nova and gains

[big boy20]

If I take nova while I am on gear, will it effect my gains???

[BullFX]

some say it does.. some say it doest.. i dont really think it does and if it does its just some of the bloat .. so its just water weight...


its better to be safe than sry right? so i would take 10mg ED throughout

[HeHateMe]

i assume u mean nolva...dunno if it hinders gains or not...some claim it does, others notice little effect...whats your cycle look like? you may not need to run it the length of your cycle, but just have it on hand in case symptoms of gyno appear

[Billy_Bathgate]

I say it may, but I say it may not signficantly. I always take (or try to) 10mg throughout. It will lower your total estrogen eventually (according to my bloodwork), but it can also act as a psuedo-estrogen which will benefit cholesterol levels (also have BW). I usually still use 25mg Aromasin though. High BP is in my fam and can be elevated from estrogen or edema.

[bigjim33]

hey billy, is aromasin like ldex? and how would you say it is better, ect?

[big boy20]

I am in my 2nd week of my cycle I frontloaded with prop150mg eod and i am doing 400mgwk deca and 400mg/wk cyp and i can feel the water already,I don't mind the water if nova is gone effect my gains but if it won't i will start taking some.

[Billy_Bathgate]

jim, Aromasin is a little differnt. It is an anti-estrogen, but its a whats called a suicidal inhibitor. Basically, once aromasin targets the aromatic enzymes, its effects on them are permanent or irreversal. You may have heard it called the aromatase inactivator. Also, some studies suggest that unlike Ari or Fem, once the drug is stopped taking, the effects of anti-aromatation are still present. I believe this relates back to its permanent anti-aromatation.

I find besides that, it is more effective. In my own experience, I would put 25mg Aromasin = 2mg Arimidex.

Aromasin also seems to be easier on the ol Cholesterol.


bigboy, in my opinion, nolva will not significantly decrease gains. This is kinda an impossible point to prove though.

I wouldnt be directly concerned with the water retention, but more with the blood pressure increase that may be caused from it. If you dont mind the bloat, just keep an eye on your BP and other e-related sides and ride it out.

[Massive1]

Here's a site for the ole nova http://www.geocities.com/MotorCity/Downs/2779/

[Billy_Bathgate]

LOL, your links busted but works if you manually type it in.

[jack hust]

i think it only affects water gains imo

[iamdwalrus]

Here's something about aromasin taken from Ulter's board

AROMATASE INHIBITORS.

--------------------------------------------------------------------------------
Aromasin - from http://www.centerwatch.com/patient/drugs/dru587.html
Aromasin, a new drug to treat post-menopausal advanced breast cancer in patients for whom treatment with tamofixen was ineffective, has been shown to inhibit the production of estrogen, upon which some breast cancer cells depend. Furthermore, studies indicate that Aromasin, which reduces the risk of tumor progression by 18 percent and the risk of death by 23 percent, is more beneficial than the hormone therapy, megestrol acetate.

In post-menopausal women, the principle source of estrogen comes from the conversion of adrenal and ovarian androgens to estrogens by the aromatase (exemestane) enzyme. For post-menopausal women with hormone-dependent breast cancer, Aromasin serves as an aromatase inhibitor. As a result, the concentrations of estrogen, on which breast cancer cells may depend, are lowered. This estrogen-depriving process nicknamed, "suicide inhibition," is irreversible. However, it does not affect other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.

Warnings/Precautions:

Aromasin should not be administered to premenopausal women. Neither should it be coadministered with estrogen-containing agents.

Pregnant women should not take Aromasin, as it could pose a potential hazard to the fetus, and could cause potential loss of the pregnancy.

Aromasin has not yet been tested for pediatric patients.

Clinical Results

A phase III, double blind, randomized study was conducted for 769 post-menopausal patients whose breast cancer had metastasized (spread). The study compared the effects of Aromasin versus those of megestrol acetate on survival, tumor reduction, and duration of disease stabilization. Patients taking megestrol acetate had a median survival (estimated time at which 50 percent of the patients were still alive) of approximately 28 months, while patients taking Aromasin had a median survival significantly longer than 28 months (p< 0.039). Moreover, the progression of cancer was delayed longer in patients taking Aromasin (4.7 months) than in patients taking megestrol acetate (3.8 months). Also, 15 percent of patients treated with Aromasin experienced at least a 50 percent or greater reduction in the size of the tumor or a complete disappearance of all known lesions. This suggested a possible advantage over the 12.4 percent of patients treated with megestrol acetate who experienced this effect, although the difference was not statistically significant. Finally, the regiment for taking Aromasin is one 25mg pill taken daily, versus the 40mg pill of megestrol acetate taken four times daily. Based on the study's results, researchers are confident that Aromasin provides greater benefit than megestrol acetate.

Side Effects

In clinical trials, any adverse effects were generally described as mild to moderate. Some Aromasin use was associated with low-grade nausea, hot-flashes, fatigue, increased sweating, and increased appetite. However, only 7.6% of patients experienced undesirable weight gain (lower than the rate caused by magestrol acetate).

Warnings/Precautions

Aromasin should not be administered to premenopausal women. Neither should it be coadministered with estrogen-containing agents. Pregnant women should not take Aromasin, as it could pose a potential hazard to the fetus, and could cause potential loss of the pregnancy.

Mechanism of Action

Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone. (FDA Label)

[iamdwalrus]

Anti-e's don't interfere with LBM gains. If you consider edema as gains then yes it does interfere.

[Auriflex]

Originally posted by Billy_Bathgate
I say it may, but I say it may not signficantly. I always take (or try to) 10mg throughout. It will lower your total estrogen eventually (according to my bloodwork), but it can also act as a psuedo-estrogen which will benefit cholesterol levels (also have BW). I usually still use 25mg Aromasin though. High BP is in my fam and can be elevated from estrogen or edema.

Were you using the Aromasin at the time of your bloodwork?

[rollon]

Does researchkits make liquid form of Aromasin? How about Gearedups guy?

[Billy_Bathgate]

At that imparticular test no, as I wanted to see what nolva alone woudl do.