Saw Palmetto

[HeHateMe]

Does it really have anti-DHT effects? Are there any studies documenting it's effectiveness, or is it all based on anecdotal evidence? Is it worth adding to your hair loss preventative stack?

[YellowJacket]

Re: Saw Palmetto

Originally posted by HeHateMe
Does it really have anti-DHT effects? Are there any studies documenting it's effectiveness, or is it all based on anecdotal evidence? Is it worth adding to your hair loss preventative stack?

Yes, SP is the real deal. I have a friend who uses it to block BPH. SP inhibits DHT assimilation so its good to prevent BPH and also good for your hair. Let me find my abstracts....

[YellowJacket]

Here's one on BPH, but through the same mechanism, it suppresses DHT, thus no hair loss....


Saw Palmetto Extracts for Treatment of Benign Prostatic Hyperplasia
A Systematic Review
Timothy J. Wilt, MD, MPH; Areef Ishani, MD; Gerold Stark, MD; Roderick MacDonald, MS;
Joseph Lau, MD; Cynthia Mulrow, MD, MS
JAMA. 1998;280:1604-1609

Objective.-To conduct a systematic review and, where possible, quantitative meta-analysis of the existing evidence regarding the therapeutic efficacy and safety of the saw palmetto plant extract, Serenoa repens, in men with symptomatic benign prostatic hyperplasia (BPH).

Data Sources.-Studies were identified through the search of MEDLINE (1966-1997), EMBASE, Phytodok, the Cochrane Library, bibliographies of identified trials and review articles, and contact with relevant authors and drug companies.

Study Selection.-Randomized trials were included if participants had symptomatic BPH, the intervention was a preparation of S repens alone or in combination with other phytotherapeutic agents, a control group received placebo or other pharmacological therapies for BPH, and the treatment duration was at least 30 days.

Data Extraction.-Two investigators for each article (T.J.W., A.I., G.S., and R.M.) independently extracted key data on design features, subject characteristics, therapy allocation, and outcomes of the studies.

Data Synthesis.-A total of 18 randomized controlled trials involving 2939 men met inclusion criteria and were analyzed. Many studies did not report results in a method that permitted meta-analysis. Treatment allocation concealment was adequate in 9 studies; 16 were double-blinded. The mean study duration was 9 weeks (range, 4-48 weeks). As compared with men receiving placebo, men treated with S reperis had decreased urinary tract symptom scores (weighted mean difference [WMD], -1.41 points [scale range, 0-19] [95% confidence interval (Cl), -2.52 to -0.30] [n = 1 study]), nocturia (WMD, -0.76 times per evening [95% Cl, -1.22 to -0,32] [n = 10 studies]), and improvement in self-rating of urinary tract symptoms; risk ratio for improvement (1.72 [95% Cl, 1.21-2.44] [n = 6 studies]), and peak urine flow (WMD, 1.93 mUs [95% Cl, 0.72-3.14] [n = 8 studies]). Compared with men receiving finasteride, men treated with S repens had similar improvements in urinary tract symptom scores (WMD, 0.37 International Prostate Symptom Score points [scale range, 0-35] [95% Cl, -0.45 to 1.19] [n=2 studies]) and peak urine flow (WMD, -0.74mUs [95%Cl, -1.66toO.18] [n=2 studies]). Adverse effects due to S reperis were mild and infrequent; erectile dysfunction was more frequent with finasteride (4.9%) than with S repens (1. 1 %; P<.001). Withdrawal rates in men assigned to placebo, S repens, or finasteride were 7%, 9%, and 11 %, respectively.

Conclusions.-The existing literature on S repens for treatment of BPH is limited in terms of the short duration of studies and variability in study design, use of phytotherapeutic preparations, and reports of outcomes. However, the evidence suggests that S repens improves urologic symptoms and flow measures. Compared with finasteride, S repens produces similar improvement in urinary tract symptoms and urinary flow and was associated with fewer adverse treatment events. Further research is needed using standardized preparations of S repens to determine its long-term effectiveness and ability to prevent BPH complications.

[Tinfish]

Damn YJ

a humble, a complimentary and now an informational post all in one day? you got most of us beat by 2 easily. me by 3

[YellowJacket]

Originally posted by Tinfish
Damn YJ

a humble, a complimentary and now an informational post all in one day? you got most of us beat by 2 easily. me by 3

Take a screen shot, this is VERY rare

[HeHateMe]

Thanks for the info, YJ...

You're an encyclopedia of knowledge, especially when it comes to supplements.

I guess I'll be calling up DPS and ordering a few bottles of SP to add to my stack.

P.S. pro-hormones still suck! LoL

[YellowJacket]

Originally posted by HeHateMe


P.S. pro-hormones still suck! LoL

Oh boy......

[labrad]

ph/ps do not suck. They are not as good as AAS, but that does not mean they suck. I always take saw palmetto when on a ph/ps cycle. Oh yeah, YJ is a f*cking encyclopedia of knowledge.