The new drug THG

[INTIMID8OR]

TweetThis is the DRUG the ball players are being questioned about ...I saw this on another board the other day i thought i'd share it with this board........


SAN JOSE, Calif. - How do you find something, if you
don't know what you're looking for? That was the
challenge facing Dr. Don H. Catlin, the molecular
pharmacologist at the University of California-Los
Angeles who was handed a near-empty syringe with a few
tiny droplets of a substance suspected to be a new,
undetectable steroid used by some athletes. "It's
tough," he said. "You're looking for something that is
unknown. It's a needle in a haystack. And it could be
nothing." Catlin's lab, the UCLA Olympic Analytical
Laboratory, provides drug testing and research
services to major sport organizations all over the
United States and abroad. One of its specialties is
steroids, banned substances proven to enhance
performance by increasing muscle strength. But the
search to identify the substance in the syringe,
provided to the U.S. Anti-Doping Agency by a track and
field coach who said athletes had found a new steroid,
"was the first time we were ever really taxed to our
limits," he said. Once a syringe is used, tiny
droplets of fluid remain on its walls and plunger.
Catlin's first step was to rinse the remnants of the
mystery substance from the syringe with methanol, a
chemical solvent. Then the substance was screened by a
mass spectrometer, a powerful analytical tool that is
used to identify chemical compounds. Each substance
creates what chemists call its unique "fingerprint" -
actually, an image that resembles a mountain-like
profile of peaks and valleys. The substance from the
syringe yielded a pattern of 20 to 25 peaks that fit
no pattern ever seen before. "It didn't match anything
we'd ever seen," Catlin said. "We had to scratch our
heads and say hmmmmm." So they moved on to other
tests, using different approaches. Over weeks, they
were able to draw, on paper, the molecular structure
of the substance. Its structure strongly suggested
that it was a steroid, not a stimulant. Their interest
continued to grow. "In this business, it's not enough
to be 99 percent sure," said Catlin. "You have to
prove it." The way to prove it was to build the
substance themselves, based on the structure they had
drawn. So they synthesized the chemical in their lab.
Then they took their chemical, ran it through the mass
spectrometer, and compared its fingerprint to that of
the mystery substance. Bingo: A match. "They were
identical. Now we knew what it was," he said. And
"because of its molecular structure, it was clearly an
anabolic steroid," he said. "I know a lot about what
makes a steroid, and there is no question in my mind
that it is - and that it could have beneficial
effects" for performance. Even though the chemical is
structured slightly differently from known steroids,
it is close enough that the human body responds in the
same way, Catlin said. The final challenge for
Catlin's lab was to create a test that would detect it
in athletes' urine. The chemical had eluded detection
because existing tests didn't screen for it. Catlin
mixed his lab-built substance with urine, then created
a way to extract it from the thousands of other
substances in urine. This was the basis of a test that
can detect the substance - called tetrahydrogestrinone
(THG) - based on its characteristic chemical features.
THG is not a "pro-steroid" or "precursor steroid,"
like many other performance-boosting substances on the
market, Catlin said. Rather, "this is a stand-alone
steroid," he said. Whoever created it knew enough
chemistry to make changes that were so subtle they
slipped through the radar, according to Catlin. "It's
just a little different, not dramatically different.
Whoever developed it deliberately tried to make it
hard to find," Catlin said. "That is very clear."

