Animis Cordis

[guns01]

TweetCardiovascular
disorders are currently the leading cause of mortality worldwide.
Maintenance of a healthy cardiovascular system is pivotal to longevity
in addition to keeping a healthy mind and body. Cordis by Animis is the
most potent cardiovascular support formula currently available on the
market. With
the utilization of a synergistic blend of natural herbs formulated in
Cordis, each ingredient potentiates the pharmacokinetic effects of the
other. Making the therapeutic effect of the formula more potent than
that obtained from any individual compound.
Users of this powerful formula will experience a reduction in blood
pressure, lipids, plaque buildup, and improved liver function.

Salviae Miltiorrhizae
Elevated
levels of cholesterol and blood pressure are two major contributors of
atherosclerosis and cardiovascular disease [01]. Salviae Miltiorrhizae
has been used in traditional chinese medicine, for more than a
millennium, for the treatment of blood disorders. Major components of
salviae miltiorrhizae, include salvianolic acid & tanshinoate.
Salvianolic acid B and Tanshinoate II are considered the two active
component known for the management of circulatory disorders [02][03].
Salviae Miltiorrhizae extract has been shown to increase the export of
total cholesterol and bile acid in the liver, while reducing
LDL-cholesterol and increasing HDL-cholesterol in humans [04][05].
Tanshinoate IIA is one of the many active components responsible for
lowering LDL, threw its ability to inhibit LDL oxidation [06][07][08].
Tanshinoate also acts to upregulate superoxide dismutase activity and
eNOS phosphorylation, making it a powerful antioxidant and increaser of
NO production [09][10]. Tanshinone IIA is a potent cardioprotective
compound, that is able to regulate various transcription factors, ion
channels, kinases, growth factor, inflammatory mediators, and more [11].
Acting to limit hypertrophy, improve heart function and strength by
decreasing oxidative stress [12][14][13][15].

Salvianolic
acid B protective therapeutic effects are due to its ability to act as a
potent antioxidant/reactive oxygen species, anti-fibrotic agent, and an
inhibitor of inflammation. Additionally, Salvianolic acid B is able to
act as inhibitor of ACE, reducing the conversion of angiotensin I to
angiotensin II and lowering blood pressure [16]. Tanshinoate IIA like
Salvianolic acid B is able to indirectly reduce the production of
angiotensin II. In addition Tanshinoate IIA is able to reduce the
accumulation of cholesterol by macrophages, vary smooth muscle migration
and proliferation. As well as reduce the ratio of thromboxane b2 to
6-keto prostaglandin f1α, leading to an improvement in our blood
coagulation system [17]. As a side note Tanshinoate IIA has also been
found to act as a powerful anti-cancer by its ability to trigger
apoptosis through P53 activation among other mechanisms [18][19].
Additionally it has been shown to improve renal dysfunction by its
interaction with angiotensin II, transforming growth factor β1 and
collagen IV, as well as inducing apoptosis of hepatic stellate cells,
reducing the effects of liver fibrosis, in rats [20][21]. Overall
Tanshinone II is seen to be a very potent natural cardioprotective with
its ability to dilate coronary arteries, lower blood pressure and
lipids, protect from ischemic injury, act as a anti-inflammatory,
antiplatelet, antithrombotic, antiarrhythmic, anticoagulant, and reverse
myocardial hypertrophy [22][23][24][25][26].

Panax notoginseng
Ginseng
is widely known for it restorative and healing properties. Panax
Notoginseng has specifically been shown to have protective effects
against cardiovascular disease, liver fibrosis and hepatotoxicity
[27][28][29]. Primarily through the effects of its various constituents
that have been shown to provide antioxidation, decreased platelet
adhesion, vasomotor control and improved lipid profiles. Additionally it
has been shown to enhance physical performance during endurance
activity in humans [30]. This is primarily due to high levels of radical
scavenging antioxidants and saponins that exhibit anti-inflammatory,
vasodilating, anti-fatigue and the ability to act as a central nervous
system stimulant [31][32]. Panax notoginseng may also be able to provide
cardiovascular protection through various pharmacological mechanisms
that improve microcirculation, regulate lipids, reducing arrhythmia, and
has been shown to normalize blood pressure by restoring it to normal
levels in individuals with both high and low blood pressure
[33][34][35]. It has also shown to act as an antioxidant against
atherogenesis [36]. For spanions of Panax Notoginseng have been found to
have antihyperlipidemic and atherosclerotic effects [37][38][39][40].
These atherosclerotic effects are especially prominent when used in
conjunction with Salvia Miltiorrhiza [41]. Additionally It has also been
shown to be beneficial in protecting against tissue damage, have
antihypertensive effects and may be a novel therapy for heart failure,
as well as acting as a powerful antioxidant by its ability to
significantly increase both superoxide dismutase and glutathione
peroxidase activity [43][44][45][46]. By protecting cardiac muscle from
ischemic and reperfusion injuries [47]. Research has also shown
notoginseng to inhibit platelet aggregation and have preventive effects
for thrombosis in vivo [48][49][50].

