Instant Access Registration Takes Less Than 15 Seconds! You May Not Post Until Registered.
To start viewing messages, select the forum that you want to visit from the selection below.
If you are having trouble staying logged in when navigating between forums/topics/etc., you need to reset your session cookie. Go into your browser and delete any cookie for the site them log back in. This should fix the login issue.
Announcement
Collapse
No announcement yet.
Lilly drug chosen for U.S.-sponsored Alzheimer's trial
Lilly drug chosen for U.S.-sponsored Alzheimer's trial
(Reuters) - Researchers have selected Eli Lilly and Co's experimental treatment, solanezumab, for a federally sponsored study of whether Alzheimer's disease can be slowed or prevented in older patients who have not yet developed significant memory problems.
Disclaimer: Steroid use is illegal in a vast number of countries around the world. This is not without reason. Steroids should only be used when prescribed by your doctor and under close supervision. Steroid use is not to be taken lightly and we do not in any way endorse or approve of illegal drug use. The information is provided on the same basis as all the other information on this site, as informational/entertainment value.
Re: Lilly drug chosen for U.S.-sponsored Alzheimer's trial
In my evolutionary medicine course I ask my students why only humans have this disease and it is not found in any of our closest evolutionary cousins the primates? (We share a lot of similar diseases with them but this is what distinguishes us from them).
That will be the key to unlocking the answer to this horrible disease.
The answer is the evolutionary constraint on perfection called Antagonistic Pleitropy. ( such as the ApoE4 gene).
The expression of genes linked to neurotransmission, neuroplasticity, axonal transport, aerobic metabolism and neuroprotection seems to have increased within the human cerebral cortex.However, high levels of neuroplasticity increase neuronal vulnerability later in life.
Some kind of dysfunction in these genes can disrupt proper regulation of a number of pathways that causes oxidative stress These genes the increased expression of advantageous genes at an early age could turn out to be harmful at an advanced age. Once we can unlock these genetic polymorphisms ( ApoE is one of them), we can design targetted drug therapy based on pharmacogenetics...
We process personal data about users of our site, through the use of cookies and other technologies, to deliver our services, personalize advertising, and to analyze site activity. We may share certain information about our users with our advertising and analytics partners. For additional details, refer to our Privacy Policy.
By clicking "I AGREE" below, you agree to our Privacy Policy and our personal data processing and cookie practices as described therein. You also acknowledge that this forum may be hosted outside your country and you consent to the collection, storage, and processing of your data in the country where this forum is hosted.
Tweet
Comment