Reply With QuoteTweetVery interesting- thanks Mick
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Elite Senior Resident
Effects of tamoxifen on GH and IGF-I levels in acromegaly.
TweetCozzi R, Attanasio R, Oppizzi G, Orlandi P, Giustina A, Lodrini S, Da Re N, Dallabonzana D.
Divisione di Endocrinologia, Ospedale Niguarda, Italy.
Tamoxifen (TAM), a non steroid partially competitive antagonist to the estrogen receptors, has been reported to decrease plasma GH and IGF-I levels both in vitro and in vivo. These data prompted us to evaluate GH and IGF-I changes in acromegaly after acute and chronic TAM administration. Nineteen acromegalic patients (6 M, 13 F, aged 30-70 years) were studied in a prospective open study. Acute TAM test (20 mg po) did not induce any significant change in GH and IGF-I levels. Chronic TAM treatment (20 mg/day for a month and 40 mg/day for another month) induced a transient increase in GH levels (from 9 [3-139] micrograms/l [median, range] to 12 [3-188] micrograms/l, p = 0.0025) and a persistent decrease in IGF-I levels (from 785 [500-1200] micrograms/l to 553 [209-1420] micrograms/l, p = 0.0034). Individual IGF-I values decreased in 13 patients and reached the normal range in 4 of them. At TAM withdrawal hormonal levels increased up to pretreatment values. There was no correlation between GH and IGF-I changes and results were not influenced by age, sex or gonadal status. In this setting it is likely that the observed decrease in plasma IGF-I levels is dependent on TAM activity at the hepatic level.
FG Resident
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
TweetVery interesting- thanks Mick
Established Member
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
Tweeti wasn't really able to tell from the article... this is a temporary decrease in levels right?? I can't imagine it being permenant. That would suck.
I run suicide drills over and over with the weight of the world on my shouders... I'm far from being god, but i work god damn hard.
FG Resident
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
TweetYes- they go back to normal after coming off TAM.
"At TAM withdrawal hormonal levels increased up to pretreatment values."
Established Member
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
TweetAh... tam = tamoxifen i had no idea what "tam withdrawal" was. Makes sense. Thanks broOriginally Posted by geesler
I run suicide drills over and over with the weight of the world on my shouders... I'm far from being god, but i work god damn hard.
FG Resident
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
TweetI read that femara actually increases igf
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Lord, make me strong, and let the weak find comfort in my strength.
FG Resident
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
TweetYes it does, slightly, I have an article on it somewhere if I can find it I'll post it up. Adex, like Tamox also causes a decrease in igf levels
VET
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
Tweetas one of my esteemed bros once said when this topic came up. better slightly decreased igf levels than having to wear a bra
"SHIAT BIOTCH, thats a big ass!"
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Elite FG Resident
Re: Effects of tamoxifen on GH and IGF-I levels in acromegaly.
Tweetacromegaly-
Pronunciation: "a-krO-'me-g&-lE
Function: noun
Etymology: International Scientific Vocabulary
: chronic hyperpituitarism marked by progressive enlargement of hands, feet, and face
These tests were not done on "normal" people.
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