Zinc helps fight infection and inflammation by boosting the body's immune response

[BABY1]

TweetralNews) Infection from bacterial and viral agents can pose a significant threat to human health, as it fuels the flames of systemic inflammation known to contribute to cancer, heart disease, dementia, diabetes and stroke. Many lifestyle factors, including diet, stress and exposure to environmental and household toxins contribute to elevated levels of inflammation throughout the body that never subside, creating a cellular environment that is favorable to disease propagation. Fortunately, there are a number of natural compounds and nutrients that help combat inflammation and lower risk of infection and chronic disease.

A research team from Ohio State University has released the result of a study revealing how zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out of control inflammation that can be damaging and even deadly. Working with human cell cultures, the scientists have demonstrated how a specific protein ushers zinc into key cells that stimulate a critical immune response to fight against infection. The mineral interacts with a cellular process that neutralizes infection and helps balance the normal immune response.

Zinc activates the innate immune response to help fight viral and bacterial pathogens

Scientists present groundbreaking work that demonstrates for the first time how zinc disables an important pathway to effectively ensure that the immune response does not spiral out of control in response to an infection, and similarly to perpetually elevated levels of inflammation referred to as systemic. Senior study author, Dr. Daren Knoell commented "Without zinc on board to begin with, it could increase vulnerability to infection... our work is focused on what happens once you get an infection... if you are deficient in zinc you are at a disadvantage because your defense system is amplified, and inappropriately so."

Monocytes, which are white blood cells that provide the first line of defense against an invading pathogen, were extracted from human blood samples to determine what happens when the immune response is launched. Researchers found that when a pathogen is detected, a series of complex responses occur to wake the innate immune response utilizing the nuclear-factor kappa beta pathway (NF-kB). The team showed that once NF-kB is activated, a gene is expressed that allows zinc to be ushered from the bloodstream into the cell where it can bind with proteins that block the activity of the pathogen and halt excess inflammation.

Dr. Knoell concluded, "We believe that our findings help to narrow an important gap that has existed in our understanding of how this relatively simple metal helps us defend ourselves from infection." Zinc deficiency affects two billion people around the world, representing an estimated 40 percent of the elderly in the U.S., and helps to explain why our aging population is unable to fight the most common infections. Dietary sources of zinc include beans, nuts, some shellfish, whole grains, fortified cereals and dairy products. Health-minded individuals may want to avoid meat, dairy and grain sources and supplement with 15 to 25 mg per day to fight infection and systemic inflammation.

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[bandaidwoman]

TweetVery interesting read. However, remember, In -vitro studies are a good beginning but until in- vivo studies are done with good randomized clinical trials, we don't really know how this will apply in a biological organism. The problem with studying monocytes or any infection fighting cells in a petri dish is you lose the symphony of coordinating hormones and signals that turn off and off immune cells that are released by the other immune fighting cells that reside in the body. Just pick up a textbook on immunology. The monocytes do not act alone. That is why 80% of all drug clinical trials end when we get to stage I or II, because what happens in a petri dish, doesn't translate to what happens in a living breathing organism.

[bandaidwoman]

Tweet, don't forget, high doses over a long period of time can cause anemia ( due to chelating copper , in fact, that is how we treat Wilson's disease) . Dosages over 90mg per day over a long period of time may inversly suprress the immune system and have a negative impact on high-density lipoprotein, or HDL, cholesterol levels.

[BABY1]

Tweet

, don't forget, high doses over a long period of time can cause anemia ( due to chelating copper , in fact, that is how we treat Wilson's disease) . Dosages over 90mg per day over a long period of time may inversly suprress the immune system and have a negative impact on high-density lipoprotein, or HDL, cholesterol levels.

Yes i do kow that to much zinc is not good. people tend to think more is better sometimes

[wutlisstrice]

Tweetintresting article and additions