glycocimine?

[jackjuice]

has any one heard of this new supplement? I read about it, and the artcle said it is good for people to take with creatine, if you don't see good results from creatine alone. It is supposed to work 95% of the time when used with creatine.
I was just wondering if anyone heard of it, And might know a little bit more about it.

[HeHateMe]

I've heard of glucosamine, not glycocimine. Glucosamine is supposed to be good for the joints, tendons, ligaments, etc.

[Blackfoot]

Re: glycocimine?

Originally posted by jackjuice
has any one heard of this new supplement? I read about it, and the artcle said it is good for people to take with creatine, if you don't see good results from creatine alone. It is supposed to work 95% of the time when used with creatine.
I was just wondering if anyone heard of it, And might know a little bit more about it.

Can't say I've heard about this one. Keep us updated.

[jackjuice]

I know what glucosamine is and what it is used for. Thanks though, HHM. I will keep you up dated on this when I hear more.

[HeHateMe]

Originally posted by jackjuice
I know what glucosamine is and what it is used for. Thanks though, HHM. I will keep you up dated on this when I hear more.

Please do. If you have any information on it, please post it.

[Slightly Enhanced]

Glycocyamine is the precursor of creatine. Glycocyamine is produced in the body naturally and is composed of a combination of amino acids. By supplementing with glycocyamine, you can prevent the suppression of endogenous creatine in those supplementing with creatine. It is also understand that supplementing with glycocyamine concurrently will increase creatine's positive muscle building and repair effects on the body. For those who have supplemented with creatine and not received a positive response, glycocyamine may be the key needed to jump start gains if taken at the same time.

http://www.bodybuildingpro.com/glycocyamine.html

HN==C(NH2)NH-CH2COOH; 2-guanidinoacetic acid;formed by the transfer of the amidine group from l-arginine to glycine.

It is found in these products:
ENDOCRE r3 (BBS Nutrition)

SWOLE V2 (Syntrax)

V12 (S.A.N.)

[Slightly Enhanced]

In summary. No. Don't waste your money

Glycocyamine – Is it a "Creatine-Enhancer?"

by Paul Cribb, B.H.Sci HMS
AST Director of Research

You many have read about a new compound called glycocyamine in the muscle magazines. Some supplement marketers are selling this product as a creatine enhancer.

What is Glycocyamine?

Glycocyamine is the intermediate step of creatine synthesis in the liver. It is often called guanidinoacetate. The first step in creatine synthesis occurs with the transfer of the amidino group of arginine to glycine to yield ornithine and guanidinoacetate via L-arginine:glycine amidinotransferase.[1]

Because of this, glycocyamine (guanidinoacetate) is often used in medical research as a marker for alterations in creatine metabolism and an indicator of conditions such as arginine-glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT) deficiencies.[2,3]

A reduction of guanidinoacetic acid in body fluids is desired for GAMT deficiency (an inborn error of creatine biosynthesis). These diseases are characterized by creatine depletion and accumulation of guanidinoacetate in the brain.[4]

Glycocyamine as a Supplement.

There are no direct studies on glycocyamine as a performance enhancing supplement or a creatine enhancer. Even more important to athletes, there is no theoretical research that even remotely suggests glycocyamine might enhance muscle growth or the effectiveness of creatine supplementation.

One study has examined the effects of supplementing with glycocyamine and creatine on physiological plasma homocysteine levels in rats.[5] It’s from this research that marketers of glycocyamine supplements seem to be drawing their “science-based” sales pitch on glycocyamine.

A number of studies have confirmed a relationship between an increased plasma concentration of homocysteine and the development of cardiovascular disease. Even a small increase in circulating homocysteine increases coronary artery disease risk by 60% for men and 80% for women.[6] Supplementation with creatine is suspected to decrease homocysteine levels.[7]

Because the methylation of guanidinoacetate to creatine via consumes more S-adenosylmethionine than all other methylation reactions combined, the researchers behind the rat study hypothesized that guanidinoacetate and creatine supplementation may have opposite effects on homocysteine levels. Results showed they did.[5] Creatine supplementation was shown to decrease liver homocysteine levels, thus substantiating the possibility of creatine as a supplement that may help people avoid cardiovascular disease. However, guanidinoacetate supplementation was shown to increase homocysteine levels. This is not a good thing if you want to reduce your risk of cardiovascular disease.[6]

Would glycocyamine be effective for bodybuilders?

