PQQ (pyrroloquinoline quinone), a novel cofactor with B vitamin like-activity and antioxidant function, provides powerful support for a wide range of functions in the body. Numerous studies have indicated that PQQ supports brain, cognitive, and nerve health, cardiac and cancer protection, mitochondria biogenesis or birth of new mitochondria, energy production, and stress tolerance. The antioxidant status of PQQ is 5,000 times more potent than vitamin C. It is a new kid on the block here at Wellness Resources. It is a commanding nutrient with remarkable potential.
Sources of PQQ

Discovered in 1979, PQQ is a small quinone compound with vitamin-like properties and a massively powerful redox agent or an extreme antioxidant. It is heat stable and water soluble. It is found in very small amounts in all live plants, animals, humans, and soil. Some of the highest food sources are found in green tea, fermented natto, spinach, green peppers, parsley, and kiwi. It is also found in higher amounts in human breast milk, as it is vital for normal cellular growth and development.
PQQ: A Powerful Cyclical Antioxidant

PQQ is considered a redox agent with the ability to drive repeated oxidation and reduction reactions. This means that it is heavily involved with cell signaling pathways and provides cyclical antioxidant effects. It is recycled by glutathione allowing the redox or regenerative cyclical process to occur. PQQ can undergo the process of getting used up to quench free radicals and back to original form up to 20,000 cycles before it is depleted. Quercetin has approximately 800 catalytic cycles, green tea extracts 75-700 cycles, and vitamin C has a potential of four cycles. Because PQQ is found throughout all life forms, many of PQQ’s functions are universal not only in bacterial and plant forms but to humans.
Mitochondria Biogenesis, Lactic Acid, and CRP

Some of the most promising benefits of PQQ are with mitochondrial biogenesis or the birth and regulation of healthy mitochondria. Mitochondria are small energy or ATP producing structures found in cells throughout the entire body. Skeletal, heart, and smooth muscle and the brain have the highest amounts and need for healthy mitochondria in order to function. Mitochondria burn glucose and fat for fuel generating energy for the entire body. Animal studies show that mice that were deficient in PQQ had 20-30 percent less mitochondria present and reduced mitochondria function. Another study showed that animals lacking PQQ negatively impacted over 200 gene signals associated with mitochondria and major signaling pathways like PGC-1

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