Aromasin vs Arimidex - Cholesterol value changes

[SJR7674]

I have been using Arimidex at 1 mg per day and my HDL levels are going way down even though I am taking the cholesterol medication Lipitor.

Different members of the board have advised me to swith to Aromasin, because it blocks 90% of the estrogen as compared to 60-70% with Arimidex. I am actually more concerned with my cholesterol values than how much estrogen I can control (adding novadex is actually supposed to improve HDL values)

My question is this. How can Aromasin which blocks 90% of estrogen be any better, if not worse on your cholesterol values than Arimidex, which blocks 30% less estrogen. Since estrogen levels are one of the things that influence cholesterol levels, I don't see how Arimidex, Aromasin, or for that matter Letrozole be any different on values.

If this is the case, and someone can offer supporting documentation, it would definately be worth it for me to put in a call to my doc and make a change.

Thanks

[firstenrgy]

Good question! I haven't seen any studies on it. Just the parroting of what others say on the boards.
firstenrgy

[SJR7674]

Anyone?

[goliath.jr]

aromasin has no negative effects on blood lipid profiles. arimadex on the other hand does. the only thing keeping it under control for you right now is lipitor. aromasin is VERY potent stuff so use it sparingly...

[SJR7674]

If they both stop estrogen from being produced, what is the science behinds one having a negative eefect on lipid profiles and the other not. Estrogen is what is causing the fluctaution in lipid profiles, not the actual mediaction?

[new231]

This is unrelated, but on many hair loss sites the members say that arimidex has caused them significant hair loss. These members do not use steroids and were merely experimenting with using arimidex to prevent MPB and it had the opposite effect. If you need sites I can provide them for you.

[Maxhardc]

Interesting New:


Then National Library of Medicine mentions hair loss with testosterone as a "Less Common" side effect.

The Clinical profile for oxandrin doesn't mention it as a side effect at all.

The type of testosterone and your predisposition for hair loss would influence the percentage of risk. I don't think anyone really fully understands the mechanism of hair loss. I have heard some reports that hair loss is actually mediated by IGF-I.

The cases of hair loss that I have heard of came from some kids taking trenbolone. But I can't vouch for the accuracy of those anecdotal reports.

Max

[goliath.jr]

Originally posted by SJR7674
If they both stop estrogen from being produced, what is the science behinds one having a negative eefect on lipid profiles and the other not. Estrogen is what is causing the fluctaution in lipid profiles, not the actual mediaction?

estrogen does not cause a poor lipid profile...

taken from healthsquare.com:

High cholesterol is the best known of all the many threats to a healthy heart. When excess amounts of this waxy, fat-like substance build up along the walls of the arteries, you face a dramatically higher risk of a complete blockage, leading to a heart attack or stroke.

At normal levels, cholesterol is not a bad thing. On the contrary, it's an essential raw material used by the body to build cell walls and produce hormones such as estrogen and testosterone. The body produces its own supply of cholesterol in the liver, and it's found naturally in all animal products (such as meats, eggs, milk, and cheese). It poses a problem only when the body is unable to use or eliminate excessive supplies.

As one of a variety of fatty substances in the body, cholesterol is classified as a lipid. It is carried through the bloodstream attached to proteins, forming complexes called lipoproteins. There are two major types of lipoproteins: the low-density lipoproteins (LDL) commonly known as "bad" cholesterol, and the high-density lipoproteins (HDL) usually dubbed "good" cholesterol. It's the "bad" LDL cholesterol that tends to form deposits on the artery walls. HDLs, on the other hand, help to clear excess cholesterol from the bloodstream. The ideal situation to aim for, then, is a low level of LDL cholesterol, a high level of HDL cholesterol, and a moderate total of both.

Cholesterol is measured in milligrams per deciliter of blood. According to the National Cholesterol Education Program, a desirable target profile consists of:

A total blood cholesterol level of less than 200
An LDL level of:
less than 100 if you have heart disease
less than 130 if you're at risk of heart disease
less than 160 if your risk of heart disease is low
An HDL level greater than 40
You are generally considered at risk of heart disease if two or more of the following factors apply to you:

Cigarette smoking
High blood pressure
Low HDL cholesterol (below 40)
A family history of early heart disease (before 55 in a man, or 65 in a woman)
Your own age (over 45 if you're man, over 55 if you're a woman)

[smalls]

I can't say anything on the difference that aromasin has on cholesterol levels, but I would add 25-50mgs of clomid per day, that should help with cholesterol.

[ward cleaver]

Where can you get aromasin?

[Governor]

aromasin deactivates the binding enzyme. Estrogen has no where to bind to. Its still all there- thats why lipids arent affected, but it cant do anything becuase it cant bind.

[Pheedno]

Aromasin is an inactivator, A-dex is an inhibitor.

As Governor stated, Aromasin inacitivates the binding affinity from the estrogens to the ER

A-dex prevents conversion all together.



Using a SERM(Nolva) can help in stabilizing the negative effects from A-dex on the lipid panel, and it's still good to use a SERM for it's benfits even when using aromasin

[SJR7674]

Good answers gurs, thanks. I have recently added Nova to the mix and cut back on the Adex. Aromasin seems a little harsh and best left for very heavy bulking cycles.

[superchicken]

i dont why people always say aromasin is too strong, its all dose relative. if one is more potent, and you dont need more potent, just take less. its a very simple concept.

i personally dont take 25mg aromasin ed, cause i dont need that much. but i still take it over ldex or letro because its better for my lipid profile. 25mg is the dose used in clinical trials usually.

in clincial trials they uisualy use 1mg ed of anastrozole. that sure doesnt mean everyone on here uses 1mg ed. most i would say use .25mg ed. 1/4 the dose used in clinical trials. keep in mind aromsin isnt some mystery drug where you absolutely have to take the full dose. you can take a smaller dose to suit your individual needs.

[Governor]

Originally posted by superchicken
i dont why people always say aromasin is too strong, its all dose relative. if one is more potent, and you dont need more potent, just take less. its a very simple concept.

i personally dont take 25mg aromasin ed, cause i dont need that much. but i still take it over ldex or letro because its better for my lipid profile. 25mg is the dose used in clinical trials usually.

in clincial trials they uisualy use 1mg ed of anastrozole. that sure doesnt mean everyone on here uses 1mg ed. most i would say use .25mg ed. 1/4 the dose used in clinical trials. keep in mind aromsin isnt some mystery drug where you absolutely have to take the full dose. you can take a smaller dose to suit your individual needs.

I was thinking the same thing