Glycøshield represents the pinnacle of a multi purpose weight management & nutrient partitioning product. Not only is Glycøshield a clinically dosed nutrient partitioner & glucose disposal agent, it also includes clinically studied and trademarked ingredients that have been shown in studies to boost metabolism, prevent excess fat gain & blood sugar spikes, prevent & reverse type 2 diabetes, lower bad cholesterol, act as an anti inflammatory & more.
*Combine with HPS Lipøshield for additional metabolic support, calorie control, and weight management
Glycøshield combines powerful ingredients that set off three-way Glut-4 activation and allow you to exploit the coveted post- workout “anabolic window” at all hours of the day. Concurrent minimization of adipose creation, improved lipid profiles, lowered prandial and post-prandial blood glucose levels, and PPARγ activation will turn you into a human fat burning machine.
These unparalleled capacities make Glycøshield highly versatile. Whether you’re a bodybuilder striving for that perfect physique, an athlete aiming to improve performance, or one of the 25+ percent of Americans who battle metabolic syndrome, Glycøshield will has a place in your health, fitness, and wellness regimen.
Gain lean muscle and lose fat. At the same time. Dream no more.
BUILD MUSCLE- Glycøshield amplifies lean muscle mass by increasing insulin sensitivity, amino acid uptake, glycogen super-compensation, and creating utilization. It will enhance your strength, endurance, and pump.
LOSE FAT- Glycøshield prevents fatty acid synthesis, lowers prandial and post-prandial blood glucose levels, and speeds up fat oxidation rates. It will also block glucose and triglyceride uptake in fat cells.
Regardless of your age, sex, or goal, everyone can benefit from the opportunity to improve lipid levels, glucose levels, and body fat levels, as well as reduce risk of cardiovascular diseases by obstructing LDL particles (“bad cholesterol”) before they attach to arterial walls.
Beyond its suitability as a sports nutrition supplement, Glycøshield can also be utilized by Type 2 diabetics as an adjunct or alternative to oral hypoglycemics. Anti-hyperglycemic agents, such as Metaformin, help diminish insulin resistance by lowering hepatic glucose production and sensitizing tissues at the cellular level to uptake glucose. Unfortunately, use of these oral hypoglycemics typically cause individuals to gain additional adipose tissue, only perpetuating diabetic health complications. Ingredients in the GLYCØSHIELD COMPLEX, however, have been shown to act similarly to these oral medications in offsetting progressive insulin resistance while simultaneously limiting fat gain, dyslipidemia, and subsequent obesity.
Human Performance Science is dedicated to sourcing only the most effective, highest quality ingredients available for our products. Glycøshield uses a synergistic combination of nothing but the full doses applied in clinical trials and studies. No marketing flash to cover up substandard results, no hiding behind labels that read “Highly Standardized”, “Specialized Extract”, or omit active percentages entirely. HPScience is proud to stand by our products.
Garcinia Cambogia 50% HCA (Hydroxycitric Acid) can block fat production by 45-70% for up to twelve hours after a meal . HCA supresses Citrate Lyase and subsequent formation of Malonyl Coenzyme A – the foundational “building blocks” of fat cells. In turn, a low concentration of Malonyl Coenzyme A increases fat oxidation in both adipose and liver tissue . Additionally, HCA promotes ketone production and slows muscle tissue breakdown in a hypocaloric environment. Because greater lean mass creates a faster metabolic rate, this equates to less stringent calorie restriction in periods of dieting . Perhaps most promisingly, no immediate visceral fat regain or “rebound effect” is noted after ceased usage of HCA .
Berberine HCL has demonstrated capacity to lower fasted and postprandial blood glucose levels via Glut-4 translocation and insulin receptor expression increase [3, 4]. A recent medical study concluded that Berberine is as potent as Metformin – better known as “Glucophage” – with regards to control of insulin/glucose levels and lipid parameters. The study noted cumulative decrease in participant body weight attributable to Berberine’s influence on insulin sensitivity and fat distribution. Weight-loss outcome may have resulted via up-regulation of the LDL-c receptor and reduction of total LDL-c or through differentiated adipocyte inhibition in the PPARγpathway [4, 5]. Berberine, as compared to Metformin and Acarbose, exhibited that “insulin sensitivity was enhanced by berberine as the HOMA-IR value was reduced by nearly 50%. This effect may be related to fat distribution by berberine because waist and waist/hip circumference of the patients were decreased significantly in the absence of weight change. Interestingly, both fasting and postprandial C-peptides increased significantly in patients when berberine was used together with insulin, which suggests that long-term berberine treatment may improve insulin secretion of the patients with consequent failure of oral hypoglycemic agents.” The GLYCØSHIELD COMPLEX – which offers a synthetic compound extract derived from the plant – protects against inconsistent/varied extract concentration and acute gastric upset, two problems commonly encountered with other Berberine-based nutrient partitioners.
Salaretin®️ Salacia Reticulata Extract contains the active compounds Mangiferin, Kotalanol, and Salacinol that act as a PPARα agonist and PPARγ partial agonists; these thwart postprandial hyperlipidemia, hyperglycemia, and hepatic steatosis in type 2 diabetics and obese subjects [6, 7]. PPARα, located in skeletal muscle and liver tissue, is responsible for transport/usage of fatty acids to fuel bodily processes. By down-regulating apolipoprotein C-III, PPARα inhibits lipid hydrolysis and boosts lipid oxidation. Somewhat similarly, PPARγmediates the genes responsible fasted regulation of beta/gamma oxidation, and amplified fat oxidation. Mangiferinelevates Glut-4 without exercise and supports rapid muscular glycogen uptake.
