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i want to find out what is out there that actually improves your genetics to grow. i have read that gh causes growth of new muscle cells, a new study came out showing that high doses of test causes growth of new satellite cells (not sure how that applies), and that tren kills cortisol receptors (or something along those lines).
does anyone have any studies/info about what ive mentioned or anything else??
Originally posted by BossDJ02 satellite cells as in the nerves system? can u post that study up trancedelt?
I think this is the one he was talking about. From what I've seen people post GH and IGF also cause a similar increase - but I haven't seen any direct evidence that its anything more than hypertrophy in muscles.
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men.
Sinha-Hikim I, Roth SM, Lee MI, Bhasin S.
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
Testosterone (T) supplementation in men induces muscle fiber hypertrophy. We hypothesized that T-induced increase in muscle fiber size is associated with a dose-dependent increase in satellite cell number. We quantitated satellite cell and myonuclear number by using direct counting and spatial orientation methods in biopsies of vastus lateralis obtained at baseline and after 20 wk of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of T enanthate. T administration was associated with a significant increase in myonuclear number in men receiving 300- and 600-mg doses. The posttreatment percent satellite cell number, obtained by direct counting, differed significantly among the three groups (ANCOVA P < 0.000001); the mean posttreatment values (5.0 and 15.0%) in men treated with 300- and 600-mg doses were greater than baseline (2.5 and 2.5%, respectively, P < 0.05 vs. baseline). The absolute satellite cell number measured by spatial orientation at 20 wk (1.5 and 4.0/mm) was significantly greater than baseline (0.3 and 0.6/mm) in men receiving the 300- and 600-mg doses (P < 0.05). The change in percent satellite cell number correlated with changes in total (r = 0.548) and free T concentrations (r = 0.468). Satellite cell and mitochondrial areas were significantly higher and the nuclear-to-cytoplasmic ratio lower after treatment with 300- and 600-mg doses. We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure.
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