what is that drug called that is supposed to "refresh" insulin receptors??

[Governor]

I dont remebr where, but last night I was reading about some drug that is supposed to "refresh insulin receptors" I think it said. I was very tired so I really dont fully remeber. I think it may have been at bass' sight but looked and I couldnt find it.

some points I remember:

supposed to help one to become less insulin resistant.

the guy who wrote it thinks every human on earth should be taking it becuase it suposedly helps to prevent type 2 diabetes

anybody know the name of it??
where i read it??
thought on it??
anybody taking it?

[BullFX]

bro i dunno about insulin receptors but i had this article check it out..

Another Writing taken on www.nuclearnutrition.com

Clearing the Receptors

By Trevor L. Smith

The following information is for entertainment purposes only...Nuclear Nutrition does not condone the use of steroids or any other illegal drug. No liability is assumed by Nuclear Nutrition

A lot has been said in regards to clearing the receptors and I thought now would be a good time to delve into this subject and simplify things.

Basically, one must view the receptor sites as parking spaces.

Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger, fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the cook, who would in-turn make the food and the waitress would then bring the food to you and you would then begin eating which is the whole reason you came to the hamburger stand in the first place.

I think everyone can easily understand that. Which means everyone can easily understand all they need to know about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and explain what happens when you inject steroids and they begin to go to work.

Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can place them they must first find a parking space.

Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the system because they previously only dealt with what your body naturally produced. However, there are lots of extra parking spaces that can be utilized and so the steroids park themselves into these spaces.

Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!

The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of "DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the receptor spaces, if they are already taken up by old "dead cars" you are shit out of luck.....

This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors parking space.

This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in new muscle mass!

O.K. Trevor, I am with you so far, but what the **** can I do about it?

The answer is ...PLENTY!

First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is "too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars" you will have sitting in the receptor parking spaces which means NO MORE GROWING!

Now with this in mind, how can we help get the cars out of there?

Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time in this situation which is why it is important to utilize short courses that will cause less disturbance in the system, less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up the spaces.

That being said, it should be noted that even short course will pile up "dead cars" after a while and you should give yourself an extended clean out of 2 months at least once a year.

But Trevor, isn't there anything I can do to help speed the process?

Once again the answer is yes!

You can help speed the process up dramatically by increasing your metabolic rate...Speeding up the metabolic rate is akin to hiring extra tow trucks to clear out all those "dead cars" that are occupying the receptor sites!

Have you ever know a person who was much, much fatter than you and yet ate half as much?

These poor bastards think they were given the genetic shaft and try every diet fad imaginable only to stay fat. Their problem no longer lies in their eating habits--which is ironic--; it lies in their metabolism, which basically was shut down due to the excess eating and lack of exercise that got them fat in the first place. Once you understand this, you can easily control your weight for the rest of your life. But what the **** does this have to due with steroid receptor sites?

EVERYTHING!

The same thing I would prescribe someone whose metabolism has shut down due to obesity, is the same thing I would prescribe someone who's receptor sites are all clogged and is no longer making progress....INCREASE THE METABOLIC RATE!!

Below I will outline a few ways this can be achieved in the constraints of a 4 week Receptor Clearing Cycle follwing the completion of a Muscle Building Course using anabolics:

Diet: I suggest cutting back 300 calories below maintenance per day during a 4 week off time from your anabolic regime...I also suggest eating 6-8 small meals spread out from early morning to late at night. The higher the number of meals you eat, the more your body has to go to work and break down the food which causes the metabolic rate to increase.

Aerobics: Yet another tool in the battle to increase the metabolism, I would suggest low level aerobics 5 times per week 30 minutes per session.

Pharmacology: It is important that one does not have ANY anabolics that are active in the system during this time period.....make sure that you have had a good 4 weeks since your last shot of long acting compound before you embark on this 4 week receptor clearing cycle....otherwise you are wasting your ****ing time! That being said, I would suggest the use of the following compounds to help accelerate the Receptor Clearing Process:

1. D.N.P. -- Understand that this is a ****ing vicious poison and a component in T.N.T., and I do not suggest it's use at all, but to be fair I must admit that NOTHING can raise the metabolic rate like D.N.P. can. Because this is well known, there are many people that will want to try it...This being the case, D.N.P. should only be used in the following manner during this course: 3 days on, 4 days off at a dose of 4mg per kilogram of bodyweight taken before bed----have plenty of towels around and a fan to keep you cool!
2. Cytomel--T3 is another booster of metabolic rate which is why the fitness models live on this stuff...it keeps you engines running high and burns the fat right off....In this case, we are more concerned with the fact that it increases the metabolic rate. Suggested use is 75mcg -100mcg 5 days on 2 days off for the 4 week course

3. B.M.R. 10--I know, I know shameless plug right...well I don't care, in the past 3 weeks since this product has been released I have people calling me and emailing me telling me that this product blows the doors off every other thermogenic including, E/C/A, Clenbuterol and Cytomel, and Tenuate.....People actually think I put D.N.P. in this product. Trust me I did not, but I did formulate a product with 11 Basil Metabolic Rate increasing compounds that will make you hotter than an oven and melt the fat right off you. Again in this course we are more concerned with the metabolic increase this product will cause. Why hasn't anyone else come up with this formula...#1 All the other companies market to the general public which causes them water down there products #2 it is too expensive for their profit minded companies to justify it's production #3 They are not bodybuilders, I am and I know what works and what doesn not.

Doses: On the days you are NOT using D.N.P. have 4 caps before each of the first 5 meals.

