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Igf-1 Side Effects

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  • Igf-1 Side Effects

    i have looked all over the net for igf-1 side effects but all i read is good things about it.. i havnt found any thing negative about it... can some one list me ALL the possible side effects of IGF-1 ???

    also i wana know if u guys think its true that many people blame IGF-1 for giving that pregnant look to some of the top bbers... whats ur input on that???


    Also need to ask , do u think its better to combine igf-1/insuline/test( or other AS) for better results?? should u use it oncycle or all the way in cycle and through post cycle ??

  • #2
    hey look at this guys, what do u say about this article?? can u say good bye to IGF1?


    originally posted by bone @ cjm
    By Cy Willson.....

    IGF-1: Worst Bodybuilding Drug Ever?

    Q: What ever happened to IGF-1? It was talked about in 'roid books in the early '90s but you don't hear much about it now, except for a few sleazy supplement companies who are using the name.

    A: IGF-1 can allow for hypertrophy of muscle. Will it do such a thing when administered to humans? Yes. However, the gains seen really aren’t spectacular. More often than not, they don’t even come close to gains seen using androgens.

    For the most part, people should realize that IGF-1 is primarily responsible for GH’s anabolic effects in skeletal muscle as well as cell proliferation, leading to enlarged internal organs and increasing the risk for cancer dramatically. Oh, and this most certainly includes Long R3 IGF-I as I know some people will try to argue that it's much safer.

    Well, in order to give you the total picture, I’m going to go over some basic molecular biology as well as list the direct evidence we have concerning the side effects of IGF-1 and yes, that includes Long R3 IGF-I.

    First, people should understand that in the human cell cycle, growth requires growth factors in general. Seems simple enough. The next thing people need to understand is that for a normal cell, death is something that'll inevitably occur via loss of telomerase or apoptosis (programmed cell death). Again, I can’t overemphasize enough that the default pathway in humans is death, not growth. (Reassuring, isn't it?)

    Now, when you hear of cancer, malignant cancer, people tend to think of uncontrolled cell division. Essentially though, these transformed cancerous cells are immortalized. Now, many changes are required for this to occur (i.e. increased telomerase, increased bcl-2, increased myc and decreased p53). In the development of cancer, we tend to think of carcingogens consisting of both initiators and promoters. For instance, some initiators are UV radiation and tobacco smoke, usually causing DNA damage or mutation, whereas promoters tend to stimulate cell division. A few examples are phorbol esters, hormones (e.g. estrogens) and yes, growth factors.

    Now, keep in mind both events, initiation and promotion, are required for the development of malignant cells. As a side note, viral infection can also lead to the two events, but I digress. Anyhow, normally a cell serves its purpose and then dies via apoptosis. However, malignant cells don’t undergo apoptosis. They are, as I said before, immortal. The normal triggers to apoptosis are DNA damage, loss of cell-matrix contact, loss of cell to cell contact, and last but most certainly not least, lack of growth factors.

    When you introduce growth factors, you’re providing the catalyst for cancer formation, so to speak. Let’s say, for instance, you get many sunburns during your lifetime. Now, let’s say that one cell has its DNA damaged or altered. This, in and of itself, isn’t too much of a concern as this is only one part of the equation, the iniation. The second part is the promoter (including growth factors).

    Well, let’s imagine we introduce growth factors to the cell which has damaged or mutated DNA and it then begins to divide at a more and more rapid rate until it won’t stop. Voila, you have a tumor, which is now capable of even faster growth as well as being invasive (able to invade surrounding tissues) and metastatic (able to cause growth in completely unrelated and distant tissues) in regard to other tissues.

    In other words, you now have a malignant tumor, which we commonly refer to as cancer. The fact is, cancer stems from just one cell, just one cell, which begins to divide uncontrollably. People often talk about GH and the side effects thereof, but what most don’t realize is that many of those side effects aren't necessarily mediated by growth hormone but by IGF-1.

