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The new drug THG

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  • The new drug THG

    This is the DRUG the ball players are being questioned about ...I saw this on another board the other day i thought i'd share it with this board........


    SAN JOSE, Calif. - How do you find something, if you
    don't know what you're looking for? That was the
    challenge facing Dr. Don H. Catlin, the molecular
    pharmacologist at the University of California-Los
    Angeles who was handed a near-empty syringe with a few
    tiny droplets of a substance suspected to be a new,
    undetectable steroid used by some athletes. "It's
    tough," he said. "You're looking for something that is
    unknown. It's a needle in a haystack. And it could be
    nothing." Catlin's lab, the UCLA Olympic Analytical
    Laboratory, provides drug testing and research
    services to major sport organizations all over the
    United States and abroad. One of its specialties is
    steroids, banned substances proven to enhance
    performance by increasing muscle strength. But the
    search to identify the substance in the syringe,
    provided to the U.S. Anti-Doping Agency by a track and
    field coach who said athletes had found a new steroid,
    "was the first time we were ever really taxed to our
    limits," he said. Once a syringe is used, tiny
    droplets of fluid remain on its walls and plunger.
    Catlin's first step was to rinse the remnants of the
    mystery substance from the syringe with methanol, a
    chemical solvent. Then the substance was screened by a
    mass spectrometer, a powerful analytical tool that is
    used to identify chemical compounds. Each substance
    creates what chemists call its unique "fingerprint" -
    actually, an image that resembles a mountain-like
    profile of peaks and valleys. The substance from the
    syringe yielded a pattern of 20 to 25 peaks that fit
    no pattern ever seen before. "It didn't match anything
    we'd ever seen," Catlin said. "We had to scratch our
    heads and say hmmmmm." So they moved on to other
    tests, using different approaches. Over weeks, they
    were able to draw, on paper, the molecular structure
    of the substance. Its structure strongly suggested
    that it was a steroid, not a stimulant. Their interest
    continued to grow. "In this business, it's not enough
    to be 99 percent sure," said Catlin. "You have to
    prove it." The way to prove it was to build the
    substance themselves, based on the structure they had
    drawn. So they synthesized the chemical in their lab.
    Then they took their chemical, ran it through the mass
    spectrometer, and compared its fingerprint to that of
    the mystery substance. Bingo: A match. "They were
    identical. Now we knew what it was," he said. And
    "because of its molecular structure, it was clearly an
    anabolic steroid," he said. "I know a lot about what
    makes a steroid, and there is no question in my mind
    that it is - and that it could have beneficial
    effects" for performance. Even though the chemical is
    structured slightly differently from known steroids,
    it is close enough that the human body responds in the
    same way, Catlin said. The final challenge for
    Catlin's lab was to create a test that would detect it
    in athletes' urine. The chemical had eluded detection
    because existing tests didn't screen for it. Catlin
    mixed his lab-built substance with urine, then created
    a way to extract it from the thousands of other
    substances in urine. This was the basis of a test that
    can detect the substance - called tetrahydrogestrinone
    (THG) - based on its characteristic chemical features.
    THG is not a "pro-steroid" or "precursor steroid,"
    like many other performance-boosting substances on the
    market, Catlin said. Rather, "this is a stand-alone
    steroid," he said. Whoever created it knew enough
    chemistry to make changes that were so subtle they
    slipped through the radar, according to Catlin. "It's
    just a little different, not dramatically different.
    Whoever developed it deliberately tried to make it
    hard to find," Catlin said. "That is very clear."

