Originally posted by spidey
OK, I'm a little confused. Anadrol (oxymethalone) is not mentioned in that whole abstract. Neither are liver values for that matter. What, pray tell, does this have to do with it's hepatic toxicity relative to anavar?
-Spidey
OK, I'm a little confused. Anadrol (oxymethalone) is not mentioned in that whole abstract. Neither are liver values for that matter. What, pray tell, does this have to do with it's hepatic toxicity relative to anavar?
-Spidey
Compare Drug Toxicity at Equal Doses
It is important to note that comparisons of studies that showed a seeming lack of a negative effect of Oxandrin on liver enzymes with HIV(-) and HIV(+) people related to studies of Anadrol that showed a negative effect are not credible. When we consider that liver toxicity is a dose-related phenomena, and then consider that the typical doses that Anadrol has been used and studied at are often 100 mg per day, and the doses that Oxandrin has been used and studied at are usually about 10 to 15 mg per day, there is no credible way to use data from these studies to compare the potential for toxicity of the two steroids. To accurately compare them each steroid must be given at the same dosage to matched subjects.
The Grunfeld study that showed that Oxandrin caused elevated SGOT and SGPT enzymes raises questions about whether Oxandin is just as potentially toxic as any other steroid at higher doses.
Those who’ve had liver disease or are using protease inhibitors (especially Norvir) should have their liver function tested regularly while using any oral steroid and take liver protectants like evening primrose oil, silymarin, lipoic acid, glutamine, and N-acetyl-cysteine.
Also, because oral steroids can decrease the "good" HDL cholesterol and increase the "bad" LDL cholesterol, oral steroids can increase the risk of cardiovascular disease (CVD). If you use oral anabolic steroids consider taking 400 to 800 IU of Vitamin E, and 1,000 to 2,000 mg. of Vitamin C with each meal. These vitamin antioxidants help to protect cholesterol from the oxidation that is associated with CVD.
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