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TweetNeuroprotective antioxidants from marijuana.
Hampson AJ, Grimaldi M, Lolic M, Wink D, Rosenthal R, Axelrod J.
Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, Maryland 20892, USA. aidan@codon.nih.gov
Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic cannabinoid receptor agonist delta 9-tetrahydrocannabinol (THC) and cannabidiol, (a non-psychoactive constituent of marijuana), both reduced NMDA, AMPA and kainate receptor mediated neurotoxicities. Neuroprotection was not affected by cannabinoid receptor antagonist, indicating a (cannabinoid) receptor-independent mechanism of action. Glutamate toxicity can be reduced by antioxidants. Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies. Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons
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Tweetpot is a gateway drug. it will stunt your growth and make you grow man boobs. if you do pot you will become a crackhead in a matter of days. you will steal from your mamma and possibly start other drugs such as the dreaded "steroid" which causes your penis to shrink and you to beat your girlfriend while eating a sandwich. MR T says dont do drugs stay in school.
"SHIAT BIOTCH, thats a big ass!"
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TweetOriginally posted by jipped genes
pot is a gateway drug. it will stunt your growth and make you grow man boobs. if you do pot you will become a crackhead in a matter of days. you will steal from your mamma and possibly start other drugs such as the dreaded "steroid" which causes your penis to shrink and you to beat your girlfriend while eating a sandwich. MR T says dont do drugs stay in school.
LMAO!
The burden of originality is one that most people don't want to accept. They'd rather sit in front of the TV and let that tell them what they are suppose to like, what they're suppose to buy, and what they're suppose to laugh at. You have Beavis and Butthead telling you what music you're allowed to like and not like, and you've got sitcoms that have canned laughter that lets you know when to laugh if you're too stupid to know when the joke is. People are too lazy and too stupid to think for themselves because America has raised them that way.
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TweetLOL.Originally posted by jipped genes
pot is a gateway drug. it will stunt your growth and make you grow man boobs. if you do pot you will become a crackhead in a matter of days. you will steal from your mamma and possibly start other drugs such as the dreaded "steroid" which causes your penis to shrink and you to beat your girlfriend while eating a sandwich. MR T says dont do drugs stay in school.
Elite Senior Resident
Tweetare you on the pot
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TweetSome people smoked crack before weed! I find it funny that x is cheaper than nugz and easier to get some war on drugs poor dank farmers
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