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Lipøshield is an extremely versatile product designed to help you burn fat AND prevent the accumulation of new fat cells. Lipøshield is a caffeine and stimulant free flavorless powder with no fillers that can be added to seasoned meals or batters to help block the absorption & accumulation of fat & excess calories which makes Lipøshield the perfect supplement for cheat days, cheat meals, & refeeds. Lipøshield can be used daily to assist with your weight loss/management & fat burning goals year round. Just add Lipøshield to your favorite pre workout, protein, amino powder, or any other beverage to instantly turn it into a fat burning powerhouse. Lipøshield is safe for both men & women and can be used daily to maximize fat loss & weight management.

HPScience is proud to introduce Lipøshield.

Unlike other other products and ingredients that are supposed to be “fat blockers” or wasting agents, none have been clinically dosed to be truly effective.

HPS has combined two novel yet synergistic ingredients to create an product that will help shift your metabolism and increase both caloric wasting (energy expenditure) and fat oxidation properties (your ability to burn and block fat).

The combination of Lipøshield and Glycøshield (The Shielded Stack) will set the a bench mark for fat loss and health benefits related to proper blood sugar control, cholesterol control, thyroid support, and weight management.

Learn more about the two powerful ingredients found in Lipøshield:

Garcinia Cambogia (Fruit) (Hydroxycitric Acid)

A potent plant derivative with clinically proven lipid metabolism/oxidation potential [2]. Via inhibition of Malonyl Coenzyme A, the so called “building blocks” of fat, HCA blocks adipose production for upward of twelve hours after a meal [3,4]. As HCA stops creation of new fat cells, it simultaneously prompts adipose and liver tissue to oxidize bodily fat stores. By slowing gastric emptying, HCA lowers post prandial glucose response [5].

In layman’s terms, HCA has been clinically proven to block the production of fat cells for to 12 hours following a meal while at the same time helps your body more rapidly and easily tap into fat stores for energy (burning stored body fat as fuel!) HCA was also shown to prevent blood sugar spike following meals.

Clinical supplementation (the amount use in Lipøshield) with Garcinia Cambogia led to, “significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group”, and, moreover, no visceral fat regain after cessation of use [6]. Beyond this, in a hypocaloric environment – created when one begins to diet – HCA will also help limit muscular catabolism and breakdown [4].

What does this mean?

In a study the the group who used Garcinia Combogia (HCA) showed reductions in body fat over the group who received a placebo, and Fat was not gained back once they stopped using the ingredient. Additionally, for those who may be dieting and eating reducing calories, HCA has been shown to help prevent the breakdown and loss of muscle tissue.

Not only does HCA help prevent fat gain, it also increases fatty acid oxidation and expression of GLUT-4 protein and glycogen supercompensation during physical activity [7,8].

Studies on HCA have shown data that has displayed super-compensation of glycogen during physical exercise with increased fatty acid oxidation, as well as showing increased expression of CD36 in the presence of a high carbohydrate meal demonstrating that there is an increase in fatty acid oxidation even while continuing to eat carbohydrates [14]. This means that Lipøshield fits perfectly for those who want to remain in the elusive fat burning zone after a high glycemic post workout carbohydrate meal and is why we have included it in our GDA and nutrient partitioning product Glycøshield.


Raspberry Ketones:

Yes, the ingredient made popular by Dr. Oz. The only problem with many RK products on the market is that you simply aren’t getting a large enough amount for them to be effective. HPS is all about proper, clinical dosing for our products to ensure efficacy for our customers. Raspberry Ketones are similar in structure to synephrine and capsaicin, which are both noted as being thermogenic due to their release of norepinephrine and increase in Hormone-Sensitive Lipase (HSL). The dietary administration of Raspberry Ketone has been used to prevent high-fat diet-induced elevation in body weight while also showing anti-obesity effects [9] and to increase lipolysis in white adipocytes and increase lipolysis significantly in differentiated 3T3-L1 cells [10].


Raspberry Ketone prevents and improves obesity and fatty liver through the measurement of the RK’s eroxisome proliferator-activated receptor (PPAR)-α activity [11]. These effects appear to stem from the action of RK in altering the lipid metabolism, or more specifically, in increasing norepinephrine-induced lipolysis in white adipocytes [10]. Not only has RK’s proved to aid fat oxidation and HSL but have also been linked to the reduction of inflammation by inhbiting LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway [12].

