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Understanding depression and locked in negative behaviors has just reached an exciting new level of possibilities. In a research study, published just days ago, scientists explored the link of major depression, cognitive inflexibility, and rumination and found a disrupted mechanism linked to certain a methylation gene and folate. The study suggests that a change in this process leads to rumination or the stuck, stubborn, inflexible thinking and behavior.
Researchers found that one of the genes, MTHFD1L A allele rs 11754661, was found to increase depression and rumination problems. This gene is involved with the folate pathway found within mitochondria and reflects impaired folate function and methylation problems. This is the first known study on this specific mechanism. The authors were excited about the direction provided by the information and recommended further study of this pathway.
For individuals struggling with rumination, i.e. they cannot get their mind off of something, especially when associated with clinical depression, folate metabolism problems appear to be a significant problem. Unless you have had your DNA analyzed through one of the commercial gene profiles available with thorough analysis, the average person will not know if this gene pathway and mechanism is impaired or not. If you or a family member, however, have symptoms of depression and rumination, a powerful yet simple solution may be taking supplemental folate.
With impaired folate and methylation status, in order to bypass this metabolic problem, daily intake of dark green leafy vegetables and other folate rich foods is a must. Those who struggle with a locked-in problem may require significantly more than what the diet can provide. This makes it essential to supplement with folate in its methylated form in order to bypass the barriers from methylation defects. In fact, all Wellness Resources supplements that contain folate provide it in the methylated form, 5-Methyltetrahydrofolic acid, for optimum health benefits.
Depression disorders, cognitive health, and brain development rely heavily on adequate folate. It appears that researchers have discovered the malfunctioning pathway and gene related to improper folate and a stuck, rigid, ruminating depression. Perhaps the characters in the movie “Grumpy Old Men” or aging parents, preschoolers or teenagers who struggle with rumination, negativity, and depression may have this altered gene pathway and need some extra help. This information becomes even more striking in those with malnutrition, prenatal health, and those with eating disorders. This study may just help provide information to unlock that stuck ruminative behavior thus reducing the burden of struggle on the sufferer and those around that individual.
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Researchers found that one of the genes, MTHFD1L A allele rs 11754661, was found to increase depression and rumination problems. This gene is involved with the folate pathway found within mitochondria and reflects impaired folate function and methylation problems. This is the first known study on this specific mechanism. The authors were excited about the direction provided by the information and recommended further study of this pathway.
For individuals struggling with rumination, i.e. they cannot get their mind off of something, especially when associated with clinical depression, folate metabolism problems appear to be a significant problem. Unless you have had your DNA analyzed through one of the commercial gene profiles available with thorough analysis, the average person will not know if this gene pathway and mechanism is impaired or not. If you or a family member, however, have symptoms of depression and rumination, a powerful yet simple solution may be taking supplemental folate.
With impaired folate and methylation status, in order to bypass this metabolic problem, daily intake of dark green leafy vegetables and other folate rich foods is a must. Those who struggle with a locked-in problem may require significantly more than what the diet can provide. This makes it essential to supplement with folate in its methylated form in order to bypass the barriers from methylation defects. In fact, all Wellness Resources supplements that contain folate provide it in the methylated form, 5-Methyltetrahydrofolic acid, for optimum health benefits.
Depression disorders, cognitive health, and brain development rely heavily on adequate folate. It appears that researchers have discovered the malfunctioning pathway and gene related to improper folate and a stuck, rigid, ruminating depression. Perhaps the characters in the movie “Grumpy Old Men” or aging parents, preschoolers or teenagers who struggle with rumination, negativity, and depression may have this altered gene pathway and need some extra help. This information becomes even more striking in those with malnutrition, prenatal health, and those with eating disorders. This study may just help provide information to unlock that stuck ruminative behavior thus reducing the burden of struggle on the sufferer and those around that individual.
More...
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