NAD vs NAD+ vs NADH

[dirtwarrior]

I have been researching these compounds and still confused. Can someone shed some light on these?

[jipped genes]

Damn bro, I looked into them a while back and it was beyond my reckoning. NAD is the first and NAD+ is the oxidized form of it and NADH is the reduced form of NAD. But getting into cellular respiration and such is beyond me. Sorry.

[dirtwarrior]

TY jipped

[dirtwarrior]

NAD+ is a legal compound. Is it OK to ask some to brew it in this thread

[dirtwarrior]

I will do it myself if someone can message me details on how to do it.

[dirtwarrior]

What would be a good solvent?

[jipped genes]

Bro, I would just use distilled water, 0.2% BA and NAD. I do not know how well it suspends. May have to use EO or BB as a secondary solvent. Would love to see a home brew result.

on that note after responding to your original post I found that liposomal NMN is far better at raising NAD levels in the cells. (NMN is the precursor to NAD and is converted in the cell) Even better than inject NAD+. The reason? NAD+ is a very large molecule and is difficult to get into the cell where it can have it's beneficial effects on krebs cycle, telomere lengthening and ATP production. NMN is much smaller and is easily converted. No reason to pin if you do not have to. Liposomal supps have an affinity for the intestinal wall and can pass easily and even miss the first pass in the liver as it is pulled into the lymphatic system. (See below)

Please note there is so much contrary info on this stuff. I am not really sure but I would start with lipo NMN taken orally.


Liposomal delivery systems are commonly used to enhance the bioavailability of NAD+ precursors. These systems consist of microscopic vesicles composed of phospholipid bilayers, mimicking the structure of cell membranes [151]. The therapeutic agent is encapsulated and protected from degradation by enzymes and harsh conditions within the gastrointestinal tract. With structural similarities to cells lining the small intestine, liposomes can fuse with M cells within the small intestine, allowing entry into the lymphatic system and bypassing hepatic processing altogether [151]. Notably, studies in rats have demonstrated that the phospholipid bilayer of liposomes does not adversely affect blood lipid levels [152]. Encapsulated NMN is effectively taken up by cells in vitro and demonstrates enhanced absorption and tissue concentration in mice [153,154]. In a model of aging mice, oral administration of NMN encapsulated in ovalbumin-fucoidan nanoparticles significantly reduced oxidative stress, improved behavioral performance, and led to a 1.34-fold increase in NAD+ levels compared to free NMN administration [155]. The metabolic processing of common administration routes for NMN are depicted in Figure 3.

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[dirtwarrior]

great post

[jipped genes]

great post

Thank you for peaking my interest in it again. I had forgotten about NAD and it's like. We started using it when we went to Thai Land as it can reduce jet lag. I guess somewhere we stopped and I ceased using it.

[dirtwarrior]

I got some NAD+ liposomal very good so far.