If they are just playing rough occasionally, they should be fine. If the fights escalate to where you can tell they are serious, and you should be able to tell. Then they may need to be separated. My males would go at the m in nute they seen each other with bad intentions, but my female would whoop both of them rough housing. Neither of my males ever got serious with the female. Pitbull puppies like to rough house, if you had a litter it would be non stop squabs in the pen around 8-12 weeks. Your bigger dogs will put the pup in her place if she gets to rough, ita about dominance and play right now. But that could change as they get older and she has her first heat.