Aroma vs. Letro

[Testify]

Both are aromatase inhibitors.
Aroma is steroidal.
Letro is non-steroidal.

Based on articles I've read, the absence of Estrogen results in the cessation of growth in, or reduction of cancerous - or gyno-related masses in breast tissue. But how does this mechanism work - is there more to it than inhibiting Estro? Why is Letro recommended for the treatment of gyno, but Aroma is not? Anyone know?

[Fit2bLarge]

Re: Aroma vs. Letro

damn testi, you got no love on this post, here's a bump for ya

[edvedr]

Re: Aroma vs. Letro

i want to know the answer myself. i don't see why aroma wouldn't work just as well.

[BIGMOFO]

Re: Aroma vs. Letro

Who's your daddy?!?!?!?!

AROMASIN Tablets for oral administration contain 25 mg of exemestane, an irreversible, steroidal aromatase inactivator. Exemestane is chemically described as 6-methylenandrosta-1,4-diene-3, 17-dione. Its molecular formula is C20 H24 O2.

The active ingredient is a white to slightly yellow crystalline powder with a molecular weight of 296.41. Exemestane is freely soluble in N, N-dimethylformamide, soluble in methanol, and practically insoluble in water.

Each AROMASIN Tablet contains the following inactive ingredients: mannitol, crospovidone, polysorbate 80, hydroxypropyl methylcellulose, colloidal silicon dioxide, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, simethicone, polyethylene glycol 6000, sucrose, magnesium carbonate, titanium dioxide, methylparaben, and polyvinyl alcohol.

AROMASIN is an aromatase inactivator. When it binds to the receptor site of aromatase, it changes the protein forever. This change “turns off” the protein so that it can no longer make estrogen. (Remember: estrogen is what helps some breast cancer to grow.)

How is AROMASIN different from tamoxifen?
AROMASIN prevents estrogen from being made. In contrast, tamoxifen does not stop the body from making estrogen. Rather, it blocks estrogen itself on the cancer cell to prevent cancer growth.

How can AROMASIN help me?
AROMASIN can help lower the amount of estrogen in your body. In all, it can reduce the amount by up to 95%. Also, this treatment may stop or slow cancer in people who have been treated with tamoxifen, even when that medicine stopped working.

[BIGMOFO]

Re: Aroma vs. Letro

Both are aromatase inhibitors.
Aroma is steroidal.
Letro is non-steroidal.

Based on articles I've read, the absence of Estrogen results in the cessation of growth in, or reduction of cancerous - or gyno-related masses in breast tissue. But how does this mechanism work - is there more to it than inhibiting Estro? Why is Letro recommended for the treatment of gyno, but Aroma is not? Anyone know?

from waht i have read they BOTH are recomended. I think letro is tried first to supress estrogen and aroma is used to stop production of estrogen and tamoxifen ONLY blocks estrogen it doe not stop it being made at all!

[BIGMOFO]

Re: Aroma vs. Letro

If you want to read more!

http://www.pfizeroncology.com/aromasinAbout.asp

[SMILEY FACE]

Re: Aroma vs. Letro

good post mofo

[BIGMOFO]

Re: Aroma vs. Letro

good post mofo

thank you puddin :smiliecol

[Testify]

Re: Aroma vs. Letro

Thanks mofo. But after I read more about Letro, I started to wonder why Pheedno would tell me to use it - because I already have Aroma. I wonder if there is some other mechanism at work here regarding the use of Letro.

[edvedr]

Re: Aroma vs. Letro

ask pheedno and tell us what he says

[BIGMOFO]

Re: Aroma vs. Letro

Letrozole suppresses the production of estrogen. Letrozole is in a class of drugs known as aromatase inhibitors; it helps prevent formation of estrogen. Although estrogen is a hormone naturally produced by the body, it can stimulate and maintain the growth of certain types of cancer. Letrozole slows or stops the growth of cancer cells by decreasing the amount of estrogen produced


Letrozole is highly specific in inhibiting aromatase activity. Impairment of adrenal steroidogenesis has not been observed. No clinically relevant changes in the plasma levels of cortisol, aldosterone, 11-deoxycortisol, 17-hydroxy-progesterone, ACTH (adrenocorticotropic hormone) or in plasma renin activity were found in postmenopausal patients treated with 0.1 to 5 mg letrozole daily. The ACTH stimulation test performed after 6 and 12 weeks of treatment with daily doses of 0.1 to 5 mg letrozole did not indicate any attenuation of aldosterone or cortisol production. Thus, glucocorticoid or mineralocorticoid supplementation is not required.

Letrozole had no effect on plasma androgen concentrations (androstenedione and testosterone) among healthy postmenopausal women after single doses of 0.1, 0.5 and 2.5 mg, or on plasma androstenedione concentrations among postmenopausal patients treated with daily doses of 0.1 to 5 mg. These results indicate that accumulation of androgenic precursors does not occur. Plasma levels of LH and FSH are not affected by letrozole in patients, nor is thyroid function as evaluated by TSH, T 4 and T 3 uptake.

