TweetTake 1/3 when you wake up, 1/3 mid day, and 1/3 before bed. Some peole swear by the "take 17-aa's with grapefruit juice on a empty stomach" thing but i have never been able to tell the difference. Some people experience GI distress when taking it on a empty stomach. I don't think it would hurt at all to take it with a SMALL meal