Tweet
Researchers have found in lab mice recently that there is a way to rev up the metabolic machinery that has been pissing us off for centuries. They main goal -- using gentics intead of the gym.
The key protein involved is a protein that has been idetified as PPAR-delta. It was noted to be involved in the break down of fat. Experiments also showed that activating PPAR-delta raised metabolism and helped the mice burn more fat.
Of course now they wanted to know if it would cause them to burn excess fat. So they did what any normal person would do and genetically engineered the mice to produce extra PPAR-delta within their muscle. When the mice were then put on a high-fat, high caloric diet for 13 weeks, the PPAR-delta mice gained only a third of the weight that their unmodified friends did. Heres the big deal: The mice on this diet remained resistant to obesity even when they were kept inactive.
"Although Evans (the biochemist responsable) recognizes the potential for abuse by athletes, he believes that his work has more practical implications in treating metabolic ailments, including obesity and heart disease. Patients with such conditions often cannot exercise because of their weight or other complicating problems. "This work could lead to an exercise pill that gives many of the benefits of training without the need to sweat," Evans predicts. Indeed, in a separate experiment he gave normal mice a drug called GW501516, which activates PPAR-delta directly. The drug caused many of the same changes in muscle and metabolism as those in the transgenic mice, including protection against weight gain.[1]"
"Whether such a pill also works in humans may be answered sooner than expected. Pharmaceutical giant GlaxoSmithKline is currently testing GW501516 in obese and diabetic patients as a way of improving their good cholesterol, or HDL, levels. The company says that it has not looked to see how the drug affects endurance or weight but that it plans to do further tests [1]."
In conclusion, I would abuse it.
References:
1.Martindale, D The Muscle Twitch Switch Scientific American December 13, 2002
2.http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15597975
3.http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15057233
The key protein involved is a protein that has been idetified as PPAR-delta. It was noted to be involved in the break down of fat. Experiments also showed that activating PPAR-delta raised metabolism and helped the mice burn more fat.
Of course now they wanted to know if it would cause them to burn excess fat. So they did what any normal person would do and genetically engineered the mice to produce extra PPAR-delta within their muscle. When the mice were then put on a high-fat, high caloric diet for 13 weeks, the PPAR-delta mice gained only a third of the weight that their unmodified friends did. Heres the big deal: The mice on this diet remained resistant to obesity even when they were kept inactive.
"Although Evans (the biochemist responsable) recognizes the potential for abuse by athletes, he believes that his work has more practical implications in treating metabolic ailments, including obesity and heart disease. Patients with such conditions often cannot exercise because of their weight or other complicating problems. "This work could lead to an exercise pill that gives many of the benefits of training without the need to sweat," Evans predicts. Indeed, in a separate experiment he gave normal mice a drug called GW501516, which activates PPAR-delta directly. The drug caused many of the same changes in muscle and metabolism as those in the transgenic mice, including protection against weight gain.[1]"
"Whether such a pill also works in humans may be answered sooner than expected. Pharmaceutical giant GlaxoSmithKline is currently testing GW501516 in obese and diabetic patients as a way of improving their good cholesterol, or HDL, levels. The company says that it has not looked to see how the drug affects endurance or weight but that it plans to do further tests [1]."
In conclusion, I would abuse it.
References:
1.Martindale, D The Muscle Twitch Switch Scientific American December 13, 2002
2.http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15597975
3.http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15057233
Comment