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    Thread: Clomid~clomiphene citrate

    1. #1
      heavyiron's Avatar
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      Default Clomid~clomiphene citrate



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      Clomid~clomiphene citrate
      Clomid~clomiphene citrate
      Clomid

      (clomiphene citrate)

      Clomiphene citrate (Clomid) is a SERM (selective estrogen receptor modulator) similar to Tamoxifen. Clomid is typically used to induce ovulation in females by blocking estrogen in selective tissue in the body. Clomid opposes the negative feedback of estrogens on the Hypothalamic Pituitary Ovarian Axis which enhances the release of LH and FSH.

      Post cycle recovery

      I consider Clomid an important recovery drug for post cycle therapy. In men, the effects of Clomid are much more pronounced than women as an increase in FSH and LH will cause a rise in natural Testosterone. After just 7 days of clomiphene citrate administration (100mg daily), mean serum total T and non-SHBG-bound levels in young men increased by a whopping 100% and 304%, respectively, while in older men these values increased by only 32% and 8%, Similar to previous observations, LH and FSH levels showed a significant elevation in response to clomiphene citrate over the response to placebo.

      Clomid is a very useful compound at the end of an AAS cycle because Testosterone quickly falls below baseline levels when steroids are withdrawn. This decline in Testosterone then allows the effects of cortisol to wreak havoc on new muscle. The user quickly goes from an anabolic to a catabolic state. Thankfully this crash can be mitigated with Clomid. Clomiphene restores normal Testosterone levels and improves sperm motility in most male patients. Clomid may also be used on cycle to block the effects of estrogen in male breast tissue therefore reducing the likelihood of gynecomastia however Nolvadex seems the preferred medicine for this purpose. Additionally, Clomid supports improved cardiovascular values.

      So how do we maximize the benefits of this recovery medicine? First we need to determine the clearance time of the AAS being used. In other words, how long will it take for the steroid to reach baseline Testosterone levels? Most steroids have a published duration in which they are no longer elevating Testosterone above natural levels but this is only an estimate as cycle duration, scar tissue and many multiple depots may extend release times of the AAS administered when using injectable compounds. Once it's determined when to employ Clomid, therapy should be about 4-6 weeks in duration. I like to start with a dose of 50-100mg's daily for 3 weeks and then reduce that dose to 50mg daily the remainder of the therapy. I recommend getting labs after Clomid therapy to determine if recovery was successful. If not, another Clomid course may be needed.

      SERM's and female fat reduction?

      Some women report a reduction in female pattern fat deposits when employing a SERM during an anabolic androgenic steroid cycle but evidence seems to be to the contrary according to a study on Nolvadex that measured body fat using a dual-energy X-ray absorptiometry (DXA). Body fat increased with Nolvadex use alone. It is likely that the lower body fat observed may be due to the steroid administration not the SERM by itself.

      Hypogonadism and low libido

      In 2012, 25mg daily Clomid administration was investigated for mitigating low male Testosterone levels and poor sexual function. Essentially the researchers studied Clomid as a treatment for hypogonadism. This treatment lasted for at least 3 months. The Clomid treatment was successful, resulting in about a two times increase of the men's Testosterone levels and improvements in sexual function. Clomid may be considered a therapeutic option for patients with symptomatic male Testosterone deficiency. The chart below provides the Testosterone outcomes by age from this 25mg daily treatment.

      Serum Testosterone Outcomes.jpg

      All participants reported an improvement in quality of life although younger men more so than older men. Restoring men's Testosterone levels with Clomid increases sexual function and quality of life.

      DaRos_fig_2.jpg

      Side effects

      Clomid users have reported various side effects like dizziness, vision problems, emotional swings and nausea. I have personally had mild vision issues while on Clomid but they went away when I stopped using the medicine.

      Overall Clomid is a relatively safe compound when used at reasonable dosages and in my estimation is a good option for proper Testosterone recovery and improved sexual function.

      @https://reconpeptides.com/
      heavyiron15 coupon code for 15% off
      ClomidReconSmall.png

      References
      1. Body composition measurements using DXA and other techniques in tamoxifen-treated patients.
      2. Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment.
      3. Clomiphene Citrate Effects on Testosterone/Estrogen Ratio in Male Hypogonadism
      4. Basal prolactin and the behaviour of the gonadotrophins, testosterone, androstenedione, estradiol, and the sex-hormone-binding globulin during stimulation with clomiphene in subjects with spermatogenic disorders.
      5. Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate.
      6. Clomiphene in the treatment of adolescent gynecomastia. Clinical and endocrine studies.
      7. Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study.
      8. An investigation of the visual disturbances experienced by patients on clomiphene citrate.