[edvedr]

Re: Aroma vs. Letro

thanks mofo

[tested]

Re: Aroma vs. Letro

so what one is better letro or aroma?

[BIGMOFO]

Re: Aroma vs. Letro

so what one is better letro or aroma?

From all that I read, aroma kills (prevents it from being made) estrogen the most!

[Slightly Enhanced]

Re: Aroma vs. Letro

I've posted this before---I found it on google


ORIGINALLY POSTED BY SUPERCHICKEN and stolen by tony touch from crankenstein

theres been a lot of talk on other boards about this lately, and a lot of bad information thrown out as well. i wanted to share the good info.

somone keeps posting how letrozole is the strongest and doesnt negatively affect cholesterol. this is not true. letrozole is NOT the strongest and it DOES negative affect cholesterol/lipid profile in a bad way.

aromasin(exemestane) is the best. this is why

both arimidex/ldex/anastrozole and femara/letrozole hurt your cholesterol. the way these 2 anti e's work is they inhibit the aromatase enzyme. by inhibiting the enzyme which converts testosterone to estrogen, you reduce or even come close to eliminating estrogen production. we need some estrogen to be healthy. the major drawback to this is without estrogen, your lipid profile gets ****ed.

exemestane works differently. it does not stop the body from producing estrogen. rather, it makes it so the estrogen is unable to bind to receptors by deactivating the binding enzyme. if the estrogen cannot bind, you simply will not get bloated or get gyno. the estrogen is crippled due to exemestane. however, since the estrogen is still floating around, it will not negatively affect your lipid/cholesterol profile.

anastrozole doesnt cause a rebound effect, and neither does exemestane, but letrozole does. this means after you stop the letrozole, your estrogen rebounds and goes pretty high for a while, eventually it normalizes. you can avoid this by tapering your letro dose down before stopping it, but that is a pain in the ass. higher than normal can mess many things up post cycle when you stop. since the hpta has a feedback loop is primarily controlled by estrogen, high estrogen will tell your hpta to produce less testosterone, because it thinks the high estrogen is caused by too much testosterone. this is fact. now post cycle, dont we want to raise our test levels, not lower them? of course! so rebounds are bad. if you use letro taper the dose off to zero over a couple weeks.

fyi- nolvadex(tamoxifen) is a SERM(Selective Estrogen Receptor Modulator). this means on certain tissue it can act antagonisticaly or agonistically. in the case of lipid profiles, it acts agonistically. so, running tamoxifen with your anti e's will IMPROVE your cholesterol profile even if not on cycle or using any gear or other anti e's. its just plain good for cholesterol.

one thing to keep in mind though when runing tamoxifen with letro. letro reduces blood levels of tamoxifen by over 50%. a study showed 2.5mg letro ed made nolva levels drop to 40% of what they were before adding letro. this does not mean you cant use tamoxifen with letro, it just means you need to use more, about double. 20mg of nolva will act like 8mg if running letro. so make sure you are aware of this because you will need to buy more nolva to compensate. this does not happen when mixing tamoxifen with anastrozole or exemestane, it only hppens with letro.

also, many people and myself experince a reduction of libido on letro. this doesnt happen w/ ldex or exmestane as far as i know, and in my own experience, and ive run all 3 quite a bit.

the best combo IS exemestane and tamoxifen together. your cholesterol will be as good as can be considering your on a cycle of steroids. the dose of aromasin will vary depending on the users needs and how much aromatizing gear is being taken. usually 10-25mg ed works well. run 10mg ed nolva to improve your cholesterol.

second best combo i feel is anastrozole(ldex) and tamoxifen. ldex dose ranges from usually .15mg ed to 1mg ed. run 10mg nolva ed to improve cholesterol.

thierd best is letro and nolvadex. letro doses usually range from 1-2.5mg ed. run 20mg ed nolva to improve cholesterol w/ letro.

you do not need to run nolva with any of these 3, i do recomend it though as it will improve cholesterol compared to using the anti e's alone without nolva.

so in order of strength, on a dose per dose basis(not mg per mg) aromasin is def the strognest, next is letro, and then ldex.

ive been running aromasin now for about 4 months, i wont switch back to ldex or letro. it works much better and its much healthier for cholesterol profiles.

i think we all need to stop only worrying about side effects that we can see visually. cholesterol KILLS many people around the world everyday(well not directly kills but leads to it). steroids are hrting us badly in this sense. steroids do mess our cholesterol up pretty badly, and we will pay for it later in life. now not many of us are going to stop using gear because of that, but we should at least take the proper other drugs to help minimize.

aromasin is only a little bit more expensive than ldex or letro, and its actually about the same price as many places sell ldex or letro for. but its more powerful and healthier. people spend money all the time on steroids which dont have as many side effects as some of the harsher, cheaper steroids. a few extra bucks for the proper anti e's is def money well spent.
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