Int J Sports Med 1991 Aug;12(4):413-8 Related Articles, Links
Influence of anabolic steroids on body composition, blood pressure, lipid profile and liver functions in body builders.
Kuipers H, Wijnen JA, Hartgens F, Willems SM.
Dept. of Physiology, University of Limburg, Maastricht, The Netherlands.
The effects of anabolic steroids on body composition, blood pressure, lipid profile and liver functions were studied in male body builders who received a weekly i.m. injection of nandrolone-decanoate (100 mg) or placebo for 8 weeks in a double blind way. In addition, 5 body builders received the same dosage of nandrolone-decanoate or placebo, in a double blind cross-over design during two 8-week periods, interspersed by 12 weeks. Anabolic steroids induced a 25-27% decrease in HDL-cholesterol, which was virtually reversed 6 weeks after cessation of drug use. In the SAD group an increase in diastolic blood pressure was observed, which returned to pre-anabolic values approximately 6 weeks after cessation of drug administration. No deleterious effects of anabolic drugs on plasma activity of liver enzymes were found. Increases in lean body mass were found in all groups, though the increase in the subjects who received anabolic steroids was superior to that in the placebo-treated subjects. The increase in lean body mass suggests increases in muscle mass.
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Int J Sports Med 1985 Feb;6(1):24-9 Related Articles, Links
Physical health and fitness of an elite bodybuilder during 1 year of self-administration of testosterone and anabolic steroids: a case study.
Alen M, Hakkinen K.
An adult male bodybuilder of international level, who had decided to complement his training by self-administering the androgenic hormones (actually 53 mg/day), volunteered as a subject for investigation of his physical health and fitness over a training period of 1 year including only a 4-week abstinence from drugs in the middle of the year. The subject was able to gain greatly in fat-free weight (from 83 to 90 kg), in mean fiber area of the VL muscle (enlargement of 11.4% after a half year's training), and in maximal strength (from 5145 to 5948 N). The high level of serum testosterone and low level of serum SHBG observed tend to strengthen suggestions of the anabolic effects of androgenic steroids during training. The subject's health status was affected. A high serum E2 level during the use of androgens, atrophic testicles, and low LH, FSH, and T levels after drug withdrawal indicate that sustained testosterone/anabolic steroid administration affects the function of the pituitary and leads to long-lasting impairment of testicular endocrine function, and consequently to azoospermia and cynegomastia. The observed decrease in serum HDL-cholesterol (from 1.59 to 0.44 mmol/l) and in HDL2-cholesterol (from 0.42 to 0.01 mmol/l) may indicate a higher risk for atherogenesis.
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Int J Sports Med 1985 Jun;6(3):139-44 Related Articles, Links
Serum lipids in power athletes self-administering testosterone and anabolic steroids.
Alen M, Rahkila P, Marniemi J.
The purpose of the present investigation was to study the effects of testosterone and anabolic steroids on serum lipids in power athletes. Altogether 11 national top-level adult athletes completed the study. Five of them volunteered for the study group and the rest for controls. The follow-up consisted of 9 months of a strength training period. During the first 6 months, the subjects in the study group self-administered androgenic steroids on an average of 57 +/- 24.9 mg/day. The most interesting observation was the extremely low high-density lipoprotein (HDL) and HDL2 cholesterol concentrations of the androgen users. After 8 weeks of training, the study group had significantly (P less than 0.05) lower HDL cholesterol concentrations than the control group (0.53 +/- 0.11 and 1.14 +/- 0.19 mmol/l, respectively). This difference remained significant from 8 to 32 weeks of training. No systematic changes were observed in the control group. The HDL2 cholesterol concentration decreased by about 80% (P less than 0.01) and HDL3 cholesterol by about 55% (P less than 0.01) from the onset values in the study group. A substantial decrease in HDL cholesterol to total cholesterol and in HDL2 cholesterol to HDL3 cholesterol ratios were also noticed under the influence of exogenous androgens. The results of this study suggest that the sustained use of testosterone and anabolic steroids have a marked unfavorable effect on the pattern of HDL cholesterol in the serum of male power athletes
I eat at least 6 times a day to build my body
I pray at least 6 times a day to build my soul