      ~John Connor
      heavyiron15 coupon code for 15% off at Recon Chems and Peptides
      All posts are for entertainment and may contain fiction. Consult a medical doctor before using any medications or supplements. Heavyiron does not advocate readers engage in any illegal activity.

    2. #2
      macedog24's Avatar
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      Default Re: Clomid~clomiphene citrate

      Clomid~clomiphene citrate
      Quote Originally Posted by heavyiron View Post
      Clomid~clomiphene citrate
      Clomid

      (clomiphene citrate)

      Clomiphene citrate (Clomid) is a SERM (selective estrogen receptor modulator) similar to Tamoxifen. Clomid is typically used to induce ovulation in females by blocking estrogen in selective tissue in the body. Clomid opposes the negative feedback of estrogens on the Hypothalamic Pituitary Ovarian Axis which enhances the release of LH and FSH.

      Post cycle recovery

      I consider Clomid an important recovery drug for post cycle therapy. In men, the effects of Clomid are much more pronounced than women as an increase in FSH and LH will cause a rise in natural Testosterone. After just 7 days of clomiphene citrate administration (100mg daily), mean serum total T and non-SHBG-bound levels in young men increased by a whopping 100% and 304%, respectively, while in older men these values increased by only 32% and 8%, Similar to previous observations, LH and FSH levels showed a significant elevation in response to clomiphene citrate over the response to placebo.

      Clomid is a very useful compound at the end of an AAS cycle because Testosterone quickly falls below baseline levels when steroids are withdrawn. This decline in Testosterone then allows the effects of cortisol to wreak havoc on new muscle. The user quickly goes from an anabolic to a catabolic state. Thankfully this crash can be mitigated with Clomid. Clomiphene restores normal Testosterone levels and improves sperm motility in most male patients. Clomid may also be used on cycle to block the effects of estrogen in male breast tissue therefore reducing the likelihood of gynecomastia however Nolvadex seems the preferred medicine for this purpose. Additionally, Clomid supports improved cardiovascular values.

      So how do we maximize the benefits of this recovery medicine? First we need to determine the clearance time of the AAS being used. In other words, how long will it take for the steroid to reach baseline Testosterone levels? Most steroids have a published duration in which they are no longer elevating Testosterone above natural levels but this is only an estimate as cycle duration, scar tissue and many multiple depots may extend release times of the AAS administered when using injectable compounds. Once it's determined when to employ Clomid, therapy should be about 4-6 weeks in duration. I like to start with a dose of 50-100mg's daily for 3 weeks and then reduce that dose to 50mg daily the remainder of the therapy. I recommend getting labs after Clomid therapy to determine if recovery was successful. If not, another Clomid course may be needed.

      SERM's and female fat reduction?

      Some women report a reduction in female pattern fat deposits when employing a SERM during an anabolic androgenic steroid cycle but evidence seems to be to the contrary according to a study on Nolvadex that measured body fat using a dual-energy X-ray absorptiometry (DXA). Body fat increased with Nolvadex use alone. It is likely that the lower body fat observed may be due to the steroid administration not the SERM by itself.

      Hypogonadism and low libido

      In 2012, 25mg daily Clomid administration was investigated for mitigating low male Testosterone levels and poor sexual function. Essentially the researchers studied Clomid as a treatment for hypogonadism. This treatment lasted for at least 3 months. The Clomid treatment was successful, resulting in about a two times increase of the men's Testosterone levels and improvements in sexual function. Clomid may be considered a therapeutic option for patients with symptomatic male Testosterone deficiency. The chart below provides the Testosterone outcomes by age from this 25mg daily treatment.

      Serum Testosterone Outcomes.jpg

      All participants reported an improvement in quality of life although younger men more so than older men. Restoring men's Testosterone levels with Clomid increases sexual function and quality of life.

      DaRos_fig_2.jpg

      Side effects

      Clomid users have reported various side effects like dizziness, vision problems, emotional swings and nausea. I have personally had mild vision issues while on Clomid but they went away when I stopped using the medicine.

      Overall Clomid is a relatively safe compound when used at reasonable dosages and in my estimation is a good option for proper Testosterone recovery and improved sexual function.

