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SARMS 101 MK 677 Ibutamoren
MK677.pngMK-677-2.pngMK-677-3.jpeg
Note MK 677 is not a SARM
Chemical Name: C27H36N4O5S
Other Name(s): Ibutamoren Mesylate, MK-0677, L-163,191, L163191, Nutrobal, Oratrope, Crescendo
CAS: 159752-10-0
Powder Purity: >99% HPLC
Solubility: Water, DMSO, Ethanol, Propylene Glycol
Molar Mass: 624.77 g/mol
Chemical Formula: C27H36N4O5S
Short term storage (weeks): 0-4 °C under dry condition
Long Term Storage (months): -20 °C under dry condition
Shelf Life: At least 4 years if properly stored
Melting Point: 156 – 158 °C
Appearance: Off-white to beige fine powder, hygroscopic, acrid odor, acrid metallic taste
Biological half-life: 24 hours
Suggested Intake: 25-50mgs/day, dependent on goal
MK-677 (Ibutamoren) is a growth hormone secretagogue, which mimics the growth hormone. It also increases insulin-like growth factor 1 (IGF-1). Researchers have found MK-677 to help build muscle, reduce muscle wasting, increase bone density, and reverse aging.
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Mk-677 was found to work through all 4 of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
How it works: MK-677 increases growth hormone levels and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition. As a result, researcher have found that MK-677 can also affect these functions.
Intake: Due to its half-life, the suggested daily dose can be taken all at once
Recommended Cycle: 12-16 Weeks is optimal
Post Cycle Therapy (PCT): Not required
Side effects: Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677. Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.
Note MK 677 is not a SARM
Chemical Name: C27H36N4O5S
Other Name(s): Ibutamoren Mesylate, MK-0677, L-163,191, L163191, Nutrobal, Oratrope, Crescendo
CAS: 159752-10-0
Powder Purity: >99% HPLC
Solubility: Water, DMSO, Ethanol, Propylene Glycol
Molar Mass: 624.77 g/mol
Chemical Formula: C27H36N4O5S
Short term storage (weeks): 0-4 °C under dry condition
Long Term Storage (months): -20 °C under dry condition
Shelf Life: At least 4 years if properly stored
Melting Point: 156 – 158 °C
Appearance: Off-white to beige fine powder, hygroscopic, acrid odor, acrid metallic taste
Biological half-life: 24 hours
Suggested Intake: 25-50mgs/day, dependent on goal
MK-677 (Ibutamoren) is a growth hormone secretagogue, which mimics the growth hormone. It also increases insulin-like growth factor 1 (IGF-1). Researchers have found MK-677 to help build muscle, reduce muscle wasting, increase bone density, and reverse aging.
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Mk-677 was found to work through all 4 of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
How it works: MK-677 increases growth hormone levels and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release. GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition. As a result, researcher have found that MK-677 can also affect these functions.
Intake: Due to its half-life, the suggested daily dose can be taken all at once
Recommended Cycle: 12-16 Weeks is optimal
Post Cycle Therapy (PCT): Not required
Side effects: Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677. Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.
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