lantus solostar ?

[MOUNTAIN-MAN]

Tweetinsulin glargine (rdna origin) is this the fast acting or the slow acting slin never used it before thanks to any one who can help

[MOUNTAIN-MAN]

Tweetpic

[guns01]

Tweetman i have no idea on this one. all the redi pins i have seen actually say either humilin r humalog or humilin n. those are the only 3 i have ever seen personally

[MOUNTAIN-MAN]

Tweetthis is what i could find i think it would be safe to use am workout then keep carbs up all day any thoughts




Insulin glargine








From Wikipedia, the free encyclopedia
(Redirected from Lantus SoloSTAR)
Insulin glargine
Systematic (IUPAC) name
Recombinant human insulin
Clinical data
Trade names Lantus
AHFS/Drugs.com monograph
MedlinePlus a600027
Pregnancy cat. C (US)
Legal status POM (UK) ℞-only (US)
Routes Subcutaneous
Identifiers
CAS number 160337-95-1 Yes
ATC code A10AE04
DrugBank DB00047
UNII 2ZM8CX04RZ
KEGG D03250 Yes
Chemical data
Formula C267H404N72O78S6
Mol. mass 6063 g/mol
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Insulin glargine, marketed by Sanofi-Aventis under the name Lantus, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes. It consists of microcrystals that slowly release insulin, giving a long duration of action of 18 to 26 hours, with a "peakless" profile (according to the insulin glargine package insert). Pharmacokinetically, it resembles basal insulin secretion of non-diabetic pancreatic beta cells. Sometimes, in type 2 diabetes and in combination with a short acting sulfonylurea (drugs which stimulate the pancreas to make more insulin), it can offer moderate control of serum glucose levels. In the absence of endogenous insulin—type 1 diabetes, depleted type 2 (in some cases) or latent autoimmune diabetes of adults in late stage—insulin glargine needs the support of fast acting insulin taken with food to reduce the effect of prandially derived glucose.
Contents [hide]
1 Medical uses
1.1 Mixing with other insulins
2 Adverse effects
2.1 Cancer
3 Pharmacological specifications
3.1 Mechanism of action (pharmacodynamics)
3.2 Acceptance and repartition in the body (pharmacokinetic)
4 Development
5 References
6 External links
Medical uses[edit]

The long acting insulins, which includes insulin glargine, do not appear much better than neutral protamine Hagedorn (NPH) insulin but have a significantly greater cost making them, as of 2010, not cost effective.[1] It is unclear if there is a difference in hypoglycemia and not enough data to determine any differences with respect to long term outcomes.[2]
Mixing with other insulins[edit]
Unlike some other longer-acting insulins, glargine must not be diluted or mixed with other insulin or solution in the same syringe.[3] However, this restriction has been questioned in clinical trials.[4]
Adverse effects[edit]