To provide a theoretical answer this question, we must look at glycocyamine’s role in metabolism and the role of creatine supplementation. Firstly, remember that glycocyamine is an intermediate involved in creatine synthesis within the liver. Without the presence of supplementation the body only synthesizes a small amount of creatine (less than 2-grams) per day. However, from the research it is clear that creatine supplementation reduces the body’s need to synthesize creatine, therefore the role of glycocyamine would be virtually eliminated.[7]

Secondly, compare this to regular doses that bodybuilders supplement (5-20-grams per day). Glycocyamine has no biochemical role what so ever in creatine supplementation and accumulation in muscle. Therefore you can start to understand why glycocyamine would be fairly useless supplement for bodybuilders.

Finally, as muscle cells cannot manufacture creatine, any attempt to increase muscle glycocyamine content via supplementation in an effort to help increase creatine stores would obviously be useless. Also, creatine relies on a highly selective cell transporter, I can’t see how a non-insulin-stimulating compound like glycocyamine could enhance creatine uptake in muscle.

The bottom line . . .

Guanidinoacetate/glycocyamine’s role in the small amount of creatine synthesized by the body has nothing to do with creatine supplementation. Promoting glycocyamine as a supplement that enhances the effects of creatine supplementation is completely without practical or theoretical biological evidence.

While at present there is zero research on guanidinoacetate/glycocyamine’s effect on muscle growth or creatine supplementation, from a theoretical perspective, as I have shown you, I can’t see how glycocyamine supplementation would enhance the effectiveness of creatine supplementation.

It’s becoming commonplace in the supplement industry for marketers to select a little known obscure metabolite from biochemistry (it doesn't matter if the compound is completely irrelevant to bodybuilding), and hype it as a new “magic muscle building catalyst”. This seems to occur because supplement marketers are all too aware that bodybuilders are demanding science-based products.

The problem with this unscrupulous marketing approach is that it’s very difficult for anyone without a biochemistry major to decipher the “science” behind these bogus products (even then, most acedemics still can’t see through the smoke screen). What you can do as a consumer is ask to be provided with the full reports on the research cited. Ask for the clear facts and don’t be intimidated or impressed by scientific marketing spin.

From a research and theoretically-based perspective, the suggestion that glycocyamine is a creatine-enhancing supplement is at present, completely unfounded.

References:


1. Allain, P, LeBouil A, Cordillet E, LeQuay L, Bagheri H, and Montastruc JL. Sulfate and cysteine levels in the plasma of patients with Parkinson's Disease. Neurotoxicol 16: 527–530, 1995.

2. Carducci C, Birarelli M, Leuzzi V, Carducci C, Battini R, Cioni G, Antonozzi I Clin Chem 2002 Oct;48(10):1772-8. Guanidinoacetate and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate methyltransferase deficiencies. Clin Chem 2002 Oct; 48(10):1772–8.

3. Al Banchaabouchi M, Marescau B, Van Marck E, D'hooge R, De Deyn PP. Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice. Metabolism 2001 Dec; 50(12):1418-25.

4. Schulze A, Ebinger F, Rating D, Mayatepek E. Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. Mol Genet Metab 2001 Dec;74(4):413-9.

5. Lori M. Stead, Keegan P. Au, René L. Jacobs, Margaret E. Brosnan, and John T. Brosnan. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 281: E1095–E1100, 2001

6. Refsum, H, Ueland PM, Nygård O, and Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 49: 31-62, 1998.

7. M. F. McCarty. Supplemental creatine may decrease serum homocysteine and abolish the homocysteine `gender gap' by suppressing endogenous creatine synthesis. Med Hypotheses. Jan; 56(1): 5-7,2001.

[jackjuice]

Thanks bro!