tren...hard on kidneys???!!!!

[hongkongguy]

this one making me crazy as hell,i have been reading all the threads about it and they came out different answers,still can't solve this question!someone says it will,someone says it won't?????!!!!!!!

[prolangtum]

People who say it will are ignorant. Someone please explain how it is more harsh on the kidney than any other injectable? Its not. If your piss stinks or is discolored its because of the dyes in the pellets.

[hongkongguy]

um.......

[prolangtum]

?

[prolangtum]

Found this on Chad's Forum:

The genotoxicity of trenbolone, a synthetic steroid.

Richold M
Huntingdon Research Centre, Cambs, England

Trenbolone, a synthetic androgen is used as a growth promotant in animal husbandry. Because of its steroidal structure and properties it has been extensively evaluated in a series of in vitro and in vivo assays to assess its genotoxic and initiating properties. Both the parent molecule 17-beta-hydroxy-trenbolone and its metabolite 17-alpha-hydroxy-trenbolone, produced only in cattle, have been tested.

17-beta-hydroxy-trenbolone was not genotoxic in the Ames Salmonella/microsome assay, cytogenetics assays in human lymphocytes and CHO cells, a micronucleus assay in CHO cells, a DNA repair synthesis assay in HeLa cells, mammalian cell mutation assays with CHO and V79 cells, the mouse micronucleus assay, rat bone marrow or spermatogonial cytogenetics assays or in a test for initiators in the rat. In the mouse lymphoma cell mutation assay with L 5178Y TK+/- cells, equivocal responses were obtained, particularly at highly toxic concentrations.

With 17-alpha-hydroxy-trenbolone a weak positive response was obtained in the L5178Y Tk +/- assay, particularly at highly toxic concentrations. Negative results were obtained in the Ames Salmonella/microsome assay, the cytogenetics assays using both human lymphocytes in vitro and rat bone marrow in vivo, the DNA repair assay and in the CHO mammalian cell mutation assay. It was also negative in the in vivo test for initiators. From this extensive battery of data, and also taking into account published data on trenbolone, it is concluded that 17-alpha-hydroxytrenbolone and 17-beta-hydroxy-trenbolone are devoid of genotoxic activity and are not initiators of cancer."

What this essentially means is that Trenbolone has been run through a series of toxicity tests to determine its effects on humans since we get trace amounts of it via beef treated with implants - and the results were negative. Trenbolone is not overly toxic to kidneys or liver compared to other injectable preparations.

That BA is toxic is a non-issue at the volumes injected by bodybuilders, as it is a bacteriostatic in ALL injectable preparations.

This is Rea's response to that thought:

"The benzyl alcohol content of 1ml of testosterone cypionate is 9.45mg and this is true of most name brand testosterone preperations as well. Those that are compounded tend to contain slightly high concentrations. A 5% concentration would be approximately 50mg per ml...though the trenbolone kits actually commonly contain more (source dependent). Assuming that an athlete administered 1ml of testosterone propionate daily the weekly benzyl alcohol content would be under 70mg. In the case of trenbolone kit preperations, a daily ml administered would result in 350mg or more. Cough at the facts if you wish, but knowledge is power."

Alright, so 1000mg/kg of BA can potentially kill you. That is about 100,000mg for an average bodybuilder!

This information on Cypionate is on one specific brand where BA is a bacteriostatic agent at less than 1%, while the content of Benzyl Benzoate is 20% as a solvent. You will find that in most preparations, BA is used as the main solvent at 5%. The density of BA is listed as 1.045 g/mL, which in a 5% solution is just over 50mg - so no argument there, except that this is not in any way unique to Trenbolone as many of you who have used Mexican products can attest to. You would need to inject the equivalent of 2,000ml of solution to achieve a toxic dosage of BA as per the studies he himself referenced. Now I know he advocates pretty crazy dosages, but...if anyone is doing half a GALLON of Trenbolone in their cycles I think there would be a lot of other issues to be concerned with.

