Scientists find the body produces Cannainoids naturally!!!!!!

[Equalizer]

TweetIt's called 2-AG. It's a cannabinoid, which is a marijuana-like compound produced naturally by the human body. We're all making it, and it kicks in when we need it most - right after a major trauma. Scientists have long known that the body can create a natural analgesic reaction in response to severe trauma. And it is this naturally produced cannabinoid that they plan to use in circumventing anti-marijuana laws in order to bring pain relief to patients.

Source: University Of Georgia

Date: 2005-07-01



Body's Own Marijuana-like Compounds Are Crucial For Stress-induced Pain Relief
Athens, Ga. -- A new study shows, for the first time, that the release of the body's own marijuana-like compounds is crucial to stress-induced analgesia -- the body's way of initially shielding pain after a serious injury.



UGA researcher Andrea Hohmann. (Image courtesy of University Of Georgia)


The work, led by scientists at the University of Georgia and the University of California, Irvine, may yield a target for new drug therapies that will completely bypass the current arguments over the use of medical marijuana. In theory, the new research makes it possible to design a pill that will have the same pain relieving effects as smoked marijuana, but through an indirect mechanism that could also reduce unwanted psychoactive side effects and not have the same political baggage.

"There is no prescription or over the counter drug that allows us to manipulate the level of the brain's marijuana-like compounds," said Andrea Hohmann, a neuroscientist in the department of psychology at the University of Georgia and co-author of the paper. "This is the first time anyone has shown that one of the body's naturally occurring cannabinoids, a compound known as 2-AG, has anything to do with pain regulation under natural conditions."

The study was published today in the journal Nature.

Hohmann's co-author, Daniele Piomelli at the University of California-Irvine, is the discoverer of a compound that blocks the breakdown of this marijuana-like compound called 2-AG, and it is that blocking compound, patented by UC-Irvine, that could become the new drug of choice for those suffering from pain or stress conditions. Importantly, it would not require people to smoke marijuana to obtain relief or wrestle with the legal issues surrounding the drug.

Others from UGA involved in the study include faculty members Philip Holmes and Jonathon Crystal and students Richard Suplita, Nathan Bolton and Mark Neely.

Authors from UC-Irvine include Darren Fegley and Regina Mangieri, in addition to Piomelli. Other co-authors are Jocelyn Krey and Michael Walker from Brown University; Andrea Duranti, Giorgio Tarzia and Andrea Tontini from the University of Urbino Carlo Bo in Italy; and Marco Mor from the University of Parma, also in Italy. All were crucial in designing and synthesizing the enzyme inhibitor.

Scientists have long known that injured athletes or even gunshot victims have a period of time in which the body's pain reaction is delayed. This effect is called "stress-induced analgesia." By the mid-1990s, researchers had targeted the sites of action of the brain's naturally occurring marijuana-like compounds as having a crucial role in blocking pain, but no one understood the conditions in which these compounds were released to block pain.

Researchers along the way found out there are two kinds of stress-induced analgesia mechanisms, opioid and nonopioid (or "opioid independent"). Hohmann and colleagues discovered that the opioid-independent form was produced by release of the brain's own marijuana-like compounds.

"We showed that cannabinoid receptors were involved in this remarkable phenomenon," said Hohmann, "because blocking the receptors where marijuana acts virtually erased this opioid-independent form of stress analgesia."

If this is true, was there a compound that could also prolong the action of these compounds, making them work better? The answer lay in Piomelli's pioneering work on inhibitors that break down the brain's own marijuana-like compounds.

"If we design chemicals that tweak the levels of these transmitter substances in the brain," said Piomelli, "we might be able to boost their normal effects."

When rats used in Hohmann's study were given the compound developed by Piomelli and his collaborators at the University of Urbino Carlo Bo and the University of Parma, it increased stress-induced analgesia dramatically, proving the connection between pain suppression and the release of these marijuana-like compounds.

The enzyme that inhibits the formation of the naturally occurring marijuana-like compound 2-AG is called monoacylglycerol lipase, and it is this enzyme that could be a target for therapeutic drug intervention to help those in pain.

A new drug increasing the body's own marijuana-like compounds could work similar to something like Prozac, which blocks the body's reuptake of the compound serotonin, causing it to be active longer, Hohmann said.

Apparently, several parts of the brain are involved in the effect, most notably a structure in the midbrain known as the periaqueductal gray. In this region, stress causes the release of the naturally occurring marijuana-like compounds in the brain.

A drug derived from the new research would likely be more effective and specific than smoked marijuana, said Hohmann

[kite]

Tweetfuckin pothead

[Equalizer]

Tweetwhat? lol it was on sciencetoday, i wasnt seeking it out i just found it interesting. Being a pothead is better then being a pill popping junkie like 1/3 of america or more. Hey i cant deal with reality eat some pills, hey my big toe hurts eat some pills, hey i eat like shit and have high cholesterol eat some pills.....i really hope you were fucking with me and werent being sincere in your remark because i can go on for days about this shit. A pothead is someone whos world revolve around smoking pot not someone who gets their shit done and then does in their own leisure time but "whatever dude" lol.

[kite]

TweetYou're kinda testy for a pothead. Just kidding, nothing wrong with a little bud after business is taken care of.

[Equalizer]

Tweet LOL. didnt mean to go off but thats one of my buttons that i dont like being pushed and you are correct with your last statement.

[Equalizer]

Tweetmy ex used to use my leisure activities as an excuse for her to be a fucking ***** from hell so i guess it goes back to that. Thats what happens when u are finally honest with a chick about everything, they just use it to throw back in your face when they have nothing else to ***** about. Ive found this true with more then a couple females.

[geesler]

Tweet^^ yep thats right too many times.

Interesting info EQ

[Equalizer]

Tweetthis is relatively new research or at least the findings are just now being released....many times when someone goes into what we call "shock" they dont feel the pain of an obviously serious injury it is because the brain kicks in with its own defense mechanism to protect you so you can cope, shock really doesnt describe it accurately because you are able to cope and deal with what is going on because your body has relieved you of the pain, ive always found the term "shock" as a dumb ass way to describe what is going on because shock to me is if you are unable to think clearly and are not in touch with your surroundings and just being in a frantic state. The body is truely amazing once you began to study it and have an open mind and dont go by what self interest organazation tells you, the body is a complex system and even with as much as we do know we have only began to touch on its abilities and self preservation.