There is no solid evidence that using so-called cortisol blockers such as CortiSlim, CortiStress and Cortistat-PS leads to weight loss.
Manufacturers of cortisol blockers claim that high stress levels increase your body's production of the hormone cortisol, which in turns makes you accumulate excess fat. What they don't say is that the connection between stress hormones and weight gain is still a theory, with only a few preliminary studies supporting it. More important, there's no evidence that blocking cortisol results in weight loss.
Indeed in 2007, the Federal Trade Commission charged the marketers of CortiSlim and CortiStress with making false and unsubstantiated claims about their products' effectiveness for weight loss. As part of the resulting settlement, the companies were forced to pay millions of dollars in refunds and to stop making unproven claims about their products.
Bottom line: The most effective way to lose weight is to control calorie intake and increase the number of calories burned through activity and exercise. There's no magic diet pill that can take off the pounds for you.