    Many people may go their whole lives with some DNA damage (or mutation rather) and never have cancer, but with the addition of growth factors, you’re asking for trouble. Even more specifically, you can increase the risk of developing rare forms of cancer, like sarcomas, which are tumors commonly found in connective tissues (i.e. muscle, bone, cartilage, etc.)

    Okay, now on to the more cosmetic side effects. With Long R3 IGF-I, it was shown to stimulate growth of the gastrointestinal tract. IGF-1 actually had no effect on body weight and wet tissue weight of the small and large intestine, whereas Long R3 IGF-I resulted in a 20% increase in the weight of the small and large intestine. This is what's causing a "GH gut" although using Long R3 IGF-I is much, much worse than using GH.

    Something else to keep in mind is that Long R3 IGF-I was shown to be even more potent than IGF-1 in inhibiting apoptosis and thus its potential for causing cancer is many times greater.

    Another idea is that IGF-1 may also keep telomerase activity high, which as we noted previously is a contributing factor for the loss of regulation in terms of cell division. In other words, it again can substantially increase the risk for developing cancer. Long R3 IGF-I was shown to increase telomerase activity in human prostate cancer cells, whereas IGF-1 had no effect.

    So, when I tell you to stay away from IGF-1, I’m actually referring to Long R3 IGF-I as it’s what's most commonly circulated and used. Although both aren't something a person should use, Long R3 IGF-1 is probably the worst choice you can make.

    So, unless you’re an IFBB pro who consistently places in the top ten at popular contests, you should forget about using IGF-1, or specifically the analogue of IGF-1 called Long R3 IGF-I. It’s really not worth the risk. This, out of all the compounds that bodybuilders may use, is probably the worst in terms of potential side effects.

    ---------------------------

    Comment


    • #3
      IAM SAYING NO
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      • #4
        bump... any more opinions on this? I was thinking of trying IGF, and this somewhat worries me

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        • #5
          hmmmm........I'll stick to what i know works.

          A-bombs
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          RIP - Geared
          RIP - BigJ


          flexer01@cyber-rights.net

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          • #6
            I think Im gonna stay away until more is known about this shit. My guts big enough without the enlarged intestines...
            Everything I say is my opinion and should not be listened to by anyone.

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            • #7
              it all sounded so good till i read that over on SM.
              "SHIAT BIOTCH, thats a big ass!"

              A clear concience is a sign of a bad memory.

              husband of the year

              moose riding maple syrup drinking flanel wearing canuck wannabe


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              • #8
                maybe it would be a good idea to just use it occasionally, like post cycle or something..

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                • #9
                  there is no sideeffect free supplement in this world.... This shit is scary though... i think we better of waiting for more research on it

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                  • #10
                    hey bro how are u doing? good i hope!! peace

                    Comment


                    • #11
                      Go to ANIMALS BOARD everyone that took it said they liked it and it has some great info! People sat Gh is shitty and the worst BB drug ever but it has helped me to keep and maintain my gains as well as looked my best while on it!

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                      • #12
                        Originally posted by gearedup
                        Go to ANIMALS BOARD everyone that took it said they liked it and it has some great info! People sat Gh is shitty and the worst BB drug ever but it has helped me to keep and maintain my gains as well as looked my best while on it!

                        bro im not questioning if the stuff gona work or not.. im sure it works great and i am very interested to learn about it just for that reason because it DOES work... but what we are tryin to figure out the probiblity that wer gona develop cancer in a few yrs...

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                        • #13
                          i might give it a try instead of GH with my cycle, not sure yet, i gotta research it a lot more first.

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                          • #14
                            I've posted that same article at MC and LA said that Cy Wilson is nothing but a toolbag that is trying to put IGF-1 down because of competition or soemthing like that so I would take the info in that article with a grain of salt,that's not saying that IGF-1 doesn't have side effects but along those lines that he mentioned is kinda bullshitting if you ask me but I would advice people to do more research on this before you try it like I'm going too.

                            Eat,Learn,Train,Grow
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                            • #15
                              Read animals board he has an entire forum for it, supposedly it is safer than Growth and stronger!

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