Femera post cycle?

[deepinu]

TweetI just started post cycle therapy..and i am running clomid for 4 weeks and i wanted to run a little bit of nolva with it...but i am tight on cash and i cant spring for the nolva now and i have some femara left over....is this effective post cycle??...or is it a waste and should i save it for my next cycle when i need an anti-e?

[pigmeat]

Tweetdo not use femera post cycle! It has a nasty estrogen rebound, and has a negative efect on your sex drive too. You will have hard enough time with sex drive during Pct.

[orion76]

Tweetestrogen rebound? how does that work?

[orion76]

TweetIf you're running clomid you dont really need to run nolva with it, they both kinda do the same thing anyway.

[pigmeat]

Tweetclomid and nolva together is one of the best choices for pct. Orion, I am not sure what causes the rebound from letrozole, but it doesnt happen with anastrozole, or aromasin. Nolva will give you a rebound, but that is from free flowing estrogen left in the system.

[deepinu]

Tweeti've never noticed a rebound from femara...i have used with heavy test cycles and had no rebound....maybe because of the clomid and nolva??...anyhows ...bump for more info

[orion76]

Tweetfemara stops test from converting to estrogen, if your test is back to normal or lower than normal and you stop taking femara then where does the estrogen "rebound" come from?

[pigmeat]

TweetHere is one study showing letro will cause rebound.


Clin Breast Cancer 2000 Sep;1 Suppl 1:S68-73

Comparison of in vitro exemestane activity versus other antiaromatase agents.

Soudon J.

Anastrozole, letrozole, and exemestane are the most selective and potent oral antiaromatase agents currently available. However, in vitro and in vivo studies comparing these agents are lacking. Anastrozole and letrozole are reversible, competitive nonsteroidal type II inhibitors, whereas exemestane is an irreversible steroidal type I inactivator. The study was conducted to determine the impact of this characteristic on in vitro residual aromatase activity and protein levels after incubation of JEG-3 cells with aminoglutethimide (a type II inhibitor), anastrozole, exemestane, or letrozole. Aromatase activity was measured after various incubation times with each antiaromatase agent at a concentration 10 times higher than IC50 (concentration giving 50% inhibition). Only exemestane induced a residual inhibition of aromatase activity after its removal, without any change in the aromatase protein level. Aromatase activity increased after preincubation of JEG-3 cells with either aminoglutethimide or anastrozole without any change in the aromatase protein level. The aromatase protein level increased rapidly when cells were incubated with letrozole and aromatase activity inhibition disappeared immediately after removal of the drug. The breakthrough effects in aromatase activity or protein levels observed after treatment with reversible inhibitors may be a factor in therapeutic failure with these agents. These results suggest a possible advantage for exemestane because it is the only clinically available oral irreversible aromatase inactivator.

[orion76]

TweetThis abstract says that after discontinuation of letrozole the aromatase inhibition disappeared. It basically suggests that when you stop taking this drug its effects stop too.

But if your test is back to normal or lower than normal and you stop taking femara and aromatase inhibition disappears then there is not much testosterone to aromatise and thus there will be no "estrogen rebound".

[jcp2]

Tweetwhy take an aromatase inhibitor post cycle, it will lower estrogen to almost nill. your estrogen to test ratio will be messed up post cycle because their is no test, but estrogen should still be below normal. By lowering estrogen to nonexistant levels, you are going to screw with your lipid profiles, and your libido is going to be even more fucked up. Most of the bodys estrogen comes from the aromitization of test, and you have no test, so leave the estrogen alone, it is normal.

[pigmeat]

TweetIn the study, aramatase protien increased rapidly, which means that there will be a higher conversion rate, than there was to begin with. Not good. If your estrogen is high, it will fool your body into lowering test production, as it will act like your estrogen is high due test levels bieng too high.

[orion76]

Tweetpigmeat, sorry bro but you're missing the point, there are not high enough test levels post cycle for the aromatase enzyme to convert to high enough estrogen levels that it is going to cause a problem. If you have been on femara for a while you will have close to no estrogen in your body and if you stop taking femara post cycle there is also not enough of the estrogen precursor (testosterone) to create any substantial amount of new estrogen so this rebound is simply not going to happen. Now if you would stop taking femara mid cycle then yeah, the estrogen levels will become high very suddenly but post cycle it's simply not possible.