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Researchers at the University of Arizona continue to methodically build the case for limonene in the prevention and treatment of breast cancer. In their most recent study women with operable early-stage breast cancer were given 2,000 mg of d-Limonene per day for 2-6 weeks prior to surgery.
Last year, in my article D-Limonene: Help for Digestion, Metabolism, Detoxification, Anxiety & Breast Cancer Prevention, I explained the foundational and very promising d-Limonene research of the past decade for a variety of health issues including breast cancer prevention.
One important research topic is showing that a nutritionally relevant dose of d-Limonene actually reaches breast tissue. In the current study, researchers were able to demonstrate that 2,000 mg per day resulted in significant d-Limonene accumulation in breast tissue.
They also demonstrated in these women with early-stage breast cancer that d-Limonene reduced by 22% a gene signal within the breast tumor known as cyclin D1, a hijacked gene signal that helps cancer grow. Since cancer must have rapid cell division to survive, the reduction in cyclin D1 should lead to cancer cell death and reduced rate of cancer proliferation.
This study proves that supplemental d-Limonene does accumulate in breast tissue and does have a specific mechanism of biological activity supportive of breast cancer prevention and tumor shrinkage. This study did not prove that d-Limonene could shrink or get rid of breast cancer, as this was not the objective of the study.
Building a scientific case for a nutrient in the prevention and treatment of breast cancer is a long and expensive process. There is no Big Pharma drug that will drive billions in sales. The University of Arizona and its donors are footing the bill for this research, hoping to build a case for a larger clinical trial that may be eligible for government funding. In the meantime, d-Limonene has adequate science to support a variety of health topics and can readily be incorporated by any woman wishing to add it to her nutrient team for general health purposes.
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Last year, in my article D-Limonene: Help for Digestion, Metabolism, Detoxification, Anxiety & Breast Cancer Prevention, I explained the foundational and very promising d-Limonene research of the past decade for a variety of health issues including breast cancer prevention.
One important research topic is showing that a nutritionally relevant dose of d-Limonene actually reaches breast tissue. In the current study, researchers were able to demonstrate that 2,000 mg per day resulted in significant d-Limonene accumulation in breast tissue.
They also demonstrated in these women with early-stage breast cancer that d-Limonene reduced by 22% a gene signal within the breast tumor known as cyclin D1, a hijacked gene signal that helps cancer grow. Since cancer must have rapid cell division to survive, the reduction in cyclin D1 should lead to cancer cell death and reduced rate of cancer proliferation.
This study proves that supplemental d-Limonene does accumulate in breast tissue and does have a specific mechanism of biological activity supportive of breast cancer prevention and tumor shrinkage. This study did not prove that d-Limonene could shrink or get rid of breast cancer, as this was not the objective of the study.
Building a scientific case for a nutrient in the prevention and treatment of breast cancer is a long and expensive process. There is no Big Pharma drug that will drive billions in sales. The University of Arizona and its donors are footing the bill for this research, hoping to build a case for a larger clinical trial that may be eligible for government funding. In the meantime, d-Limonene has adequate science to support a variety of health topics and can readily be incorporated by any woman wishing to add it to her nutrient team for general health purposes.
More...