does winny prevent progesterone gyno?

[pigmeat]

I used to hear alot of people claim that taking winny while on deca or fina,will help prevent gyno from it. The reasoning is, that winny fights for the same receptors as progesterone does,therefore preventing gyno. I have never seen any proof of this,but would be interested to hear your oppinions.

[johnnyboy845]

didnt do anything for me ran 50mg winnie a day with my fina but the soreness was no different than without the winnie.. I get sore everytime I run fina about 3 days into it and it goes away a week or so after I stop but never any growth just soreness

[mj23]

I got it while taking zambons

[TxLonghorn]

No, this is a myth that just won't seem to die.

[Campeon Del Mundo]

Winny does help me with my gyno. When i took winny only and nothing else, my lump decreased in size.

[jack hust]

nope cant see that

[pigmeat]

I had a hard time believing it too, but it was all over the boards years back,and the topic came up the other day again, so i wanted to see if anybody had any proof it worked. Thanks for the replys!

[jackdaddy]

From Bodybuilding.com:


The specificity of Winny however, lies in how it counteracts estrogenic side-effects such as gyno and excess water retention. First of all it's a 5-alpha reduced substrate. 5-alpha reduction breaks the double bond between positions 4 and 5, which is required for conversion to estrogen via aromatase, the primary enzyme for the manufacture of estrogen in males. Because some of these compounds nonetheless show some affinity for aromatase they may have some use in blocking estrogen from other steroids they are stacked with. Wether or not Winny acts in this way is not entirely sure. What has been a popular point of discussion with stanozolol is its suggested anti-progestagenic effects. The theory goes that Winny can bind and compete for a position at the progesterone receptor much like Clomid of Nolvadex would at the estrogen receptor, thereby inhibiting progestagenic effects. Now, progesterone can aggravate estrogenic side-effects by agonizing estrogen and it does play a role in gyno.

We also discussed that certain steroids may indeed stimulate and act at the height of the progesterone receptor including nandrolone and Norethandrolone. These hormones are also altered by it inducing a decrease in libido and a sense of lethargy and such, and eventhough they aromatize in lesser rates than some other steroids, they show an equal capability to cause estrogenic side-effects, particularly when stacked with other aromatizable compounds. Now there is evidence that Winny does indeed bind to the progesterone receptor1 and its users do not indicate the normal characteristics of progesterone stimulation, which bodes well for these anti-progestagenic properties. There is also some clinical data that it does aid in symptoms that require progesterone suppression2. Much in the way danazol was also successfully used. The one thing we shouldn't lose sight of however is in what rate it binds to the progesterone reception. There is no data on this. For all we know it couldn't bind strong enough to compete with nandrolone or norethandrolone. So its not wise to state that Winny is an anti-progestagin per se, but it does make Winny a good match for these products in stacks in any case.



References

1 Ellis AJ, Cawston TE, Mackie EJ., The differential effects of stanozolol on human skin and synovial fibroblasts in vitro: DNA synthesis and receptor binding., Agents Actions 1994 Mar;41(1-2):37-43

2 Brestel EP, Thrush LB., The treatment of glucocorticosteroid-dependent chronic urticaria with stanozolol., J Allergy Clin Immunol 1988 Aug;82(2):265-9




Whether this helps or not?.................

[pigmeat]

thanks jack!