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I found some info about the new anti estrogen aromasin that I thought might be worth sharing. I'll post the whole study at the bottom but here are a few of the more interesting points:
Aromasin (exemestane)
1. Out of the list of possible sides, a negative effect on lipid levels is not indicated, contrary to that of Arimadex and Femera.
2. Aromasin permanently binds irreversibly to the active site of the enzyme causing its inactivation, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone.
Exemestane has no effect on other enzymes involved in the steroidogenic pathway.
3. It is the only FDA approved drug for treatment of estrogen related breast cancer whose disease has gotten worse after treatment with tamoxifen (Nolvadex).
4. Suppression of at least 95% was achieved at a 25-mg dose. Exemestane 25 mg daily reduced whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in some subjects, which is higher than that of the comparble Arimadex and Femera.
5. After a single dose of exemestane 25 mg, the maximal suppression of circulating estrogens occurred 2 to 3 days after dosing and persisted for 4 to 5 days. This means that daily intake for males is not a neccessity.
This is also based on studies that were done to FDA specifications so the validity is somewhat substancial. It seems like aromasin might be a healthy alternative to Adex/Ldex and Femara for those concerned with their cardiovascular health.
Aromasin (exemestane)
1. Out of the list of possible sides, a negative effect on lipid levels is not indicated, contrary to that of Arimadex and Femera.
2. Aromasin permanently binds irreversibly to the active site of the enzyme causing its inactivation, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone.
Exemestane has no effect on other enzymes involved in the steroidogenic pathway.
3. It is the only FDA approved drug for treatment of estrogen related breast cancer whose disease has gotten worse after treatment with tamoxifen (Nolvadex).
4. Suppression of at least 95% was achieved at a 25-mg dose. Exemestane 25 mg daily reduced whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in some subjects, which is higher than that of the comparble Arimadex and Femera.
5. After a single dose of exemestane 25 mg, the maximal suppression of circulating estrogens occurred 2 to 3 days after dosing and persisted for 4 to 5 days. This means that daily intake for males is not a neccessity.
This is also based on studies that were done to FDA specifications so the validity is somewhat substancial. It seems like aromasin might be a healthy alternative to Adex/Ldex and Femara for those concerned with their cardiovascular health.
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