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Immune System Differences in Men and Women
It's already known that sex hormones play a role in immune response. The female hormone estrogen increases immune system inflammation, and the male hormone testosterone decreases it. Men are more likely to get infections, and women have a better response to vaccines.
But these sex differences in health aren't black and white. Women can have an overactive immune system. When the immune system becomes overactive, it can cause a type of disease called autoimmune disease. Examples of autoimmune diseases include multiple sclerosis, rheumatoid arthritis, and lupus -- all diseases that are much more common in women.
Evolution and the Immune System
Finding a genetic link between high testosterone and low immune response raises the question of why nature would design the immune system to be influenced by hormone levels.
"Pregnancy may be part of the reason," says Davis. "We know that a woman's immune system needs to be turned up after pregnancy to protect her and her baby." A woman's immune system gets revved up by estrogen, and this hypervigilance may be what causes more frequent autoimmune disease in women.
Evolution may play a role, too, says Natan Bar-Chama, MD, director of male reproductive medicine and surgery at Mount Sinai Medical Center in New York City. "There could also be an evolutionary advantage for men to have a weaker immune response," he says. "A weaker immune response may have helped men survive trauma and injury, increasing their chances of survival."
This study "does not mean that men should not get flu shots. Less effective does not mean not effective."
Davis seems to agree. "During evolution, men would be more likely to clash violently with each other," he says. "A weaker response may be a disadvantage when it comes to infections, but an advantage when it comes to a severe immune response. We know that women are less likely to survive a severe immune response, called a cytokine storm."
What This Means for Men's Health
The study also raises the issue of flu vaccine effectiveness. "This was a sophisticated study that sheds light on the role of testosterone in the immune response of humans, but it is still a small study," says Dr. Bar-Chama. "It does not mean that men should not get flu shots. Less effective does not mean not effective."
The immune system is complicated and relies on a delicate balance to function well. "It may be that men benefit from a somewhat weakened, but not too weakened immune response," Davis says. "But men who take testosterone to boost their testosterone levels should take note." And, though the idea of boosting the immune system may seem exciting, the ability to actually do it has proved to be elusive.
On the other hand, "we know that low testosterone is linked to increased mortality in men due to bone health and cardiovascular health," Bar-Chama says. "So men who have low testosterone along with symptoms of low testosterone can benefit from testosterone restoration therapy."
How to Boost Immune System Health
"I am not aware of any vitamins or supplements that have been shown to boost the immune system," says Bar-Chama, "Good health is your best booster. That includes reducing stress and getting enough sleep." Other smart lifestyle suggestions:
Don't smoke.
Eat lots of fruits, vegetables, and whole grains.
Maintain a healthy body weight.
Get plenty of exercise.
Drink alcohol only in moderation.
Take steps to avoid infection, like washing your hands frequently and avoiding undercooked meats.
Keep up with your checkups and screenings.
Testosterone's role in the immune response of men may be to weaken it, but that may not be an all-bad thing. Men's increased susceptibility to infections may be an evolutionary tradeoff for better survival from massive injuries.
"There are still lots of mysteries when it comes to the immune system," Davis says. "This study opens up some new avenues for exploration."
study done in 2015
Everyday Health
It's already known that sex hormones play a role in immune response. The female hormone estrogen increases immune system inflammation, and the male hormone testosterone decreases it. Men are more likely to get infections, and women have a better response to vaccines.
But these sex differences in health aren't black and white. Women can have an overactive immune system. When the immune system becomes overactive, it can cause a type of disease called autoimmune disease. Examples of autoimmune diseases include multiple sclerosis, rheumatoid arthritis, and lupus -- all diseases that are much more common in women.
Evolution and the Immune System
Finding a genetic link between high testosterone and low immune response raises the question of why nature would design the immune system to be influenced by hormone levels.
"Pregnancy may be part of the reason," says Davis. "We know that a woman's immune system needs to be turned up after pregnancy to protect her and her baby." A woman's immune system gets revved up by estrogen, and this hypervigilance may be what causes more frequent autoimmune disease in women.
Evolution may play a role, too, says Natan Bar-Chama, MD, director of male reproductive medicine and surgery at Mount Sinai Medical Center in New York City. "There could also be an evolutionary advantage for men to have a weaker immune response," he says. "A weaker immune response may have helped men survive trauma and injury, increasing their chances of survival."
This study "does not mean that men should not get flu shots. Less effective does not mean not effective."
Davis seems to agree. "During evolution, men would be more likely to clash violently with each other," he says. "A weaker response may be a disadvantage when it comes to infections, but an advantage when it comes to a severe immune response. We know that women are less likely to survive a severe immune response, called a cytokine storm."
What This Means for Men's Health
The study also raises the issue of flu vaccine effectiveness. "This was a sophisticated study that sheds light on the role of testosterone in the immune response of humans, but it is still a small study," says Dr. Bar-Chama. "It does not mean that men should not get flu shots. Less effective does not mean not effective."
The immune system is complicated and relies on a delicate balance to function well. "It may be that men benefit from a somewhat weakened, but not too weakened immune response," Davis says. "But men who take testosterone to boost their testosterone levels should take note." And, though the idea of boosting the immune system may seem exciting, the ability to actually do it has proved to be elusive.
On the other hand, "we know that low testosterone is linked to increased mortality in men due to bone health and cardiovascular health," Bar-Chama says. "So men who have low testosterone along with symptoms of low testosterone can benefit from testosterone restoration therapy."
How to Boost Immune System Health
"I am not aware of any vitamins or supplements that have been shown to boost the immune system," says Bar-Chama, "Good health is your best booster. That includes reducing stress and getting enough sleep." Other smart lifestyle suggestions:
Don't smoke.
Eat lots of fruits, vegetables, and whole grains.
Maintain a healthy body weight.
Get plenty of exercise.
Drink alcohol only in moderation.
Take steps to avoid infection, like washing your hands frequently and avoiding undercooked meats.
Keep up with your checkups and screenings.
Testosterone's role in the immune response of men may be to weaken it, but that may not be an all-bad thing. Men's increased susceptibility to infections may be an evolutionary tradeoff for better survival from massive injuries.
"There are still lots of mysteries when it comes to the immune system," Davis says. "This study opens up some new avenues for exploration."
study done in 2015
Everyday Health
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