* If you do not wish to use D.N.P.---which I think is the smarter approach as it is very dangerous---you can simply use the B.M.R. 10 on the days that you would be using D.N.P. In my opinion this is smarter, safer and will be just as effective.

There you have it...a brief simple lesson on your receptors and how you might go about keeping them free and clear so you can continue to Grow, Grow, Grow

[prolangtum]

You cant refresh androgen receptors, new ones are made every few hours

[YellowJacket]

Originally posted by prolangtum
You cant refresh androgen receptors, new ones are made every few hours

Agreed and to speed that process, well weight training will do it.

[prolangtum]

Kind of off on a tangent, i was doing a search at CEM about downregulation, and here is a great post by Jguns:

There is some evidence to support that AR's upregulate but there is nothing that proves they downregulate.I am also SICK TO DEATH of people comparing Beta receptors to Androgen receptors just because BR's downregulate, does NOT instantly meant hat AR's do the same thing! It shows a complete lack of understanding physiology to say so! I love how that board has a bunch of so called "experts" that perpetuate these myths without any proof. I am tired, so I am going to copy a quote originating with Bill Roberts which really sums up my opinions on this subject:

The concept that AR activity is measured by "gains" is simply ridiculous. The function of the activated AR is not to produce gains per se, but to increase protein synthesis. That will only result in gains if muscle catabolism is less than the anabolism. As muscle mass becomes greater, so does catabolism. At some point under any hormonal and training stimulus, equilibrium is reached, and there are no further gains. With high dose AAS use, that point is at a far higher muscle mass than if androgen levels are at only normal values. The concept that the steroids are "not working" for thebodybuilder who is maintaining 40 lb more muscular weight than he ever could achieve naturally, and who might even still be gaining slowly (but not as fast as in his first cycle) is, at best,an example of poor reasoning..

Moderate dose steroids, even though they are sufficient to saturate the AR, don’t take one as far as high dose steroids can. The difference cannot be substantially increased percentage of occupied receptors, since almost all are occupied in either case.

First, the question is, downregulation relative to what? What is the control?

Unfortunately, the control for in vivo studies is castration, not the normal state. The bodybuilder really doesn’t care if normal testosterone levels may result in fewer ARs for some cell types than would be seen with castration. We would not want to get castrated just to have more ARs than in the intact condition, if for no other reason than that the decrease in androgen level would be more significant than any possible increase in AR number.

In vitro studies have generally been done with zero androgen as the control, not normal androgen.

It cannot be projected that if AR number decreased as testosterone level was increased from zero to normal, that therefore it would continue to decrease as level was increased yet further. For example, the cause of this might be that there is a promotion mechanism increasing AR mRNA production as testosterone levels fall to zero. That would not mean that there would be any loss as testosterone levels increase past normal. Or if it is a repression mechanism that comes into play as testosterone levels rise past zero, that mechanism might be fully saturated by the time levels reach normal, and no further repression might occur as levels go past normal.

In fact, papers which report downregulation, even in their titles, often show in the actual data that the range of downregulation was entirely between zero and normal, or even zero and a subnormal level. Thus they give no evidence whatsoever of downregulation occurring with supraphysiological levels of androgen relative to normal levels.

[Paperboy]

PGF2a

[DickRenegade]

insulin drugs

here are some insulin drugs available from docs in america. i wouldn't mess with them unless i was diabetic b/c they act a lot longer than the insulin people occasionally shoot after workouts.

glyburide, glucotrol, glimepiride, diabinese (sulfonyulureas) = increases pancreatic islet beta cell secretion of insulin

rosiglitazone, pioglitazone = increases insulin sensitivity

glucophage (metformin) = decreases hepatic glucose production and intestinal absorption; increases insulin sensitivity

hope it helps some and i didn't list all of them.

dick

[Governor]

glucophage (metformin) = decreases hepatic glucose production and intestinal absorption; increases insulin sensitivity


thats the one. I coudnt think of any damn work but refrech and I thought that shit was wrong...what can you guys tell me about this drug?

[Drenten]

It is good stuff. Acts as somewhat of a partitioning agent.

Here is a good quick read on it: http://www.diabetesnet.com/diabetes_.../metformin.php

BTW – the tablets smell really odd.

[prolangtum]

glucovance should work better than glucophage

[HeHateMe]

good luck with the metformin...i tried that shit and it really tore me up, couldn't handle it

[prolangtum]

I just gotta find someone or a place that will sell me glucovance, supposed to have less sides and work better, probaly looking at an overseas pharm, oh well.

[The REAL Bobo]

Metformin? Booooooo


Effects of short term metformin administration on androgens in normal men.

Shegem NS, Nasir AM, Jbour AK, Batieha AM, El-Khateeb MS, Ajlouni KM.

National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan.

OBJECTIVE: To study the effect of metformin on androgens in normal men. METHODS: A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin. RESULTS: After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure. CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.

[Governor]

Originally posted by HeHateMe
good luck with the metformin...i tried that shit and it really tore me up, couldn't handle it

sorry so late.....what was wrong with it?

[Governor]

Originally posted by The REAL Bobo
Metformin? Booooooo


Effects of short term metformin administration on androgens in normal men.

Shegem NS, Nasir AM, Jbour AK, Batieha AM, El-Khateeb MS, Ajlouni KM.

National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan.

OBJECTIVE: To study the effect of metformin on androgens in normal men. METHODS: A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin. RESULTS: After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure. CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.

well that does really suck.