    --------------------------------------------------------------------------------
    THG

    Tetrahydrogestrinone, or THG, is a designer steroid
    whose effects are probably similar to related classes
    of anabolic steroids. Users become bigger and
    stronger, says a leading expert, but it has side
    effects: "Men become more ladylike and women more
    manlike." Composed of 21 carbon atoms, 28 hydrogen
    atoms and two oxygen atoms, each molecule of THG is
    shaped "like a pretzel or popcorn," says Dr. Don
    Catlin, director of the UCLA Olympic Analytical
    Laboratory in Los Angeles. But that little molecule
    likely can dramatically alter cell functions in the
    bodies of athletes who use it. "THG is a typical
    anabolic steroid -- it'll make you bigger and
    stronger. "It'll also make hair grow on your face if
    you're a woman and make you balder if you're a man,"
    Catlin said in a phone interview Thursday. "A man's
    testicles will shrink and his breasts will grow, while
    a woman's breasts will get smaller. And your blood
    chemistry will get out of whack in ways it would take
    me a long time to explain." THG is definitely
    artificial, meaning that it was created by someone,
    somewhere. That's because there's zero evidence it
    exists in nature, Catlin explained. Routine tests for
    detecting anabolic steroids are "totally blind" to
    THG, Catlin said. One of his goals is to find an
    easier way to identify it in routine tests of
    athletes' urine -- more routine, that is, than his
    UCLA team's summer-long investigation into the mystery
    drug. This summer, Catlin's team members discovered
    THG when they noticed an odd-looking "peak" on a
    jagged pattern of 25 "peaks" on a computer printout
    from a device called a mass spectrometer. Each peak
    represented the spectral "signature" of a particular
    organic molecule, one of 25 molecules from a syringe
    that a concerned track and field coach sent early this
    summer to the U. S. Anti-Doping Agency (USADA), a
    nonprofit corporation responsible for drug testing of
    U.S. Olympic athletes. "We got the syringe in the
    middle of June. It took eight chemists (on our team)
    two months to figure out the first step -- namely,
    what it was," says Catlin, who has an M.D. from the
    University of Rochester and has run the UCLA lab since
    1982. After figuring out the molecular structure of
    THG, Catlin and his team successfully manufactured
    samples in the lab, he said. Typically, steroid
    molecules "have a certain (characteristic) structure.
    If I were to draw (THG) next to (a picture of)
    testosterone on a piece of paper, you'd say, 'Oh yes,
    I can see the similarity.' But the details are a
    little different." Although others have called it a
    "designer steroid," Catlin says he prefers to call it
    an NCE or "new chemical entity."

  • #2
    Interesting I have never heard of this before!

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    • #3
      some big name track athletes are in big, big trouble...

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      • #4
        THG has anti-e and anti-progesterone properties fro what I know so that Dr is full of shit and just giving negative publicity for the sake of his personal views on steroid use. You can tell by his tone. THG CANNOT cause gyno, period.

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        • #5
          he is stereotyping gear by saying that. it shows his ignorance but the general public beleives every work, steroids are evil and so are the people who use them.


          i heard the stuff is legal through some loophole about new compounds or something like that is that true.
          "SHIAT BIOTCH, thats a big ass!"

          A clear concience is a sign of a bad memory.

          husband of the year

          moose riding maple syrup drinking flanel wearing canuck wannabe


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          • #6
            I wish I knew. I'd love to get my hands on a ORAL trenbleone like substance that won't aggrevate my gyno!

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            • #8
              Its funny how two people can read something and come up with completely different views ....In my ipinion this 'DOCTOR " is just giving his view on THG AFTER ALL he's a doctor ....


              "A man's
              testicles will shrink and his breasts will grow, while
              a woman's breasts will get smaller. And your blood
              chemistry will get out of whack in ways it would take
              me a long time to explain."

              This is he's view and you really can't argue his opinion after all it's not he's job to recommend "POST CYCLE THERAPY" Now is it ? lololl

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              • #9
                thanks intimid8or3 that was a good thread

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                • #10
                  Originally posted by jack hust
                  thanks intimid8or3 that was a good thread
                  Thanks JH...

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                  • #11
                    that doc is a fuckin tool ,and that trenbolone dirivative ,is pretty much uselass to us,why bother ,we have tren ,its all media hype .

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                    • #12
                      damn good read!!

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                      • #13
                        That THG is just a weaker version of trenbolone

                        the benefit of THG is just that they couldn't find any THG in your body.

                        So THG is more for athletes who have drug tests, than bodybuilders like us.

                        Tren is way better then THG, that's why we never heard of an bodybuilder using that.

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                        • #14
                          Tren is way better then THG
                          Not trying to be funny, but how do you know that? Used it? Seen studies?

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                          • #15
                            Same goes to others who've said it's no use..... Why are people saying this?

                            Me personally, I know nothing about it.

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