Sugar 9x more addicting than cocaine

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Curr Opin Clin Nutr Metab Care.*2013 Jul;16(4):434-9. doi: 10.1097/MCO.0b013e328361c8b8.

Sugar addiction: pushing the drug-sugar analogy to the limit.

Ahmed SH1,*Guillem K,*Vandaele Y.

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Abstract

PURPOSE OF REVIEW:

To review research that tests the validity of the analogy between addictive drugs, like cocaine, and hyperpalatable foods, notably those high in added sugar (i.e., sucrose).

RECENT FINDINGS:

Available evidence in humans shows that sugar and sweetness can induce reward and craving that are comparable in magnitude to those induced by addictive drugs. Although this evidence is limited by the inherent difficulty of comparing different types of rewards and psychological experiences in humans, it is nevertheless supported by recent experimental research on sugar and sweet reward in laboratory rats. Overall, this research has revealed that sugar and sweet reward can not only substitute to addictive drugs, like cocaine, but can even be more rewarding and attractive. At the neurobiological level, the neural substrates of sugar and sweet reward appear to be more robust than those of cocaine (i.e., more resistant to functional failures), possibly reflecting past selective evolutionary pressures for seeking and taking foods high in sugar and calories.

SUMMARY:

The biological robustness in the neural substrates of sugar and sweet reward may be sufficient to explain why many people can have difficultly to control the consumption of foods high in sugar when continuously exposed to them.

PMID:*23719144*DOI:*10.1097/MCO.0b013e328361c8b8

[PubMed - indexed for MEDLINE



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Re: Sugar 9x more addicting than cocaine

PLoS One.*2007 Aug 1;2(8):e698.

Intense sweetness surpasses cocaine reward.

Lenoir M1,*Serre F,*Cantin L,*Ahmed SH.

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Abstract

BACKGROUND:

Refined sugars (e.g., sucrose, fructose) were absent in the diet of most people until very recently in human history. Today overconsumption of diets rich in sugars contributes together with other factors to drive the current obesity epidemic. Overconsumption of sugar-dense foods or beverages is initially motivated by the pleasure of sweet taste and is often compared to drug addiction. Though there are many biological commonalities between sweetened diets and drugs of abuse, the addictive potential of the former relative to the latter is currently unknown.

METHODOLOGY/PRINCIPAL FINDINGS:

Here we report that when rats were allowed to choose mutually-exclusively between water sweetened with saccharin-an intense calorie-free sweetener-and intravenous cocaine-a highly addictive and harmful substance-the large majority of animals (94%) preferred the sweet taste of saccharin. The preference for saccharin was not attributable to its unnatural ability to induce sweetness without calories because the same preference was also observed with sucrose, a natural sugar. Finally, the preference for saccharin was not surmountable by increasing doses of cocaine and was observed despite either cocaine intoxication, sensitization or intake escalation-the latter being a hallmark of drug addiction.

CONCLUSIONS:

Our findings clearly demonstrate that intense sweetness can surpass cocaine reward, even in drug-sensitized and -addicted individuals. We speculate that the addictive potential of intense sweetness results from an inborn hypersensitivity to sweet tastants. In most mammals, including rats and humans, sweet receptors evolved in ancestral environments poor in sugars and are thus not adapted to high concentrations of sweet tastants. The supranormal stimulation of these receptors by sugar-rich diets, such as those now widely available in modern societies, would generate a supranormal reward signal in the brain, with the potential to override self-control mechanisms and thus to lead to addiction.

PMID:*17668074*PMCID:*PMC1931610*DOI:*10.1371/journal.pone.0000698

[PubMed - indexed for MEDLINE]*Free PMC Article



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Re: Sugar 9x more addicting than cocaine



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