Tweetalso bouncing off of dk's response. dont forget that with cream you are peaking and dropping super super fast. so that in itself is going to cause serious issues in some people. if you absolutely have to go with the topical route then i would ask for a patch or go with an implant. one of the older guys at my gym uses the implant and swears by it. no estro issues or any issues at all except when it is starting to run out.