T3 info by Paneria

got this off of elite. he has other aliases...

Taken from the site: https://www.rxmed.com/monographs/cytomel.html

Liothyronine is readily available to body tissues. Following oral administration, about 95% of the dose is absorbed from the gastrointestinal tract in 4 hours. The onset of activity of liothyronine is rapid, occurring within a few hours. Maximum pharmacologic response occurs within 2 or 3 days, providing early clinical response. The biological half-life is about 2.5 days. The drug has a rapid cut off of activity, which permits quick dosage adjustment and facilitates control of the effects of overdosage, should they occur. Liothyronine is metabolized to deiodinated and conjugated metabolites which are excreted in the urine.

It is not necessary to divide daily maintenance doses. Although liothyronine has a rapid cut-off, its metabolic effects persist for a few days following discontinuance

Some more infro taken from the site:

https://thyroid.about.com/health/thy...yroid-drugs.htm

1. Always check the prescription against what you receive. Don't allow generic substitutions.
2. Most doctors feel that taking thyroid hormone on an empty stomach allows for maximum absorption.
3. Many practitioners advise that you allow at least one hour before eating, because it allows for maximum absorption.
4. Be consistent about a high-fiber diet. If you start or stop eating high-fiber, get your thyroid rechecked, because it may change your absorption.
5. Many experts recommend you take vitamins or supplements with iron at least two to three hours apart from thyroid hormone. Iron can interfere with thyroid hormone absorption if taken too close together.
6. Be careful about taking calcium and calcium-fortified orange juice at the same time as thyroid hormone. Allow at least 2-3 hours apart, so absorption is not affected.
7. Don't take antacids within two hours of thyroid hormone. Allow at least 2-3 hours apart, so absorption is not affected.
*8. Watch for interactions with antidepressants & thyroid hormone. Zoloft, Paxil and Prozac can make thyroid meds more or less effective. Talk to your doctor.
9. Don't stop taking thyroid hormone when you're pregnant or breastfeeding. It's necessary for you and your baby's health. Talk to your doctor about adjusting to the right dosage.

* see my thread on Cytochrome P450 pathways by LewdTenant