--------------------------------------------------------------------------------
THG

Tetrahydrogestrinone, or THG, is a designer steroid
whose effects are probably similar to related classes
of anabolic steroids. Users become bigger and
stronger, says a leading expert, but it has side
effects: "Men become more ladylike and women more
manlike." Composed of 21 carbon atoms, 28 hydrogen
atoms and two oxygen atoms, each molecule of THG is
shaped "like a pretzel or popcorn," says Dr. Don
Catlin, director of the UCLA Olympic Analytical
Laboratory in Los Angeles. But that little molecule
likely can dramatically alter cell functions in the
bodies of athletes who use it. "THG is a typical
anabolic steroid -- it'll make you bigger and
stronger. "It'll also make hair grow on your face if
you're a woman and make you balder if you're a man,"
Catlin said in a phone interview Thursday. "A man's
testicles will shrink and his breasts will grow, while
a woman's breasts will get smaller. And your blood
chemistry will get out of whack in ways it would take
me a long time to explain." THG is definitely
artificial, meaning that it was created by someone,
somewhere. That's because there's zero evidence it
exists in nature, Catlin explained. Routine tests for
detecting anabolic steroids are "totally blind" to
THG, Catlin said. One of his goals is to find an
easier way to identify it in routine tests of
athletes' urine -- more routine, that is, than his
UCLA team's summer-long investigation into the mystery
drug. This summer, Catlin's team members discovered
THG when they noticed an odd-looking "peak" on a
jagged pattern of 25 "peaks" on a computer printout
from a device called a mass spectrometer. Each peak
represented the spectral "signature" of a particular
organic molecule, one of 25 molecules from a syringe
that a concerned track and field coach sent early this
summer to the U. S. Anti-Doping Agency (USADA), a
nonprofit corporation responsible for drug testing of
U.S. Olympic athletes. "We got the syringe in the
middle of June. It took eight chemists (on our team)
two months to figure out the first step -- namely,
what it was," says Catlin, who has an M.D. from the
University of Rochester and has run the UCLA lab since
1982. After figuring out the molecular structure of
THG, Catlin and his team successfully manufactured
samples in the lab, he said. Typically, steroid
molecules "have a certain (characteristic) structure.
If I were to draw (THG) next to (a picture of)
testosterone on a piece of paper, you'd say, 'Oh yes,
I can see the similarity.' But the details are a
little different." Although others have called it a
"designer steroid," Catlin says he prefers to call it
an NCE or "new chemical entity."

[gearedup]

TweetInteresting I have never heard of this before!

[bob46]

Tweetsome big name track athletes are in big, big trouble...

[Remo]

TweetTHG has anti-e and anti-progesterone properties fro what I know so that Dr is full of shit and just giving negative publicity for the sake of his personal views on steroid use. You can tell by his tone. THG CANNOT cause gyno, period.

[jipped genes]

Tweethe is stereotyping gear by saying that. it shows his ignorance but the general public beleives every work, steroids are evil and so are the people who use them.


i heard the stuff is legal through some loophole about new compounds or something like that is that true.

[Remo]

TweetI wish I knew. I'd love to get my hands on a ORAL trenbleone like substance that won't aggrevate my gyno!

[INTIMID8OR]

Tweethttps://www.nytimes.com/2003/10/19/sp...59&partner=AOL

[INTIMID8OR]

TweetIts funny how two people can read something and come up with completely different views ....In my ipinion this 'DOCTOR " is just giving his view on THG AFTER ALL he's a doctor ....


"A man's
testicles will shrink and his breasts will grow, while
a woman's breasts will get smaller. And your blood
chemistry will get out of whack in ways it would take
me a long time to explain."

This is he's view and you really can't argue his opinion after all it's not he's job to recommend "POST CYCLE THERAPY" Now is it ? lololl

[jack hust]

Tweetthanks intimid8or3 that was a good thread

[INTIMID8OR]

Tweet

Originally posted by jack hust
thanks intimid8or3 that was a good thread

Thanks JH...

[BIG N]

Tweetthat doc is a fuckin tool ,and that trenbolone dirivative ,is pretty much uselass to us,why bother ,we have tren ,its all media hype .

[viper10139]

Tweetdamn good read!!

[josh Dewey]

TweetThat THG is just a weaker version of trenbolone

the benefit of THG is just that they couldn't find any THG in your body.

So THG is more for athletes who have drug tests, than bodybuilders like us.

Tren is way better then THG, that's why we never heard of an bodybuilder using that.

[drab4]

Tweet

Tren is way better then THG

Not trying to be funny, but how do you know that? Used it? Seen studies?

[drab4]

TweetSame goes to others who've said it's no use..... Why are people saying this?

Me personally, I know nothing about it.