Tren- Fat burning and "fina cough" both from prostaglandin metabolization

[xplode loadz]

oh shit my mistake guys..i think i was mistaking progesterone from prostaglandins ???

[XXXL]

great info. will this hold true for all products that raise your IGF?

[Big Cat]

Originally posted by prophet
nandrolone is shown to increase prostaglandin production.....tren is similar to deca and anyone who knows about these powerful hormones (prostaglandins) knows they burn fat..... pgf2a

Actually prostaglandin inhibition is one way to reduce fat, in fact the use of cyclo-oxygenase inhibitors like the various NSAIDS is common practice, just look at the thousand and one variations of ECA (Aspirin is an NSAID). Aspirin has been demonstrated to reduce obesity, but was without effect in lean individuals. That means prostaglandin modulation, one way or another, would have relatively little impact on fat loss. Their effects are very different not only from one to the other (PGI2 increases fatty acid oxidation via the PPARbeta receptor in muscle, while PGE2 has been known to reduce lipolysis in adipocytes) but even the same ones on different tissues.

Increased prostaglandin action probably results from lack of estrogen, rather than increased androgen, since estrogen is a COX inhibitor.

IGF-1 is even less likely to decrease fat loss since it works via modulation of the same receptor pathways as insulin, which promote adipogenisis. That's why they call it INSULIN like growth factor I. Increases in systemic IGF-1 also downregulate Growth hormone, which in contrast to IGF-1, is lipolytic.

This is also evident in the fact that hormones that display an uncharacteristic rise in IGF-1 (ie, higher than their androgenic capabilities would normally allows, like eg Dbol) generally result in more fat gain.

Does tren even burn fat ? I highly doubt it. There is no evidence or mechanism that would point to this. There is evidence that it causes less fat gain, and that could have multiple explanations. All of them very worthwhile to discuss, but none of them that will lead to a functional theorem.

[instynct999]

PGF2a which is the dominant prostaglandin increased through trenbolones mediation on these structures absolutely burns fat and causes adipose tissue apoptosis

it also absolutely cause a phlegming and 'coughing' in the respiratory tract

between the mediation/increase in PGF2a (both anabolic and lypolytic) and IGF-1 (again both anabolic and potentially lipolytic) tren marked causes an increase in LBM and a greater disposition than many AAS hormones in lypolisis

[instynct999]

to note i have never seen this attribute related to Deca as noted above

while Deca may exhibit this it is too a far smaller degree and not very prominent

[Big Cat]

Originally posted by instynct999
PGF2a which is the dominant prostaglandin increased through trenbolones mediation on these structures absolutely burns fat and causes adipose tissue apoptosis

First of all there is no such thing as a dominant prostaglandin. They are all pro-inflamatory cytokines released in varying situations to varying responses.

Having said that I would really love to see how you came to the conclusion that trenbolone directly elevates PGF2alpha, as I could find to data to that effect. Androgens generally lower PGF2alpha.

Aside from that TNFalpha increases adipose tissue apoptosis as well, yet i'm not going to start injecting myself with that. On the other hand norepinephrine reduces adipose tissue apoptosis, yet I am more prone to use that for fat reduction.

it also absolutely cause a phlegming and 'coughing' in the respiratory tract

Again I would like to see some data that trenbolone increases PGF2alpha in the respiratory tract.

between the mediation/increase in PGF2a (both anabolic and lypolytic) and IGF-1 (again both anabolic and potentially lipolytic)

There is nothing remotely lipolytic about IGF-1. It uses the same cascades as insulin does, resulting in an upregulation of adipogenic markers like SREBP1, PPARgamma and c/EBP alpha and beta, all known to increase adipocyte differentiation and proliferation. Reduction of IGF-1 on the other hand is very lipolytic, as it reduces feeback on growth hormone, which is lipolytic and increases free IGFBP-3, which has been linked to apoptosis in various tissues.

tren marked causes an increase in LBM and a greater disposition than many AAS hormones in lypolisis

No AAS contributes significantly to fat loss in lean individuals. In contrast, all of them reduce fat mass in obese or testosterone depleted individuals, including drugs like Anadrol.

[justgettinbig]

ok been reading aroud sight for a couple of week and dont really understand much about this post but i have a question. I did my first cycle three months ago duratest 250 1amp evry 5 days and mixed it with decca. I had great results and now i am off taking my rehab. but since cycle i have a anoying cough that will not go away. Any answers to this would greatly be aperciated. If this does not have anything to do with this post and i just misunderstood i am sorry.

[justgettinbig]

anybody????

[prophet]

what about M1T and prostaglandins?