      BUY CLOMID NOW
      heavyiron15 coupon code for 15% off
      ClomidReconSmall.png

      References
      1. Body composition measurements using DXA and other techniques in tamoxifen-treated patients.
      2. Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment.
      3. Clomiphene Citrate Effects on Testosterone/Estrogen Ratio in Male Hypogonadism
      4. Basal prolactin and the behaviour of the gonadotrophins, testosterone, androstenedione, estradiol, and the sex-hormone-binding globulin during stimulation with clomiphene in subjects with spermatogenic disorders.
      5. Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate.
      6. Clomiphene in the treatment of adolescent gynecomastia. Clinical and endocrine studies.
      7. Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study.
      8. An investigation of the visual disturbances experienced by patients on clomiphene citrate.

      ~John Connor
      Excellent article!

      Sent from my LG-H910 using Tapatalk


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    3. #3
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      Default Re: Clomid~clomiphene citrate

      ---
      Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism.

      Shabsigh A1, Kang Y, Shabsign R, Gonzalez M, Liberson G, Fisch H, Goluboff E.
      Author information
      Abstract

      AIM:
      Symptomatic late-onset hypogonadism is associated not only with a decline in serum testosterone, but also with a rise in serum estradiol. These endocrine changes negatively affect libido, sexual function, mood, behavior, lean body mass, and bone density. Currently, the most common treatment is exogenous testosterone therapy. This treatment can be associated with skin irritation, gynecomastia, nipple tenderness, testicular atrophy, and decline in sperm counts. In this study we investigated the efficacy of clomiphene citrate in the treatment of hypogonadism with the objectives of raising endogenous serum testosterone (T) and improving the testosterone/estrogen (T/E) ratio.

      METHODS:
      Our cohort consisted of 36 Caucasian men with hypogonadism defined as serum testosterone level less than 300 ng/dL. Each patient was treated with a daily dose of 25 mg clomiphene citrate and followed prospectively. Analysis of baseline and follow-up serum levels of testosterone and estradiol levels were performed.

      RESULTS:
      The mean age was 39 years, and the mean pretreatment testosterone and estrogen levels were 247.6 +/- 39.8 ng/dL and 32.3 +/- 10.9, respectively. By the first follow-up visit (4-6 weeks), the mean testosterone level rose to 610.0 +/- 178.6 ng/dL (P < 0.00001). Moreover, the T/E ratio improved from 8.7 to 14.2 (P < 0.001). There were no side effects reported by the patients.

      CONCLUSIONS:
      Low dose clomiphene citrate is effective in elevating serum testosterone levels and improving the testosterone/estradiol ratio in men with hypogonadism. This therapy represents an alternative to testosterone therapy by stimulating the endogenous androgen production pathway.

      PMID: 16422830 DOI: 10.1111/j.1743-6109.2005.00075.x
      [Indexed for MEDLINE]
      Last edited by heavyiron; 01-06-2018 at 05:58 PM.
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    4. #4
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      Default Re: Clomid~clomiphene citrate

      ---
      The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate.

      Tenover JS1, Matsumoto AM, Plymate SR, Bremner WJ.
      Author information

      Abstract
      Serum testosterone (T) levels in men decline with age while serum LH levels, as measured by RIA, increase. To assess if the decline in serum T levels in healthy aging men is paralleled by an age-related decline in the bioavailable non-sex hormone-binding globulin (SHBG)-bound fraction of T and to determine whether there are age-related changes in LH secretion or LH control of T production, we studied 29 young (aged 22-35 yr) and 26 elderly (aged 65-84 yr) healthy men. All men had single random blood samples drawn, and 14 men in each age group underwent frequent blood sampling for 24 h, both before and after 7 days of clomiphene citrate (CC) administration. Both mean 24-h serum total T levels and non-SHBG-bound T were reduced in elderly men compared to those in young men (P less than 0.05), while estradiol and SHBG levels were similar in the 2 age groups. Serum FSH determined by RIA and LH by RIA and bioassay were higher in the elderly men compared to those in young men (P less than 0.05), but the ratios of LH bioactivity to immunoreactivity and the LH pulse frequency and amplitude were similar. After CC administration, mean serum total T and non-SHBG-bound levels in young men increased by 100% and 304%, respectively, while in older men these values increased by only 32% and 8%, respectively. However, CC-stimulated LH pulse characteristics and serum levels of estradiol, SHBG, FSH, and bioactive and immunoreactive LH were similar in the 2 groups. Thus, both at baseline and after CC stimulation, elderly men had significantly lower serum total T and non-SHBG-bound (bioavailable) T levels than did young men, despite similar or increased levels of bioactive LH and similar bioactive to immunoreactive LH ratios and LH pulse characteristics. These results suggest that major age-related changes in the hypothalamic-pituitary-testicular axis occur at the level of the testes and are manifested by decreased responsiveness to bioactive LH. Administration of CC to young and elderly men resulted in similar changes in LH pulse characteristics and LH bioactivity and immunoreactivity, suggesting preserved hypothalamic-pituitary responsiveness in the elderly.