Pueraria Lobata
Pueraria
Lobata has been used in conjunction with Salviae miltiorrhizae
traditionally. Studies have shown that the two herbs work
synergistically and additively, leading to improved vascular function in
coronary patients [51][52][53]. Studies have demonstrated it to have
anti-hypertension, anti-thrombosis, cholesterol lowering effects, and
when used in conjunction with Salvia Miltiorrhiza is able to lower
low-density lipoprotein and total cholesterol levels in human subjects
[54][55][56][57][58]. Additionally, Puerinin has been shown to have
protective effects against liver fibrosis, providing reduced oxidation,
inflammation, of the liver, as well as protective effects against liver
fibrosis and blood pressure [59][60][61][62].

Natural Borneol
Natural
Borneol is utilized to increase the pharmacokinetic effects of the
formula, particullary offering a significant 1.3-1.6 fold increase in
effects of the saponins of notoginseng, as well as increasing the
intestinal absorption and effects of the constituents of Salvia
Miltiorrhiza [63][64][65]. In addition it helps improve oral
bioavailability for the entire herbal formula [66].


[01] Beckerman, J. (2014, May 26).
Atherosclerosis: Causes, Symptoms, Tests, and Treatment - WebMD.
Retrieved November 19, 2014, from https://www.webmd.com/heart-disease/w...therosclerosis

[02] Lam, F.F., Yeung, J.H., Kwan, Y.W., Chan, K.M., Or, P.M., 2006.
Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary
artery by inhibition of calcium channels.
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[03] Chan, P., Liu, I.M., Li, Y.X., Yu, W.J., Cheng, J.T., 2009.
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[04] Zuchang Li, Ling Zhu, Bin Huang.
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[17] Journal of Geriatric Cardiology March 2009 Vol 6 No 2

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[19]Yong Zhang 1, Peixin Jiang 1, Min Ye 2, Sung-Hoon Kim 3, Cheng Jiang 1,* and Junxuan Lü
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[21] X.H. Che, E.J. Park, Y.Z. Zhao, W.H. Kim, D.H. Sohn
Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells
Basic Clin. Pharmacol. Toxicol., 106 (2010), pp. 30–37

[22] M. T. Zhang, Y. H. Qian, and A. Q. Tang,
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[31] Chang Ho Lee , Jong-Hoon Kim
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[32] Q.F. Xu, X.L. Fang, D.F. Chen
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[34] Shin W, Yoon J, Oh GT, Ryoo S.
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[36] P. Chan, G. N. Thomas, and B. Tomlinson
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[37] Zhang YG, Zhang HG, Zhang GY, Fan JS, Li XH, Liu YH, Li SH, Lian XM, Tang Z.
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[38] Liu G, Wang B, Zhang J, Jiang H, Liu F.
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[39] Jia Y, Li ZY, Zhang HG, Li HB, Liu Y, Li XH.
Panax notoginseng saponins decrease cholesterol ester via up-regulating ATP-binding cassette transporter A1 in foam cells.
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[40] Kwak YS, Kyung JS, Kim JS, Cho JY, Rhee MH.
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[49] Dong-Ha Lee DH, Cho HJ, Kim HH, Rhee MH, Ryu JH, Park JH.
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[guns01]

Tweetanother addition to my supp lineup recently.

after doing a little brain storming with tgb we decided to add this in to my preventive supps. i have been using cycle support 2.0 for a long time now. i sent a message over to tgb about their thoughts on me keeping it in or switching things up for a bit and this was the recommendation. i have been taking it for about a few days now. i completed my 7 day 4-way cleanse before i started this product up though. now usually when i add in a new supp sometimes i get stomach issues or it takes time for me to adjust to them. i have had no issues with my guts so far. now if you dont get the caps down all the way the after taste is pretty nasty haha. i had that happen once but no biggie. cardio protection is very important for what we do and this is another great addition to my lineup

[BABY1]

TweetSounds like an excellent product. thanks for the feedback so far, guns

[BABY1]

Tweethttps://www.tgbsupplements.com/p-159...is-cordis.aspx

[gusto77]

TweetI'm jumping on this. Just tried to order some but they are out of stock. Any ideas when more is coming in TGB? There are a few other things I wanted to order as well but wanted to get them altogether to lessen shipping costs. Phenomenol product line TGB!

[6p6]

Tweet

I'm jumping on this. Just tried to order some but they are out of stock. Any ideas when more is coming in TGB? There are a few other things I wanted to order as well but wanted to get them altogether to lessen shipping costs. Phenomenol product line TGB!

Bump


Sent from my iPhone using Tapatalk

[slin 2 win]

Tweet2 bottles available bud. back in stock

[gusto77]

TweetGot em! Thanks!