HCG dosing q & a

[superdog]

TweetOK guys, I've been reading up on HCG and as much as I value the input from any FG member I'm getting a LOT of conflicting information. I will use HCG in my next cycle and it will be my first time. I AM prone to gyno (got milk?) and am concerned about getting more if it. Also got a touch of shrinkage on the last 12 weeker cycle and (they did come back) don't want more.

How have you used HCG? and with what results?

[prolangtum]

TweetDuring cycle I have had good luck with 500ius e3d with 10mgs of nolva for gyno protection. I had nuts to make a cow jealous.

[HungarianBeast]

TweetI agree, 500iu e3d or e4d.

[FUZO]

TweetIVE USED IT EVERY SAT SUNDAY 500IUS AND 20MG OF NOLVE ED THROUGH OUT MY CYCLE.

[edvedr]

Tweetand make sure you shoot it directly into your testicle

[edvedr]

Tweet

[sullen]

Tweet

and make sure you shoot it directly into your testicle

comman sense should tell you that

[SMILEY FACE]

Tweeti like it wt 1000ius every 5 day for 1 month=5000ius a month, 5 shots..

[SMILEY FACE]

Tweet

and make sure you shoot it directly into your testicle

into ur left one and right one :p

[prolangtum]

Tweetwhichever one hangs lower

[JsJs24]

TweetI know you guys are joking with him but I have to say it. Superdog, HCG is administered one of two ways, either by intramuscular injection or sub-q.

[TSR1969]

Tweetyou sick fucks made me cringe with that advice, i am still holding my balls thinking of it!! i do 500 sat/sun like fuzo and it works fine. (i swear my balls just drew up a bit as i looked at my slin pins in the fridge)

[superdog]

TweetHoly shit! you were kidding about the ball thing? I already figured out that it hurts a lot less if you ice 'em up first.

he he
OK seriously, your advice seems to advise two things, either 500 once a week for the cycle or 1000 every fifth day for a month. Which do you think is best? Seriously, I'm prone to gyno and shrinkage (the right one is tough the the left one goes like a rasin... well not quite but you get the idea.)

[edvedr]

Tweetlol yes i was kidding

[JohnnyB]

TweetIf you have problems with gyno I wouldn't do 1000iu e5d or anything over 500iu. Sat and sun are fine but that was the old way of doing small doses during a cycle. The half-life of HCG is about 64 hours, so e3d is the new line of thinking, I recomend 3-5 day just because everyone is different, at 300-500iu.

The reason I wouldn't do the 1000iu if I were gyno prone, is it could elevate estrogen(E2). I'll post a study that shows 1 dose of 1500iu elevates E2, where 5 doses of 300iu doesn't give the E2 spike. I know the study doesn't say anything about 1000iu, but if you are prone to gyno why take the chance.

Posted by hhajdo at S’ology

Differential effect of single high dose and divided small dose administration of human chorionic gonadotropin on Leydig cell steroidogenic desensitization.

Smals AG, Pieters GF, Boers GH, Raemakers JM, Hermus AR, Benraad TJ, Kloppenborg PW.

This study compared the effect of a single high dose of hCG (1500 IU) with that of the same dose administered in multiple small doses (300 IU, once daily for 5 days) on Leydig cell steroidogenesis. Administration of a single high dose of hCG to seven healthy men raised the mean plasma testosterone (T) level to peak levels 2.1 +/- 0.2 (SEM) X the baseline value at 48 h. Thereafter plasma T decreased to below normal (0.7 +/- 0.1 X baseline) 7 days after the injection. The mean 17-hydroxyprogesterone (17-OHP) level peaked at 24 h (2.5 +/- 0.2 X baseline) and then also fell to a nadir value of 0.6 +/- 0.2 X baseline on day 7. Reflecting the early accumulation of 17-OHP over T, the 17 OHP/T ratio reached its maximum (1.6 +/- 0.1 X baseline) at 24 h at the same time when plasma estradiol [(E2) 4.4 +/- 0.6 X baseline] and the ratio E2/T (2.7 +/- 0.3 X baseline) achieved their maximal values. Administration of 1500 IU hCG in five divided doses of 300 IU daily increased the mean plasma T levels to peak value of 2.1 +/- 0.2 X baseline at 5 days and the levels remained elevated thereafter. The response of T as reflected by the area under the curve was almost twice as great as in the single dose study (2844 +/- 360 vs. 1647 +/- 214). In contrast to the single high dose experiment, mean plasma 17-OHP levels in the divided dose protocol did not peak at 24 h but only gradually increased. As the increase of T exceeded the 17-OHP increase at almost all time intervals, no accumulation of 17-OHP over T occurred as in the single dose experiment. Instead the 17-OHP/T ratio fell to a nadir value of 0.6 +/- 0.1 X baseline on day 7. The initial E2 peak was absent in the divided dose protocol and the E2/T ratio only marginally increased. Considering both experiments together a close relation was found between the hCG-induced increases in E2 and 17-OHP (r = +0.88, P less than 0.001), as well as the ratio 17 OHP/T (r = +0.64, P less than 0.02).

JohnnyB