn't true. Aspirin and Tylenol ARE NOT anti-inflamitories. They are analgesics that work on a completely different mechanism. They affect pain receptors and do nothing for inflamation.

Also, on NSAIDS, they do do the things you mention above, but the only way they would do those things at a level that would affect your protein synthesis would be if you took about 5000mg/day for several weeks....nobody in there right mind does that.

For overall treatment of ailments, Ibuprofen, ketoprofen et al. are better choices due to the fact they actually help alleviate what is causing the pain/discomfort and not just "mask" it like analgesics do.

My point, if you need to take something for a headache, joint pains, etc., take an NSAID and keep the dose below 2400mgs/day.

Helico Pylori is the most common cause of stomach ulceration...

Cheers guys

[mick-G]

How much of these anti-inflam does one need to take to cause these problems stated. My dr. said one asprin ed is good for platlid flow?

[BossMann]

A lot...like around 3000mgs and above.

Aspirin IS NOT AN NSAID. It is an acid analgesic. Your DR. is correct, but for what you speak the average 350mg aspirin tab is too much. You can get by just fine treating that with 100mgs.

[BossMann]

Re: Re: over the counter meds (asprin, tylenol)

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[mick-G]

Re: over the counter meds (asprin, tylenol)

Originally posted by Solo
Hey bros I just want to post this to kind of warn you about over the counter meds like NSAIDS (non steroidal anti-inflammatory drugs) such as ASPRIN, ibuprofen, aleive, tylenol ect.

So this statement about the asprin being NSAIDS not correct? One St. Joseph asprin is 325mg. So you saying i should take half pill? I just doing what the doc. said? one asprin ed. Do they make 100mg ones, haven't checked. Anyway, i just can't imagine take a couple ibuprophin ed will cause all this.

[BossMann]

Well, it is true if they are abused, but I mean really abused. Again, only the Ibuprofen and ketoprofen mentioned are NSAIDS. Since I am not your physician, take your family Doc's orders.

[mick-G]

I guess what i'm trying to say is the information that Solo posts is very misleading about NSAIDS. Yes if you take shitloads of asprin or ibupropin, yes you can have some problem, but if you take like two ibupropin ed you will have no problem and it will not affect the aas. Also, I don't not have any heart problems. My dr. suggest anyone over 25yrs to take an asprin ed to help in platlid movement. I think this thread information posted will cause alot of undue worry for many reading and is blowing it way out of proportion, IMO.

[Solo]

Yeah I know they exclude aspirin from NSAIDS now but it inhibits prostaglandin synthesis just the same. How can you say something that inhibits prostaglandin synthesis doesn't affect inflammation? Aspirin is an anti-inflammatory analgesic.

Yes it is the higher doses that are effective for inflammation but not 5g a day. And plenty of ppl do take it everyday and get ulcers. And yes I know Helicobacter pylori is a spirohete that causes ulcers as well.

Aspirin inhibits COX 1 as do the other over the counter NSAIDS. This was my point. It leads to irritation and eventual destruction of the gastric lining.

[Solo]

just curious bossman but what are your credentials? You wrote in your profile that you're a federal agent and your hobbies are busting roid heads. Thats an interesting occupation.

[mick-G]

Originally posted by Solo
Yeah I know they exclude aspirin from NSAIDS now but it inhibits prostaglandin synthesis just the same. How can you say something that inhibits prostaglandin synthesis doesn't affect inflammation? Aspirin is an anti-inflammatory analgesic.

Yes it is the higher doses that are effective for inflammation but not 5g a day. And plenty of ppl do take it everyday and get ulcers. And yes I know Helicobacter pylori is a spirohete that causes ulcers as well.

My problem with these statements is that it does not state how much and frequency to cause these conditions. I am just implying that it would take large amounts to cause these reactions, and it would depend by the individual taking them ie ( a person with past gastronomical problems, allergic reactions etc), I am not saying these statements are totally false, just very vauge and leads the reader into believing that any asprin or ibuprofin will lead to gastro problems. Using a blanket statement "And plenty of ppl do take it everyday and get ulcers as well" is a statement without validation. Any medications taken in excess over long periods of time will cause adverse reactions.

[BossMann]

Originally posted by Solo
just curious bossman but what are your credentials? You wrote in your profile that you're a federal agent and your hobbies are busting roid heads. Thats an interesting occupation.

That has been a joke from way back on fitnessboard days...As far as my credentials, I am a medicinal/peptide chemist that has done work in this very area for around two years now. I also have a personal healthcare background.

One major problem we have in the medical community today is we have physicians that do not know how to read research papers and then go write their on summaries that are way off. Some Dr.'s today, certainly not all, do not understand that there are many variable that affect things such as chemical interaction between other drugs and pre-existing conditions. These play a very significant role in ailments such as stomach ulcerations. Normal folks with normal stomachs almost never have any problems with Ibuprofen, et al.

My point was not to disrespect you, but to let you know that before those assumptions can be made, all varibles must be considered.