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B12 helps make DNA, nerve and blood cells, and is crucial for a healthy immune system and brain. Your metabolism wouldn't run smoothly or function properly without it. B12 is only found in products like eggs, meat, shellfish, and dairy. Most people that don't get enough B12, are more likely to suffer from digestion problems! Stomach acid is key for B12 absorption, as we continue to age our stomach produces less and less. Certain meds, prescription as well as OTC products can affect the production of stomach acid as well. Antacids and products for heartburn are probable #1 on the list.
Absorption should be another concern for many people. Women who take birth control usually have issues absorbing B12 and/or B6!
Drinkers..
Alcohol not only will affect your stomach acid but affect your liver and deplete your liver of B12.
A few signs of b12/b6 deficiency
exhaustion, brain fog , lack of energy , focus. Memory loss, Fatigue, confusion , feel like your always dragging , lowered immune system.

In my opinion Best Treatment usually involves B12 shots, combined with supplementation.
Follow the links below.
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Organizm
B-6
B-12