[hongkongguy]

thank...............................you........... .................bro!!!!!!!!!!

[Drenten]

Originally posted by prolangtum
People who say it will are ignorant. Someone please explain how it is more harsh on the kidney than any other injectable? Its not. If your piss stinks or is discolored its because of the dyes in the pellets.

I don’t need to read a 5000 word clinical essay to interpret my own blood tests.

Using Trenbolone does have a significant effect on my kidney functions.

Also, Trenbolone was considered to be harsh on the kidneys long before anyone was converting pellets.

[Bustanut]

Originally posted by Drenten
I don’t need to read a 5000 word clinical essay to interpret my own blood tests.

Using Trenbolone does have a significant effect on my kidney functions.

Just curious, are you taking creatine with the tren?

A buddy of mine who has never used gear, but used creatine had a kidney test done and the numbers returned made the doctor think he was having kidney failure. He has never used creatine since.

Anyway, I was just wondering if you might have been using other substances whiich may have skewed your tests somewhat.

[BigD]

Well I had an entire physical done by my dad while I was on tren/dbol. After 5 weeks of 50mg/day dbol, my liver totally within normal range on EVERYthing. After the same time of 100mg/ed fina, absolutely nothing wrong with kidneys, BP, HR, nothing at all. Healthier than almost any patient he'd ever seen. Not saying this is proof, just that you didn't give ANY proof of any kind about your kidneys. What was wrong, were they not working? Dark urine doesn't count. Were you taking lots of protein or creatine. You have far too many variables unexplained to blaim non-existant kidney problems on a drug that has no proven propensity to cause the aforementioned problems. I rest my case.

[prolangtum]

Originally posted by Drenten
I don’t need to read a 5000 word clinical essay to interpret my own blood tests.

Using Trenbolone does have a significant effect on my kidney functions.

Also, Trenbolone was considered to be harsh on the kidneys long before anyone was converting pellets.

Was it a tren only cycle? Prolly not.

[DiamondBling]

NO

[goliath.jr]

Originally posted by prolangtum
People who say it will are ignorant. Someone please explain how it is more harsh on the kidney than any other injectable? Its not. If your piss stinks or is discolored its because of the dyes in the pellets.

Then why don't you explain to me why I can't even drink a single beer without my kidneys aching while on tren? Explain to me why my kidneys will ache if I slack on my water intake.

[spidey]

My first cycle (last year) was fina (50 mg ed) and test prop (50 mg ed). I had my kidneys and liver checked once before cycle to establish baseline values and twice while on cycle (midway and at the end). My kidney and liver values never deviated from precycle values. My kidneys were totally uneffected.

-Spidey

[BigD]

You cannot "feel" your kidneys anymore than you can "feel" your liver. Both can be in complete failure and you won't feel a thing. You CANNOT say your kidney's were stressed b/c you "felt". Sorry, study some of the vaunted "evidence" you have and you'll find it's nothing more than hearsay and your own easily succeptible mind. Sorry, tren isn't kidney-toxic. Your turn Pro

[spidey]

Originally posted by goliath.jr
Then why don't you explain to me why I can't even drink a single beer without my kidneys aching while on tren? Explain to me why my kidneys will ache if I slack on my water intake.

The only way to tell if that was indeed your kidneys aching is to have a blood test. It could have just been lower back pumps, which are often confused with kidney pain.

Also, remember that some of the supplements (creatine being an excellent example) are hard on the kidneys. The amount of protein that most BB's eat is hard on the kidneys too. Now, throw in all the other AS you were stacking with the tren. Most, if not all, are eliminated partially by the kidneys (tren included). It just doesn't make a lot of sense IMO to blame one component of your diet/supplement regimin for all the pain and problems. It all goes together to form the problems you are having. No one (I think) is claiming that tren doesn't have the possibility of effecting the kidneys at all; just that it doesn't do so any worse or differently than any other injectable AS.

-Spidey