New discoveries advance ability to detect hCG doping in sport

[BABY1]

TweetImportant new peer-reviewed research conducted by Getachew A. Woldemariam and Dr. Anthony W. Butch may help increase the ability to detect athletes who are taking human chorionic gonadotropin (hCG) as a doping substance to enhance athletic performance. The research, which was published in the August issue of Clinical Chemistry, was funded by the Partnership for Clean Competition (PCC) in order to further advance the ability to detect the use of hCG, which stimulates testosterone production and is a banned substance on the World Anti-Doping Agency list.

Through their research, Woldemariam and Butch developed ways to specifically measure several forms of hCG in urine. While urinary hCG is a marker of pregnancy in females, hCG is used by men to increase testosterone or restore testosterone production after doping with synthetic anabolic steroids. By specifically measuring the various forms of hCG in male urine, the new test can better detect athletes who are taking hCG as a doping substance to enhance performance. In addition, the test should allow a definitive characterization of familial hCG syndrome.“This immunoextraction and tandem mass spectrometry method for measuring the major isoforms of chorionic gonadotropin in urine is a significant improvement over currently available immunoassays,” says Butch. “The method has superior analytical specificity and will greatly enhance the ability to detect male athletes who dope with various forms of chorionic gonadotropin.”
According to Dr. Larry Bowers, PCC Scientific Advisory Board Chair and USADA Chief Science Officer, “The measurement of male urinary hCG in anti-doping has been an area of concern for many years. This important research has not only developed a sensitive and specific LC-MS/MS assay which will help us to detect the various forms of hCG and those who use it to cheat their competitors, but Woldemariam and Butch have greatly added to our knowledge about hCG excretion after administration. With the specificity of the LC-MS/MS method, it should be possible to provide additional information about the concentration of intact hCG in male urine samples who have not doped and therefore increase the sensitivity of the test.”
Based on the results of this study, the World Anti-Doping Agency (WADA) is in the process of developing new guidelines for WADA-accredited labs to conduct tests.About AACC

Dedicated to achieving better health through laboratory medicine, the American Association for Clinical Chemistry (AACC) brings together more than 50,000 clinical laboratory professionals, physicians, research scientists, and business leaders from around the world focused on clinical chemistry, molecular diagnostics, mass spectrometry, translational medicine, lab management, and other areas of breaking laboratory science. Since 1948, AACC has worked to advance the common interests of the field, providing programs that advance scientific collaboration, knowledge, expertise, and innovation. For more information, visit www.aacc.org.
Clinical Chemistry is the leading international journal of clinical laboratory science, providing 2,000 pages per year of peer-reviewed papers that advance the science of the field. With an impact factor of 7.9, Clinical Chemistry covers everything from molecular diagnostics to laboratory management.

[BABY1]

TweetThe problem I see with going on the assumption of "positive for hcg " in mens' urine is that men can also have hcg in their urine when they have tumors/testicular cancer.

[6p6]

TweetIt's a cat and mouse game...I know most agree pro sports should be able to use whatever they want!


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[guns01]

Tweethow in the hell are you going to get a bump in athletic performance with hcg? it may spike you a bit but nothing that is going to provide any significant increase in size or performance. they waste so much freaking money when they could be focusing on treating and curing diseases and other things

[6p6]

Tweet^exactly


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