Cancer[edit]
On June 26, 2009, Diabetologia published the results of four large-scale registry studies from Sweden, Germany, Scotland and the rest of the UK. The German study, of around 127,000 insulin-treated patients from an insurance database, suggested a possible link between insulin glargine and increased risk of developing cancer.[5] The risk of cancer was dose-dependent, with those taking higher doses of insulin glargine apparently at increased risk.[6] Whilst the authors stressed the limitations of the study and recommended that patients prescribed Lantus continue to take the drug, the results led to the EASD making "an urgent call for more research into a possible link between use of insulin glargine and increased risk of cancer."[7]
The European Medicines Agency (EMEA) responded, stating that the results of the four studies were inconsistent, and that a relationship between insulin glargine and cancer could neither be confirmed nor excluded.[8] They announced that they would undertake further detailed assessment of the studies’ results and any other relevant information, including several potentialconfounding factors that had not been fully taken into account by the studies. Patients being treated with insulin glargine were advised to continue their treatment as normal. [8] The following month, the EMEA reported back, concluding that "the available data does not provide a cause for concern and that changes to the prescribing advice are therefore not necessary.”[9]
The American Diabetes Association (ADA) also responded to the Diabetologia report, describing the published registry studies as “conflicting and confusing” and “inconclusive”. They advised patients against discontinuing insulin glargine and warned against "over-reaction".[10]
Type 2 diabetics who used insulin glargine had a 2.9-fold greater chance of cancer, while those who took the generic drug metformin had an 8 percent lower risk, according to a study presented on 9 December 2011 at the San Antonio Breast Cancer Symposium. Researchers examined medical records of 23,266 patients in southern Sweden.
The researchers were unable to identify which types of cancer were most common among insulin glargine users, said Hakan Olsson, lead researcher and professor of oncology at Lund University. They plan to follow the patients, and investigate different forms of treatment for Type 1 diabetes, including Novo Nordisk A/S’s long- acting insulin Levemir, to tease out any differences, he said.
“Women should be aware that diabetes and breast cancer may be related,” Olsson said in a telephone interview. “The diabetes itself could play a role in the development of cancer and now data is emerging that drug therapy may also be important in relation to cancer.”[11]
Three studies completed in 2012 with large numbers of experimental subjects found no link between use of insulin glargine and cancer.[12]
Pharmacological specifications[edit]

Mechanism of action (pharmacodynamics)[edit]
Insulin glargine have substitution of glycine for asparagine at N21 (Asn21) and two arginines added to the carboxy terminal of B chain. The arginine amino acids shift the isoelectric point from a pH of 5.4 to 6.7, making the molecule more soluble at an acidic pH, allowing for the subcutaneous injection of a clear solution. The asparagine substitution prevents deamidization of the acid-sensitive glycine at acidic pH. In the neutral subcutaneous space, higher-order aggregates form, resulting in a slow, peakless dissolution and absorption of insulin from the site of injection.[13] It can achieve a peakless level for at least 24 hours.
Acceptance and repartition in the body (pharmacokinetic)[edit]
Insulin glargine is formulated at an acidic pH 4, where it is completely water soluble. After subcutaneous injection of the acidic solute (which can cause discomfort and a stinging sensation), when a physiologic pH (approximately 7.4) is achieved the increase in pH causes the insulin to come out of solution resulting in the formation of higher order aggregates of insulin hexamers. The higher order aggregation slows the dissociation of the hexamers into insulin monomers, the functional and physiologically active unit of insulin. This gradual process ensures that small amounts of insulin glargine are released into the body continuously, giving an almost peakless profile.

[MOUNTAIN-MAN]

Tweetany input from the other fg masters

[MOUNTAIN-MAN]

Tweetwell off tothe gym to give it a go postworkout with 150 grams of carbs 50 grams protien and 10 grams creatine then a hr later 45 grms prottien and 100 grams carbs ill keep this post updated

[MOUNTAIN-MAN]

Tweetdid work out sleepy as hell had 60g proten 10 gram creatine ad 125 gramm carbi user

[guns01]

Tweetit's such a long acting insilin man i would keep the carbs pretty high throughout the day and keep some dextrose or sugar/jelly beans on hand close by at all times. i dont know if it peaks more than one or two times a day but better safe than sorry

[MOUNTAIN-MAN]

Tweetii have goodies with me all day

[MOUNTAIN-MAN]

Tweeti dont ilke this i have had a carb load every hr and a half and still feel sleepy and got the hick ups i will not be using this slin

[MOUNTAIN-MAN]

Tweetstill fel week and bad head ake from it wont touch itagin thank god i only useed 10iu

[guns01]

Tweet

still fel week and bad head ake from it wont touch itagin thank god i only useed 10iu

yeah man, drop that puppy and get some log or at least humilin r

[MOUNTAIN-MAN]

Tweetno dought it was free now i know why i feel like i got hit by a truck

[MOUNTAIN-MAN]

Tweetguess i wont feel any better till wensday am since its a 24 hr spike