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Clomiphene citrate (Clomid) is a SERM (selective estrogen receptor modulator) similar to Tamoxifen. Clomid is typically used to induce ovulation in females by blocking estrogen in selective tissue in the body. Clomid opposes the negative feedback of estrogens on the Hypothalamic Pituitary Ovarian Axis which enhances the release of LH and FSH.
Post cycle recovery
I consider Clomid an important recovery drug for post cycle therapy. In men, the effects of Clomid are much more pronounced than women as an increase in FSH and LH will cause a rise in natural Testosterone. After just 7 days of clomiphene citrate administration (100mg daily), mean serum total T and non-SHBG-bound levels in young men increased by a whopping 100% and 304%, respectively, while in older men these values increased by only 32% and 8%, Similar to previous observations, LH and FSH levels showed a significant elevation in response to clomiphene citrate over the response to placebo.
Clomid is a very useful compound at the end of an AAS cycle because Testosterone quickly falls below baseline levels when steroids are withdrawn. This decline in Testosterone then allows the effects of cortisol to wreak havoc on new muscle. The user quickly goes from an anabolic to a catabolic state. Thankfully this crash can be mitigated with Clomid. Clomiphene restores normal Testosterone levels and improves sperm motility in most male patients. Clomid may also be used on cycle to block the effects of estrogen in male breast tissue therefore reducing the likelihood of gynecomastia however Nolvadex seems the preferred medicine for this purpose. Additionally, Clomid supports improved cardiovascular values.
So how do we maximize the benefits of this recovery medicine? First we need to determine the clearance time of the AAS being used. In other words, how long will it take for the steroid to reach baseline Testosterone levels? Most steroids have a published duration in which they are no longer elevating Testosterone above natural levels but this is only an estimate as cycle duration, scar tissue and many multiple depots may extend release times of the AAS administered when using injectable compounds. Once it's determined when to employ Clomid, therapy should be about 4-6 weeks in duration. I like to start with a dose of 50-100mg's daily for 3 weeks and then reduce that dose to 50mg daily the remainder of the therapy. I recommend getting labs after Clomid therapy to determine if recovery was successful. If not, another Clomid course may be needed.
SERM's and female fat reduction?
Some women report a reduction in female pattern fat deposits when employing a SERM during an anabolic androgenic steroid cycle but evidence seems to be to the contrary according to a study on Nolvadex that measured body fat using a dual-energy X-ray absorptiometry (DXA). Body fat increased with Nolvadex use alone. It is likely that the lower body fat observed may be due to the steroid administration not the SERM by itself.
Hypogonadism and low libido
In 2012, 25mg daily Clomid administration was investigated for mitigating low male Testosterone levels and poor sexual function. Essentially the researchers studied Clomid as a treatment for hypogonadism. This treatment lasted for at least 3 months. The Clomid treatment was successful, resulting in about a two times increase of the men's Testosterone levels and improvements in sexual function. Clomid may be considered a therapeutic option for patients with symptomatic male Testosterone deficiency. The chart below provides the Testosterone outcomes by age from this 25mg daily treatment.
Serum Testosterone Outcomes.jpg
All participants reported an improvement in quality of life although younger men more so than older men. Restoring men's Testosterone levels with Clomid increases sexual function and quality of life.
Clomid users have reported various side effects like dizziness, vision problems, emotional swings and nausea. I have personally had mild vision issues while on Clomid but they went away when I stopped using the medicine.
Overall Clomid is a relatively safe compound when used at reasonable dosages and in my estimation is a good option for proper Testosterone recovery and improved sexual function.
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1. Body composition measurements using DXA and other techniques in tamoxifen-treated patients.
2. Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment.
3. Clomiphene Citrate Effects on Testosterone/Estrogen Ratio in Male Hypogonadism
4. Basal prolactin and the behaviour of the gonadotrophins, testosterone, androstenedione, estradiol, and the sex-hormone-binding globulin during stimulation with clomiphene in subjects with spermatogenic disorders.
5. Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate.
6. Clomiphene in the treatment of adolescent gynecomastia. Clinical and endocrine studies.
7. Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study.
8. An investigation of the visual disturbances experienced by patients on clomiphene citrate.
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