always heard take nolva for pct....

[hongkongguy]

Tweetif i have enough aromasin,can i take it throughout the cycle and pct instead??

[LOCO]

Tweetyes aromasin works great... one of the best antiestrogens available......

[Drenten]

Tweet

Originally posted by hongkongguy
if i have enough aromasin,can i take it throughout the cycle and pct instead??

During cycle Aromasin is useful, but it will not help with PCT.

Stick with Nolvadex or Clomid for PCT.

[Slightly Enhanced]

TweetSuper Chicken said you can use it in the Proviron thread,

https://fitnessgeared.com/forum/showt...light=proviron

called it by exemestane

"im thinking exemestane, nolva, and proviron would be an awesome PCT. exemestane is unmateched at keeping estro from binding, the nolva will take care of that last 3-5% of estro exem doesnt get, and it will help lipids, and the proviron, shoudl help improve hardness, and mood since your androgen levels are still somewhat elevated. oooooh i cant wait anyway lets not get off topic here. exemestane can be another thread later."

[Pheedno]

TweetActually, AI's are beneficial in PCT. Now, I've never seen any studies on inactivators, but they will not inhibit PCT

Aromatase inhibitors in men:

The effect of aromatase inhibition on male gonadotrophin and sex steroid concentrations is illustrated in the paper by Trunet et al. (1993): 2.5 mg letrozole suppressed plasma oestradiol concentrations to less than 50% of pretreatment after 2 days, with recovery to approximately pretreatment values after 6 days. These decreases were accompanied by increased gonadotrophin concentrations, with resultant increases of approximately 50% in plasma testosterone. These results, and those previously published (Bhatnagar et al. 1992) on the effects of fadrozole in men, indicate that the aromatization pathway is of major importance in the regulation of gonodotrophin secretion by aromatically androgens

[Drenten]

Tweet

Originally posted by Pheedno
These decreases were accompanied by increased gonadotrophin concentrations, with resultant increases of approximately 50% in plasma testosterone.

Interesting. I had never heard of Exemestane being useful at restoring testosterone levels.

[Pheedno]

TweetNo, that study was with letrozole. I havn't seen a study on inactivators YET. I assume since the are relatively new to the table, completion hasn't been achieved

[Drenten]

TweetI found this information at FDA website:

Other Endocrine Effects: Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17-dihydrometabolite for the androgen receptor, however, is 100-times that of the parent compound. Daily doses of exemestane up to 25 mg had no significant effect on circulating levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxy-progesterone. Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose- dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily exemestane doses of 2.5 mg or higher. Slight, nondose-dependent increases in serum lutenizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level.

Sounds like you would have to use quite a high dosage for PCT for it to be useful. That is, if you were to depend solely on Exemestane for PCT. That would be a very expensive experiment.

[hongkongguy]

Tweetactually,i wanna take aromasin throughout my cycle,hcg before clomid then.....keep taking aromasin for one month instead of nolvadex.