GS4 PLUS®️ Gymnema Sylvestre 75% Gymnemic Acids is clinically proven to dramatically lower HbA1c, fasting blood glucose, and postprandial glucose levels . Gymnema speeds glucose transfer from the bloodstream into muscle tissue. A year-long Indian study demonstrated that daily Gymnema consumption led to a notable drop in HbA1c and decrease from 232 mg/dL to 152 mg/dL in fasted blood glucose levels . Gymnema can, furthermore, regenerate and multiply the quantity of insulin secreting beta cells in the pancreas, enabling those with poor insulin sensitivity to improve natural bodily insulin output .
Banaba Leaf 10% Corosolic Acid is sourced from Banaba, an Asian tree leaf employed in various forms to treat diabetes and kidney-related diseases. Corosolic Acid restrains preadipocytes from developing into mature fat cells. It also augments insulin-independent glucose uptake through Glut-4 translocation, thus requiring lesser amounts of insulin to shuttle glucose into cells . Statistically significant decreases in 60-120 minute post-prandial insulin levels with Corosolic Acid supplementation have been discovered in medical experimentation . Additionally, Corosolic Acid has been shown to block gluconeogenesis and increase glycolysis . GLYCØSHIELD contains the strongest Corosolic Acid extract available today and is dosed at the clinically studied amount.
Olive leaf extract (OLE 20% oleuropein) has a variety of health benefits as well as the ability to keep the fat off of you. OLE has been shown to increase beta cell responsiveness by 28% and insulin sensitivity by 15% (14). Why is this important?
As we age, our diabetic beta cell function declines and our insulin sensitivity begins to diminish. Supplementing with OLE can greatly improve the numbers for those of you looking to reduce your AIC and fasting glucose levels. OLE has also been shown to Reduce PPARy transcription which is a known factor in adipogenesis (15)(16). With that said, we look at the effect it has on T3, a thyroid regulating hormone(17). Supplementation with 20% oleuropein demonstrated effects on the enzyme 5'-deiodinase. This enzyme converts the less active thyroid hormone T4 into the more active T3 in the body.
In rats that were given 500 micrograms of Olive Leaf Extract, the concentration of the T3 rose by a factor of 2.5. This change is significant for those who are looking to lose fat quickly.(17) l
In regards to blood sugar, a 2012 study showed that OLE was able to decrease HBa1C and fasting insulin levels. However post meal levels did not change suggesting a inhibition of carbohydrate digestion. This is why OLE has been included in our Glycøshield Complex.
Other improved health markers for OLE include Increased LDL oxidation (18) increased HDL and lower blood pressure (19)(20)(21). OLE may also reduce inflammation through a pathway known as MCP1 which has been implicated in joint inflammation in rhumatoid arthritis and kidney inflammation shown in lupus. MCP1 is also high in those with Alcohol induced liver injury (23). OLE is overall an ingredient that will help keep you lean AND improve key health markers, especially as we age.
1] Sherwin RS et al.; Journal of Clinical Invest.;1975 55:1382-1390
 Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.; Kohsuke Hayamizu MS et al.; Current Therapeutic Research.; Volume 64, Issue 8, September-October 2003, Pages 551-567
 Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.; .Zhang H et al.; Metabolism. 2010 Feb;59(2):285-92. Epub 2009 Oct 1
 Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.; Zhang, Y et al .; The Journal of Clinical Endocrinology & Metabolism, 93(7), 2559- 2565.
 Efficacy of berberine in patients with type 2 diabetes mellitus.; Yin, J., Xing, H., & Ye, J.; Metabolism Clinical and Experimental, 57(5), 712-717 (2008)
 Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin.; Girón MD et al.; Clin Nutr. 2009 Oct;28(5):565-74. Epub 2009 May 23
 Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in zucker diabetic fatty rats: activation of PPAR-Alpha.; Huang TH et al.; Toxicology Applied Pharmacol. 2006 Feb 1;210(3):225-35. Epub 2005 Jun 21
 The effect of extended release Gymnema sylvestre leaf extract alone or in combination with oral hypoglycemics or insulin regimens for type 1 and type 2 diabetes.; Joffe, D.J. and S.H. Freed Diabetes in Control Newsletter, 76(1) 2001
 Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus.; Shanmugasundaram ER et al.; J Ethnopharmacol. 30(3):281-94.
 Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts.; Shanmugasundaram ER et al.; J Ethnopharmacol. 30(3):265- 79.
 An Extract of Lagerstroemia speciosa L. Has Insulin-Like Glucose Uptake-Stimulatory and Adipocyte Differentiation- Inhibitory Activities in 3T3-L1 cells.; Journal of Nutrition, 131, 2242- 2247
12] Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.; Shi, L et al.; European Journal of Pharmacology, 584(1), 21-29
 Effect of Corosolic Acid on gluconeogenesis in rat liver.; Yamada k, Hosokawa M, Fujimoto S et al.; Diabetes Research and Clinical Pract. 2008 Apr;80(1):48-55. Epub 2008 Jan 4.
14. Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial
15. Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells
16. Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis
17. Effect of freeze dried extract of Olea europaea on the pituitary–thyroid axis in rats
18. Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats
19. Antioxidant Effect Of Virgin Olive Oil In Patients With Stable Coronary Heart Disease: A Randomized, Crossover, Controlled, Clinical Trial
20. Olive Oils High In Phenolic Compounds Modulate Oxidative/antioxidative Status In Men
21. Olive (Olea Europaea L.) Leaf Polyphenols Improve Insulin Sensitivity In Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial
22.Protection Of LDL From Oxidation By Olive Oil Polyphenols Is Associated With A Downregulation Of CD40-ligand Expression And Its Downstream Products In Vivo In Humans
23. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice.