TweetSo I’m roughly 3 weeks on Metformin. I stayed consistently at the same weight for almost a week and dropped down to 247. That’s an 8 lb swing. For me most of this from what I understand is probably liver repair. I’ve had non alcoholic fatty liver since my abdominal surgery in 2018. It has been a ***** to lose weight more than likely do to fat oxidation just not in the cards.

I’m hoping this path continues.

Negatives? I do notice an issue with pumps. The workouts are still going strong but the pump will just be a little less. I’ve also noticed since I take my met with my family dinner and I train late usually in the 10pm to 1am range. If dinner is to close to training the pump struggles just a bit but to be honest it makes me push harder in the pursuit of said pump.

I take injectable b12, usually 1cc every 2 weeks but I started taking a. .5cc every 4-5days just to avoid the b12 drop.

I take ipam/cjc when I first wake up (fasted) and I don’t know how to tell if I’d have diminished igf but nothing feels off.

The problem with reading about Met is they always are about unhealthy patients. So with diminishing test levels, no igf, b12 failures…it seems that if they did a test group of longevity guys like me who are on hrt or more, b12 inj, and some for of gh uptick that none of these issues would be present?


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Originally Posted by 6p6

So I’m roughly 3 weeks on Metformin. I stayed consistently at the same weight for almost a week and dropped down to 247. That’s an 8 lb swing. For me most of this from what I understand is probably liver repair. I’ve had non alcoholic fatty liver since my abdominal surgery in 2018. It has been a ***** to lose weight more than likely do to fat oxidation just not in the cards.

I’m hoping this path continues.

Negatives? I do notice an issue with pumps. The workouts are still going strong but the pump will just be a little less. I’ve also noticed since I take my met with my family dinner and I train late usually in the 10pm to 1am range. If dinner is to close to training the pump struggles just a bit but to be honest it makes me push harder in the pursuit of said pump.

I take injectable b12, usually 1cc every 2 weeks but I started taking a. .5cc every 4-5days just to avoid the b12 drop.

I take ipam/cjc when I first wake up (fasted) and I don’t know how to tell if I’d have diminished igf but nothing feels off.

The problem with reading about Met is they always are about unhealthy patients. So with diminishing test levels, no igf, b12 failures…it seems that if they did a test group of longevity guys like me who are on hrt or more, b12 inj, and some for of gh uptick that none of these issues would be present?


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let me see if i can get my doc to send over the research he shared with me about it's effects on igf and reducing muscle growth. you can also look up the videos that both palumbo and scott stevenson on the topic. doc scott did an extensive one on the topic of metformin.

i will tell you that i did igf testing after 4 weeks on gh alone and my igf numbers were through the roof and on the same batch i did another 4 weeks after we started up met with my doc and it crashed my igf down to lower than it was when i wasnt on gh at all. we were just tinkering around with dosing and seeing if i could offset and control insulin sensitivity at the same time with met and gh together. i have yet to find anything to help with insulin sensitivity while on even low dose gh at 3-4ius daily other than no shit insulin. my numbers creep up even doing a shit load of cardio during prep at 90 mins on the stairs daily. so even lots of cardio doesnt help mine out at all. i have to use log or lantus while using gh to keep my insulin sensitivity. berb works a little bit but not enough for me