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A study of cells from Down syndrome patients has shown that the active compound in green tea, EGCG (epigallocatechin-3-gallate), can significantly offset impairment to the energy-producing malfunction of these cells. Importantly, the multiple mechanisms of improvement are all associated with gene signaling that promotes longevity, a finding of broad interest to the general public.
During aging energy production within cellular engines (mitochondria) goes through a series of adverse changes that cause energy production inefficiency and aging. This includes increased free radicals that damage the mitochondria along with impaired gene function for stress tolerance and rejuvenation.
EGCG was found to significantly change all adverse functions of the cells. It essentially gave them a potent boost of anti-aging. Free radical levels were reduced. Longevity gene signals such as SIRT1, AMPK, and PGC-1a were all activated. The net result was significant energy improvement and mitochondrial biogenesis, which means that new mitochondria were generated due the overall production of a rejuvenation mode.
It is not known what doses of EGCG humans need to approximate these results. Previous human studies have shown the ability to boost AMPK. This type of study indicates that many anti-aging benefits likely occur from higher amounts of EGCG intake.
More...
During aging energy production within cellular engines (mitochondria) goes through a series of adverse changes that cause energy production inefficiency and aging. This includes increased free radicals that damage the mitochondria along with impaired gene function for stress tolerance and rejuvenation.
EGCG was found to significantly change all adverse functions of the cells. It essentially gave them a potent boost of anti-aging. Free radical levels were reduced. Longevity gene signals such as SIRT1, AMPK, and PGC-1a were all activated. The net result was significant energy improvement and mitochondrial biogenesis, which means that new mitochondria were generated due the overall production of a rejuvenation mode.
It is not known what doses of EGCG humans need to approximate these results. Previous human studies have shown the ability to boost AMPK. This type of study indicates that many anti-aging benefits likely occur from higher amounts of EGCG intake.
More...