      PMID: 3119649 DOI: 10.1210/jcem-65-6-1118
      [Indexed for MEDLINE]
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    5. #5
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      Default Re: Clomid~clomiphene citrate

      -
      Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment.

      Ribeiro RS1, Abucham J.
      Author information

      Abstract
      CONTEXT:
      Persistence of hypogonadism is common in male patients with prolactinomas under dopamine agonist (DA) treatment. Conventional therapy with testosterone causes undesirable fluctuations in serum testosterone levels and inhibition of spermatogenesis.

      OBJECTIVE:
      To evaluate the use of clomiphene as a treatment for persistent hypogonadism in males with prolactinomas.

      DESIGN:
      Open label, single-arm, prospective trial.

      PATIENTS:
      Fourteen adult hypogonadal males (testosterone <300 ng/dl and low/normal LH) with prolactinomas on DA, including seven with high prolactin (range: 29-1255 microg/l; median: 101 microg/l) despite maximal doses of DA.

      INTERVENTION:
      Clomiphene (50 mg/day orally) for 12 weeks.

      MEASURES:
      Testosterone, estradiol, LH, FSH, and prolactin were measured before and 10 days, 4, 8, and 12 weeks after clomiphene. Erectile function, sperm analysis, body composition, and metabolic profiles were evaluated before and after clomiphene.

      RESULTS:
      Ten patients (71%), five hyperprolactinemic and two normoprolactinemic, responded to clomiphene (testosterone >300 ng/dl). Testosterone levels increased from 201+/-22 to 457+/-37 ng/dl, 436+/-52, and 440+/-47 ng/dl at 4, 8, and 12 weeks respectively (0.001<P<0.01). Estradiol increased significantly and peaked at 12 weeks. LH increased from 1.7+/-0.4 to 6.2+/-2.0 IU/l, 4.5+/-0.7, and 4.6+/-0.7 IU/l at 4, 8, and 12 weeks respectively (0.001<P<0.05). FSH levels increased in a similar fashion. Prolactin levels remained unchanged. Erectile function improved (P<0.05) and sperm motility increased (P<0.05) in all six patients with asthenospermia before clomiphene.

      CONCLUSIONS:
      Clomiphene restores normal testosterone levels and improves sperm motility in most male patients with prolactinomas and persistent hypogonadism under DA therapy. Recovery of gonadal function by clomiphene is independent of prolactin levels.

      PMID: 19359408 DOI: 10.1530/EJE-09-0084
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    6. #6
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      Default Re: Clomid~clomiphene citrate

      -
      Basal prolactin and the behaviour of the gonadotrophins, testosterone, androstenedione, estradiol, and the sex-hormone-binding globulin during stimulation with clomiphene in subjects with spermatogenic disorders.

      Bolufer P, Rodriguez A, Antonio P, Bosch E, Peiró T.

      Abstract
      To clarify the significance of clomiphene test in spermatogenic disorders, it was performed on three groups of subjects: 10 with normozoospermia, 29 with oligozoospermia, and 11 with azoospermia. Two basal blood samples were drawn five days apart; prolactin, FSH, LH, estradiol, testosterone, androstenedione and sex-hormone-binding globulin were determined. 100 mg of clomiphene per day were administered for eleven consecutive days; another sample was drawn on the eleventh day and all the basal parameters, except prolactin, were determined. It may be concluded from the results: a) All the parameters studied increased significantly after clomiphene; and b) Testosterone levels obtained after clomiphene, as well as the increases in this hormone during the test and the ratio delta T/delta LH, were significantly lower in the oligozoospermic group. This finding suggests a decrease in the testicular androgenic function of this group.

      PMID: 3937739 DOI: 10.1055/s-0029-1210487
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    7. #7
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      Default Re: Clomid~clomiphene citrate

      Let's hear it for the boyz...WOOT! WOOT!
      Kind, creative soul, with no mean bones

    8. #8
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      Default Re: Clomid~clomiphene citrate

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      This is interesting. Lets hear from some clomid users please. I havent used it for years, but maybe I should consider trying it. Please share your clomid experiences. I

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