Rapsberry Ketone have been tested both in vivo and in vitro and have inhibited melanogenesis (the formation of melanoma) through a post-transcriptional regulation of tyrosinase gene expression, which resulted in down regulation of both cellular tyrosinase activity and the amount of tyrosinase protein [13].

Further to the ability to increase fatty acid oxidation, RK’s have the ability to expand the post workout thermogenic window by more than 30 minutes from the latter stages of exercise [15].

Another action that RK’s have shown promises in is their ability to mediate long term stress and depression through the potent TRPV1 channel activator which may have a role in long-term changes in physiological and pathological circuit behaviour during learning and epileptic activity [16,17].

We all know that the fatty liver and visceral fat are a big problem when trying to maintain homeostasis and all phases of our physique goals, but we need to understand that Intraheptic fat takes the cake for the worst fat. Whether bulking, cutting or recomping, the metabolic problems associated with intraheptic fat, visceral fat, and fatty liver can be minimised through the use of RK’s which will help alter the fatty acid uptake and redirect plasma fatty acids from adipose tissue to other tissue [18] promoting greater health benefits.

The combination of ingredients found in Lipøshield and Glycøshield synergistically work to produce dramatic changes in body composition; less fat, more muscle, optimal health and performance.

References:

[1] Pedersen SB, Kristensen K, Hermann PA, Katzenellenbogen JA, Richelsen B. (2004), Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J Clin Endocrinol Metab. 2004 Apr;89(4):1869-78.

[2] Shara M, Ohia SE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ, (2003), Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem. Dec;254(1-2):339-46.

[3] Sherwin RS et al. ; Journal of Clinical Invest.; 1975 55:1382-1390

[4] Triscari J, Sullivan AC, (1977), Comparative effects of (--)-hydroxycitrate and (+)-allo- hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo, Lipids. Apr;12(4):357-63.
[5] AM J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1144-9

[6] Effects of Garcinia cambogia (Hydroxycitric Acid) on Visceral Fat Accumulation: A Double-Blind, Randomized, Placebo-Controlled Trial, Kohsuke Hayamizu et al. ; Current Therapeutic Research. ; Volume 64, Issue 8, September – October 2003, Pages 551 - 567

[7] Effects of acute (−)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans, Luc JC van Loon et al.; The American Journal of Clinical Nutrition ;2000.

[8] Cheng IS et al. Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle. Br J Nutr. 2012 Apr;107(7):1048-55. doi: 10.1017/S0007114511003862. Epub 2011 Aug 9

[9] Morimoto C et al. Anti-obese action of raspberry ketone, Life Sci. 2005 May 27;77(2):194-204. Epub 2005 Feb 25.

[10] Park KS. (2010). Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Medica. 76(15), 1654-8.

[11] Wang L et. al, Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. (2012); May;15(5):495-503. doi: 10.1089/jmf.2011.1717.

[12] Jeong JB, Jeong HJ, Rheosmin, a naturally occurring phenolic compound inhibits LPS- induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway, Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2148-53. doi: 10.1016/j.fct.2010.05.020. Epub 2010 May 15.

[13] Chia-Hsiang Victor Lin et al., Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale; 2011 July 28. doi: 10.3390/ijms12084819

[14] A Novel Function for Fatty Acid Translocase (FAT)/CD36, (2004); Campbell et al ,The Journal of Biological Chemistry, DOI 10.1074/jbc.M400566200.

[15] Raspberry Ketones, Starkie Sowers CN

[16] Starowicz K, Cristino L, Di Marzo V. TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications. pharmaceutical design.
2008;14(1):42-54.

[17] Gibson HE, Edwards JG, Page RS, Van Hook MJ, Kauer JA. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. [Internet]. Neuron. 2008 ;57(5):746-59.

[18] Fabbrini E, Magkos F, Mohammed BS, Pietka T, Abumrad NA, Patterson BW, et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. [Internet]. Proceedings of the National Academy of Sciences of the United States of America. 2009 ;106(36):15430-5.

[19] Lopez et al., Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women, (2013); Journal of the International Society of Sports Nutrition 2013, 10:22 doi:10.1186/1550-2783-10-22.