Interesting short study on IGF-1 LR3

[TestRip7]

TweetSystemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats.
Medscape Newsletters

Sign Up To Receive
Medscape Best Evidence
Key journal articles ranked for newsworthiness and clinical relevance in each specialty, linked to Medline abstracts.
Am J Physiol. 1997; 272(3 Pt 1):G522-33 (ISSN: 0002-9513)
Steeb CB; Shoubridge CA; Tivey DR; Read LC
Child Health Research Institute and Cooperative Research Center for Tissue Growth and Repair, North Adelaide, South Australia.

This study describes developmental changes in gastrointestinal response to insulin-like growth factor I (IGF-I) peptide administration. Neonatal rats were infused with IGF-I or long [Arg3]IGF-I (LR(3)IGF-I) for 6.5 days starting on day 6 or 12 postpartum. Peptides were delivered by mini osmotic pumps at 0, 2, 5, or 12.5 microg x g(-1) x day(-1). IGF-I infusion increased plasma IGF-I levels in both age groups but stimulated body weight gain only in the older rats. Infusion of LR(3)IGF-I did not change plasma IGF-I levels. Both peptides enhanced expression of IGF-binding proteins (IGFBP) 1 and 2 and induced IGFBP-3 in the older rats. For both age groups, weights of the kidney and spleen increased by up to 85 and 76%, respectively. IGF-I treatment also stimulated gut weight and length by up to 60 and 32%, respectively, but dose dependency was observed only in the older rats. LR(3)IGF-I was more potent for all growth parameters in both age groups. Histological observations included thickening of the mucosa and muscularis externa after infusion of IGF-I peptides. Thymidine labeling in the younger rats indicated that proliferative activity increased proportionately with crypt cell growth. These results show that IGF-I peptides selectively stimulate growth of gastrointestinal tissues in suckling rats and that the proximal gut was the most peptide-responsive region.

Subject Headings

[mr.nitro]

Tweetis that saying that igf-1 gives rats growth gut?

[TestRip7]

Tweet

is that saying that igf-1 gives rats growth gut?

Thats the take that I got out of it.